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Impacts of curcumin on the healing procedure of eye cataracts in a rabbit model | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 22 آبان 1403 اصل مقاله (668.19 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.8148 | ||
| نویسندگان | ||
| Babak Olia1؛ Farrokhreza Kabir* 1؛ Siamak Mashhadi Rafiei2 | ||
| 1Department of Radiology, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Small Animal Internal Medicine, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| چکیده | ||
| Curcumin is a natural antioxidant agent derived from turmeric. The present survey assessed the anti-cataract effect of curcumin on experimentally induced cataracts in rabbit models. Twenty-four healthy rabbits were selected, numbered, and kept individually in separate cages for 2 weeks with routine feeding. Clinical examinations were done to assess the rabbit’s eye health. Up to cataract formation, all rabbits received 0.1% sodium selenite (1 mg kg-1 body weight subcutaneously). Then, rabbits were classified into four groups: control group I (without any oral treatment), control II (with oral normal saline), treatment I (oral consumption of commercial curcumin), and treatment II (oral consumption of vitamin E). Curcumin, vitamin E, and normal saline were fed to rabbits 3 times a day for 20 days at a rate of 15 mg kg-1 body weight each time. Then, during ultrasound, the diameters of the anterior capsule of the lens, the posterior capsule of the lens, and the anterior-posterior of the lens were evaluated. Examination with slit lamp biomicroscopy was also done once every 3 days. Injection of 1 mg kg-1 of body weight every 72 h three times caused rabbits to survive for more than a month, and the cataract was created. An increase in the thickness of the lens anterior and posterior capsules could be seen and measured from the 4th day, and this increase continued until the 12th day and did not change until the last day of the study. Sodium selenite caused an elevation in the diameters of the lens anterior, posterior, and anterior-posterior capsules. On the 20th day of the experiment, the lowest diameter of the anterior, posterior, and anterior-posterior capsules was obtained for rabbits of treatment I (Curcumin; 0.063 ± 0.002, 0.065 ± 0.002, and 0.598 ± 0.02 cm, respectively). Statistically significant differences were obtained for the diameter of the lens capsules between treatment I and control and treatment II (p < 0.05). The administration of oral curcumin (1 mg kg-1 body weight 3 times a day for 20 days) significantly inhibited eye cataracts induced by sodium selenite in rabbit models. Rendering the edible route of curcumin and its beneficial effects, as well as synthesizing edible drugs based on curcumin for treating eye cataracts, has been recommended. | ||
| کلیدواژه‌ها | ||
| Curcumin؛ Vitamin E؛ Cataract؛ Rabbit؛ Ultrasonography | ||
| مراجع | ||
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Al-Musawi, AT 2022, Inhibitory activity of curcumin extract against some bacteria causing food poisoning isolated from some ready-to-eat meals. Caspian Journal of Environmental Sciences, 20: 1047-1052.
Awasthi, S, Srivatava, SK, Piper, JT, Singhal, SS, Chaubey, M & Awasthi, YC 1996, Curcumin protects against 4-hydroxy-2-trans-nonenal-induced cataract formation in rat lenses. The American Journal of Clinical Nutrition, 64: 761–766.
Awasthi, S, Srivatava, SK, Piper, JT, Singhal, SS, Chaubey, M & Awasthi, YC 1996, Curcumin protects against 4-hydroxy-2-trans-nonenal–induced cataract formation in rat lenses. The American Journal of Clinical Nutrition, 64: 761-6.
Badaro, E, Cassini, P, Andrade, GC, Rodrigues, GB, Novais, EA & Rodrigues, EB 2022, Preliminary study of rabbits as an animal model of mammalian eye transplantation and literature review. Revista Brasileira de Oftalmologia, 81: e0026.
Baha’a, A & Alzubaidy, AA 2014, Role of Topically-Applied Zinc Sulfate in Prevention of Sodium Selenite-Induced Cataract in Rabbits. International Journal of Advanced Research, 2: 1014-22.
Del Amo, EM & Urtti, A 2015, Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data. Experimental Eye Research, 137: 111-24.
Fichtner, JE, Patnaik, J, Christopher, KL & Petrash, JM 2021, Cataract inhibitors: Present needs and future challenges. Chemico-Biological Interactions, 349: 109679.
Grama, CN, Suryanarayana, P, Patil, MA, Raghu, G, Balakrishna, N, Ravi Kumar, MNV & Reddy, GB 2013, Efficacy of biodegradable curcumin nanoparticles in delaying cataract in diabetic rat model. PLoS ONE, 8: e78217
Hewlings, SJ & Kalman, DS 2017, Curcumin: A review of its effects on human health. Foods, 6: 92.
Kulbay, M, Wu, KY, Nirwal, GK, Bélanger, P & Tran, SD 2024, Oxidative Stress and Cataract Formation: Evaluating the Efficacy of Antioxidant Therapies. Biomolecules, 14: 1055.
Lam, D, Rao, SK, Ratra, V, Liu, Y, Mitchell, P, King, J, Tassignon, MJ, Jonas, J, Pang, CP & Chang, DF 2015, Cataract. Nature Reviews Disease Primers, 1: 1-5.
López-Malo, D, Villarón-Casares, CA, Alarcón-Jiménez, J, Miranda, M, Díaz-Llopis, M, Romero, FJ & Villar, VM 2020, Curcumin as a therapeutic option in retinal diseases. Antioxidants, 9: 48.
Manikandan, R, Thiagarajan, R, Beulaja, S, Chindhu, S, Mariammal, K, Sudhandiran, G & Arumugam, M 2009, Anti-cataractogenic effect of curcumin and aminoguanidine against selenium-induced oxidative stress in the eye lens of Wistar rat pups: an in vitro study using isolated lens. Chemico-Biological Interactions, 181: 202–209.
Manikandan, R, Thiagarajan, R, Beulaja, S, Sudhandiran, G & Arumugam, M 2010, Curcumin prevents free radical-mediated cataractogenesis through modulations in lens calcium. Free Radical Biology and Medicine, 48: 483–492.
Mapara, M, Thomas, BS & Bhat, KM 2012, Rabbit as an animal model for experimental research. Dental Research Journal, 9: 111.
Meacock, WR, Spalton, DJ, Boyce, J & Marshall, J 2003, The effect of posterior capsule opacification on visual function. Investigative Ophthalmology & Visual Science, 44: 4665-9.
Nunes, YC, Mendes, NM, Pereira de Lima, E, Chehadi, AC, Lamas, CB, Haber, JF, dos Santos Bueno, M, Araújo, AC, Catharin, VC, Detregiachi, CR & Laurindo, LF 2024, Curcumin: A golden approach to healthy aging: A systematic review of the evidence. Nutrients, 16: 2721.
Okhovatfard, M & Rezazadeh, H 2023, Effect of Curcuma longa and its derivatives, curcumin and curcuminoids on treatment of oral lichen planus: A systematic review of clinical evidence. Caspian Journal of Environmental Sciences, 1-12.
Padmaja, S & Raju, TN 2004, Antioxidant effect of curcumin in selenium induced cataract of Wistar rats. Indian Journal of Experimental Biology, 42: 601–603.
Radha, A, Rukhmini, SD, Vilasini, S, Sakunthala, PR, Sreedharan, B, Velayudhan, MP & Abraham, A 2012, Bioactive derivatives of curcumin attenuate cataract formation in vitro. Chemical Biology and Drug Design, 80: 887–892.
Rathore, S, Mukim, M, Sharma, P, Devi, S, Nagar, JC & Khalid, M 2020, Curcumin: A review for health benefits. International Journal of Research and Review, 7: 273-90.
Shahreza, MS 2022, Ready to eat food samples as reservoirs of Shiga toxigenic Escherichia Coli. Journal of Pharmaceutical Negative Results, 31: 9761-6.
Shahreza, MS, Dehkordi, NG, Nassar, MF & Al-Saedi, RM 2022, Virulence characters and oligotyping of Pseudomonas aeruginosa isolated from meat and assessment of the antimicrobial effects of Zataria multiflora against isolates. Academic Journal of Health Sciences, 37: 11-16.
Singh, S, Sharma, S & Basu, S 2021, Rabbit models of dry eye disease: Current understanding and unmet needs for translational research. Experimental Eye Research, 206: 108538.
Suryanarayana, P, Saraswat, M, Mrudula, T, Krishna, TP, Krishnaswamy K & Reddy GB 2005, Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Investigative Ophthalmology & Visual Science, 46: 2092–2099.
Wu, S, Tong, N, Pan, L, Jiang, X, Li, Y, Guo, M & Li, H 2018, Retrospective analyses of potential risk factors for posterior capsule opacification after cataract surgery. Journal of Ophthalmology, 1: 9089285.
Zernii, EY, Baksheeva, VE, Iomdina, EN, Averina, OA, Permyakov, SE, Philippov, PP, Zamyatnin, AA & Senin, II 2016, Rabbit models of ocular diseases: new relevance for classical approaches. CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders), 15: 267-91.
Zhuang, GB, Li, X, Wu, SN, Zhang, SQ, Zhang, ZJ & Dong, N 2024, The impact of vitamin E, vitamin B6, and niacin intake on cataract incidence based on NHANES 2005-2008 data. Frontiers in Nutrition, 11: 1406147. | ||
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