پیوندهای مفید
آمار
| تعداد نشریات | 31 |
| تعداد شماره‌ها | 757 |
| تعداد مقالات | 7,162 |
| تعداد مشاهده مقاله | 10,347,627 |
| تعداد دریافت فایل اصل مقاله | 6,937,292 |
Ameliorative effects of Glycyrrhiza glabra L. (licorice) on animal and human pulmonary fibrosis: A review of current knowledge | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 15 آبان 1403 اصل مقاله (977.65 K) | ||
| نوع مقاله: Reviewers | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.8133 | ||
| نویسندگان | ||
| Ali H Amin1؛ Ujwal R. Shirode2؛ A.G. Sherov3؛ Mabrouk A. Abo-Zaid4؛ Ahmed H Ismail5؛ Shouket A. Tilwani* 6 | ||
| 1Zoology Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt. | ||
| 2Department of Electronics and Telecommunication, Pimpri Chinchwad College of Engineering, Pune, Maharashtra, India | ||
| 3Tashkent Institute of Irrigation and Agricultural Mechanization Engineers National Research University, Uzbekistan; Western Caspian University, Scientific researcher, Baku, Azerbaijan. | ||
| 4Department of Biology, College of Science, Jazan University, P.O. Box 114, Jazan 45142, Kingdom of Saudi Arabia | ||
| 5Department of Biology, College of Science, Jazan University, P.O. Box 114, Jazan 45142, Kingdom of Saudi Arabia. | ||
| 6College of Science and Humanities, Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia. | ||
| چکیده | ||
| Airway inflammation plays an important role in the pathogenesis of acute respiratory distress syndrome (ARDS), asthma, and chronic obstructive pulmonary disease (COPD), and anti-inflammatory therapy effectively improves the symptoms of these diseases. There are more than 30 species of the genus Glycyrrhiza, which are widely distributed throughout the world. Licorice root extracts have beneficial effects in the treatment of throat infections, tuberculosis, respiratory diseases, liver, antibacterial, anti-inflammatory, and immunodeficiency. Therefore, the focus of this article is a review of the molecular mechanism of licorice extracts and its four flavonoids (isolycoirithigenin, licoirithigenin, lycalocone and glabidine) and their therapeutic effects on respiratory distress syndrome and fibrosis caused by this disease. Licorice with its combination of flavonoid, triterpenoid, saponin, and isoflavones plays an important role in reducing inflammation, strengthening the immune system and antioxidant properties. Licorice can be a natural alternative to current treatment to eliminate new emerging pathogens such as viral diseases with side effects. Based on this systematic review article, it is suggested that licorice effectively reduces lung inflammation caused by viral pathogens by inhibiting the infiltration of inflammatory cells and the release of inflammatory mediators, which subsequently results in neutrophil recruitment in the lung and neutrophil-mediated oxidative damage, edema and Reduces congestion. Therefore, products that target transforming growth factor (TGF)-β1 signaling proteins, Smads, and phosphorylated Smads (p-Smads), with the ability of epithelial cells to adopt mesenchymal phenotypes, may be useful in developing therapies. New pulmonary fibrosis should be followed by respiratory distress syndrome. | ||
| کلیدواژه‌ها | ||
| Licorice؛ Acute respiratory distress syndrome؛ Animal؛ Pulmonary fibrosis؛ Pathogen | ||
| مراجع | ||
|
Ali, EM 2013, ‘Phytochemical composition, antifungal, antiaflatoxigenic, antioxidant, and anticancer activities of Glycyrrhiza glabra L. and Matricaria chamomilla L. essential oils. Journal of Medicinal Plants Research, 7: 2197–2207.
Almatroodi, SA, Alsahli, MA, Almatroudi, A, Verma, AK, Aloliqi, A, Allemailem, KS, Khan, AA & Rahmani, AH 2021, Potential therapeutic targets of quercetin, a plant flavonol, and its role in the therapy of various types of cancer through the modulation of various cell signaling pathways. Molecules (Basel, Switzerland), 26 (5).
Ammar, NM, El-Hawary, SSE-D, El-Anssary, AA, Othman, N, Galal, M & El-Desoky, AH 2012, Phytochemical and clinical studies of the bioactive extract of Glycyrrhiza glabra L. Family Leguminosae. International Journal of Phytomedicine, 4: 429.
Bisht, D, Rashid, M, Arya, RKK, Kumar, D, Chaudhary, SK, Rana, VS & Sethiya, NK 2022, Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight. Phytomedicine Plus, 2: 100206.
Bormann, T, Maus, R, Stolper, J, Tort Tarrés, M, Brandenberger, C, Wedekind, D, Jonigk, D, Welte, T, Gauldie, J & Kolb, M 2022, ‘Role of matrix metalloprotease-2 and MMP-9 in experimental lung fibrosis in mice. Respiratory Research, 23: 180.
Buder, F, Selejan, S-R, Hohl, M, Kindermann, M, Herr, C, Lepper, PM, Bals, R, Salzberger, B, Mahfoud, F & Böhm, M 2022, ‘Glycyrrhizin through liquorice intake modulates ACE2 and HMGB1 levels-A pilot study in healthy individuals with implications for COVID-19 and ARDS. PloS One, 17(10): e0275181.
Chanda, D, Otoupalova, E, Smith, SR, Volckaert, T, De Langhe, SP & Thannickal, VJ 2019, Developmental pathways in the pathogenesis of lung fibrosis. Molecular Aspects of Medicine, 65: 56–69.
Chen, H, Muhammad, I, Zhang, Y, Ren, Y, Zhang, R, Huang, X, Diao, L, Liu, H, Li, X, Sun, X, Abbas, G & Li, G 2019, ‘Antiviral activity against infectious bronchitis virus and bioactive components of Hypericum perforatum L. Frontiers in Pharmacology, 10: 1272.
Cinatl, J, Morgenstern, B, Bauer, G, Chandra, P, Rabenau, H & Doerr, H 2003, ‘Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. The Lancet, 361: 2045–2046.
Crouch, E 1990, ‘Pathobiology of pulmonary fibrosis. American Journal of Physiology-Lung Cellular and Molecular Physiology, 259:159–184.
Dang, L, Jin, Y, Yuan, Y, Shao, R & Wang, Y 2024, The King of Chinese Medicine- Glycyrrhiza glabra L. (Licorice): All-round Inquiry in its chemical composition, pharmacodynamics, traditional and medicinal value. Acupuncture and Herbal Medicine, LWW, pp. 1097.
Dastagir, G & Rizvi, MA 2016, ‘Glycyrrhiza glabra L. (Liquorice). Pakistan Journal of Pharmaceutical Sciences, vol. 29, no. 5.
Ding, H, Deng, W, Ding, L, Ye, X, Yin, S & Huang, W 2020, Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in nonhospitalized COVID‐19 patients. Journal of Medical Virology, 92: 2200–2204.
Dogan, MF, Parlar, A, Cam, SA, Tosun, EM, Uysal, F & Arslan, SO 2020, ‘Glabridin attenuates airway inflammation and hyperresponsiveness in a mice model of ovalbumin-induced asthma. Pulmonary Pharmacology & Therapeutics, 63: 101936.
Eghlima, G, Kheiry, A, Sanikhani, M, Hadian, J, Aelaei, M & Ebrahimi, SN 2020, Glycyrrhiza glabra L., International Journal of Horticultural Science and Technology, 7(4).
Farhadi, L, Mohammadi-Motlagh, H-R, Seyfi, P & Mostafaie, A 2014, ‘Low concentrations of flavonoid - rich fraction of shallot extract induce delayed - type hypersensitivity and TH1 cytokine IFN-gamma expression in Balb/C mice. International Journal of Molecular and Cellular Medicine, vol. 3, no. 1, viewed <http://ijmcmed.org/ article-1-127-en.html>.
Franceschelli, S, Pesce, M, Vinciguerra, I, Ferrone, A, Riccioni, G, Patruno, A, Grilli, A, Felaco, M & Speranza, L 2011, ‘Licocalchone-C extracted from Glycyrrhiza glabra L. inhibits lipopolysaccharide-interferon-γ inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. Molecules (Basel, Switzerland), 16: 5720–5734.
Gad El-Hak, HN, Mohamed, OE & Nabil, ZI 2022, Evaluating the protective role of deglycyrrhizinated licorice root supplement on bleomycin induced pulmonary oxidative damage. Toxicology Mechanisms and Methods, 32: 180–193.
Gao, Y, Lv, X, Yang, H, Peng, L & Ci, X 2020, Isoliquiritigenin exerts antioxidative and anti-inflammatory effects via activating the KEAP-1/Nrf2 pathway and inhibiting the NF-κB and NLRP3 pathways in carrageenan-induced pleurisy. Food & Function, 11: 2522–2534.
Glass, DS, Grossfeld, D, Renna, HA, Agarwala, P, Spiegler, P, DeLeon, J & Reiss, AB 2022, Idiopathic pulmonary fibrosis: Current and future treatment. The Clinical Respiratory Journal, 16: 84–96.
Glasser, SW, Hagood, JS, Wong, S, Taype, CA, Madala, SK & Hardie, WD 2016, Mechanisms of lung fibrosis resolution. The American Journal of Pathology, 186: 1066–1077.
Hayashi, H, Hiraoka, N, Ikeshiro, Y & Yamamoto, H 1996, Organ specific localization of flavonoids in Glycyrrhiza glabra L., Plant Science, 116: 233–238.
Hayashi, H, Yasuma, M, Hiraoka, N, Ikeshiro, Y, Yamamoto, H, Yeşilada, E, Sezik, E, Honda, G & Tabata, M 1996, Flavonoid variation in the leaves of Glycyrrhiza glabra. Phytochemistry, Elsevier, 42: 701–704.
Hoever, G, Baltina, Lidia, Michaelis, M, Kondratenko, R, Baltina, Lia, Tolstikov, GA, Doerr, HW & Cinatl, J 2005, Antiviral activity of glycyrrhizic acid derivatives against SARS−coronavirus. Journal of Medicinal Chemistry, vol. 48, no. 4, ACS Publications, pp. 1256–1259.
Hosseini, SA, Zahedipour, F, Sathyapalan, T, Jamialahmadi, T & Sahebkar, A 2021, Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals. BioFactors, 47: 250–269.
James, A, Gunasekaran, N, Krishnan, R, Arunachalam, P & Mahalingam, R 2022, ‘Anti-fibrotic activity of licorice extract in comparison with colchicine on areca nut-induced fibroblasts: An in vitro study. Journal of Oral and Maxillofacial Pathology: JOMFP, 26: 173–178.
Jiang, R-H, Xu, J-J, Zhu, D-C, Li, J-F, Zhang, C-X, Lin, N & Gao, W-Y 2020, Glycyrrhizin inhibits osteoarthritis development through suppressing the PI3K/AKT/NF-κB signaling pathway in vivo and in vitro. Food & Function, vol. 11, no. 3, Royal Society of Chemistry, pp. 2126–2136.
Kang, JS, Yoon, YD, Cho, IJ, Han, MH, Lee, CW, Park, S-K & Kim, HM 2005, Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. Journal of Pharmacology and Experimental Therapeutics, 312: 1187–1194.
Kaur, R, Kaur, H & Dhindsa, AS 2013, Glycyrrhiza glabra: A phytopharmacological review. International Journal of Pharmaceutical Sciences and Research, 4: 2470.
Khalaf, I, Vlase, L, Lazăr, D, Corciovă, A, Ivanescu, B & Lazăr, MI 2010, HPLC-MS study of phytoestrogens from Glycyrrhiza glabra’, Farmacia, 58: 89–94.
Kim, S-H, Hong, J-H, Yang, W-K, Geum, J-H, Kim, H-R, Choi, S-Y, Kang, Y-M, An, H-J & Lee, Y-C 2020, Herbal combinational medication of Glycyrrhiza glabra, Agastache rugosa containing glycyrrhizic acid, tilianin inhibits neutrophilic lung inflammation by affecting CXCL2, interleukin-17/STAT3 signal pathways in a murine model of COPD. Nutrients, 12: 926.
Kinoshita, T, Tamura, Y & Mizutani, K 2005, The isolation and structure elucidation of minor isoflavonoids from licorice of Glycyrrhiza glabra L. origin, Chemical and Pharmaceutical Bulletin, 53: 847–849.
Koli, K, Myllärniemi, M, Vuorinen, K, Salmenkivi, K, Ryynänen, MJ, Kinnula, VL & Keski-Oja, J 2006, Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. The American Journal of Pathology, 169: 61–71.
Kovalenko, PG, Antonjuk, VP & Maliuta, SS 2004, Secondary metabolites synthesis in transformed cells of Glycyrrhiza glabra L. and Potentilla alba L. as producents of radioprotective compounds’, Ukrainica Bioorganica Acta, 1: 13–22.
Li, L-C & Kan, L-D 2017, ‘Traditional Chinese medicine for pulmonary fibrosis therapy: Progress and future prospects’, Journal of Ethnopharmacology, 198: 45–63.
Li, W, Asada, Y & Yoshikawa, T 2000, Flavonoid constituents from Glycyrrhiza glabra L. hairy root cultures. Phytochemistry, 55: 447–456.
Loni, F, Maghsodi, H & Shiri, S 2017, The effect of Glycirrhiza glabra on osteoarthritis: Suppression of TNF-a, IL-1b, Cox-2, iNOS gene expression and prostaglandin E2 and nitric oxide production in chondrocytes and monocyte/macrophages. Health Biotechnology and Biopharma, 1: 70–82.
Manfredi, KP, Vallurupalli, V, Demidova, M, Kindscher, K & Pannell, LK 2001, ‘Isolation of an anti-HIV diprenylated bibenzyl from Glycyrrhiza lepidota. Phytochemistry, 58: 153–157.
Manoury, B, Nénan, S, Guénon, I, Lagente, V & Boichot, E 2007, Influence of early neutrophil depletion on MMPs/TIMP-1 balance in bleomycin-induced lung fibrosis. International Immunopharmacology, 7: 900–911.
Matute-Bello, G, Wurfel, MM, Lee, JS, Park, DR, Frevert, CW, Madtes, DK, Shapiro, SD & Martin, TR 2007, Essential role of MMP-12 in Fas-induced lung fibrosis’, American Journal of Respiratory Cell and Molecular Biology, 37: 210–221.
Mishra, NK, Bstia, S, Mishra, G, Chowdary, KA & Patra, S 2011, Anti-arthritic activity of Glycyrrhiza glabra, Boswellia serrata and their synergistic activity in combined formulation studied in freund’s adjuvant induced arthritic rats. Journal of Pharmaceutical Education and Research, 2: 92.
Nagao, Y, Sata, M, Suzuki, H, Tanikawa, K, Itoh, K & Kameyama, T 1996, Effectiveness of glycyrrhizin for oral lichen planus in patients with chronic HCV infection’, Journal of Gastroenterology, 31: 691–695.
Najafipour, R, Mohammadi, D, Momeni, M & Moghbelinejad, S 2022, ‘ACE-2 Expression and Methylation Pattern in Bronchoalveolar Lavage Fluid and Bloods of Iranian ARDS Covid-19 Patients’, International Journal of Molecular and Cellular Medicine, 11 (1), viewed <http://ijmcmed.org/article-1-1867-en.html>.
Nassan, MA, Soliman, MM, Aldhahrani, A, Althobaiti, F & Alkhedaide, AQ 2021, Ameliorative impacts of Glycyrrhiza glabra L. root extract against nephrotoxicity induced by gentamicin in mice. Food Science & Nutrition, 9: 3405–3413.
Niu, W, Wu, F, Cui, H, Cao, W, Chao, Y, Wu, Z, Fan, M & Liang, C 2020, Network pharmacology analysis to identify phytochemicals in traditional Chinese medicines that may regulate ACE2 for the treatment of COVID‐19. Evidence‐Based Complementary and Alternative Medicine, 1: 7493281.
Nomura, T, Fukai, T & Akiyama, T 2002, Chemistry of phenolic compounds of licorice (Glycyrrhiza species) and their estrogenic and cytotoxic activities’, Pure and Applied Chemistry, 74: 1199–1206.
Pastorino, G, Cornara, L, Soares, S, Rodrigues, F & Oliveira, MBPP 2018, Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phytotherapy Research, 32: 2323–2339.
Peirzadeh, S, Fakhari, S, Jalili, A, Mirzai, S, Ghaderi, B & Haghshenas, V 2014, Glycyrrhetinic acid induces apoptosis in leukemic HL60 Cells through upregulating of CD95/ CD178. International Journal of Molecular and Cellular Medicine, 3 (4), viewed <http://ijmcmed.org/article-1-172-en.html>.
Peng, F, Du, Q, Peng, C, Wang, N, Tang, H, Xie, X, Shen, J & Chen, J 2015, A review: The pharmacology of isoliquiritigenin. Phytotherapy Research, 29: 969–977.
Qiao, X, Liu, C-F, Ji, S, Lin, X-H, Guo, D-A & Ye, M 2014, Simultaneous determination of five minor coumarins and flavonoids in Glycyrrhiza uralensis by solid-phase extraction and high-performance liquid chromatography/ electrospray ionization tandem mass spectrometry. Planta Medica, 80: 237–242.
Robin, Kaur, P, Kaur, J, Kaur, K & Miglani, S 2023, Plant-derived immunomodulators targeting COVID-19 (SARS-CoV-2): Preclinical evaluation and clinical trials. Bioprospecting of Tropical Medicinal Plants, Springer, pp. 1515–1531.
Safdarpour, S, Eftekhari, Z, Eidi, A & Doroud, D 2022, Encapsulated saponin by ferritin nanoparticles attenuates the murine pneumococcal pneumonia. Microbial Pathogenesis, 172: 105731.
Selman, M, Ruiz, V, Cabrera, S, Segura, L, Ramírez, R, Barrios, R & Pardo, A 2000, TIMP-1,-2,-3, and-4 in idiopathic pulmonary fibrosis. A prevailing nondegradative lung microenvironment? American Journal of Physiology-Lung Cellular and Molecular Physiology, 279: 562–574.
Shehu, IA & Datta, A 2022, Therapeutic profile of Glycyrrhiza glabra: A ray of hope in treating COVID-19’, Malaysian Journal of Pharmaceutical Sciences, 20: 147–167.
Sinha, SK, Prasad, SK, Islam, MA, Gurav, SS, Patil, RB, AlFaris, NA, Aldayel, TS, AlKehayez, NM, Wabaidur, SM & Shakya, A 2021, Identification of bioactive compounds from Glycyrrhiza glabra L. as possible inhibitor of SARS-CoV-2 spike glycoprotein and non-structural protein-15: A pharmacoinformatics study. Journal of Biomolecular Structure and Dynamics, 39: 4686–4700.
Sun, H-X & Pan, H-J 2006, ‘Immunological adjuvant effect of Glycyrrhiza uralensis saponins on the immune responses to ovalbumin in mice’, Vaccine, 24: 1914–1920.
Sun, L, Yang, Z, Zhang, J & Wang, J 2021, Isoliquiritigenin attenuates acute renal injury through suppressing oxidative stress, fibrosis and JAK2/STAT3 pathway in streptozotocin-induced diabetic rats’, Bioengineered, 12: 11188–11200.
Tahoori, F, Ahmad, M, Nejadsattari, T, Ofoghi, H & Iranbakhsh, A 2019, Qualitative and quantitative study of quercetin and glycyrrhizin in in vitro culture of Liquorice (Glycyrrhiza glabra L.) and elicitation with AgNO3. Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 47: 143–151.
Tang, Y, Wang, C, Wang, Y, Zhang, J, Wang, F, Li, L, Meng, X, Li, G, Li, Y & Wang, L 2018, Isoliquiritigenin attenuates LPS-induced AKI by suppression of inflammation involving NF-κB pathway’, American Journal of Translational Research, 10: 4141.
Traboulsi, H, Cloutier, A, Boyapelly, K, Bonin, M-A, Marsault, É, Cantin, AM & Richter, M V 2015, The flavonoid isoliquiritigenin reduces lung inflammation and mouse morbidity during influenza virus infection. Antimicrobial Agents and Chemotherapy, 59: 6317–6327.
Vashist, H & Sharma, D 2013, Pharmacognostical aspects of Glycyrrhiza glabra. Asian Journal of Pharmaceutical and Clinical Research, 6: 55–59.
Visavadiya, NP, Soni, B & Dalwadi, N 2009, ‘Evaluation of antioxidant and anti-atherogenic properties of Glycyrrhiza glabra L. root using in vitro models. International journal of food sciences and nutrition, 60: 135–149.
Wahab, S, Ahmad, I, Irfan, S, Siddiqua, A, Usmani, S & Ahmad, MP 2022, ‘Pharmacological efficacy and safety of Glycyrrhiza glabra L. in the treatment of respiratory tract infections. Mini Reviews in Medicinal Chemistry, 22: 1476–1494.
Wang, J-F, Liu, S-S, Song, Z-Q, Xu, T-C, Liu, C-S, Hou, Y-G, Huang, R & Wu, S-H 2020, ‘Naturally occurring flavonoids and isoflavonoids and their microbial transformation: A review. Molecules, 25: 5112.
Williamson, EM 2003, Potter’s cyclopedia of herbal medicine. CW Daniel, Saffron Walden, pp. 269–271.
Yang, N, Patil, S, Zhuge, J, Wen, M, Bolleddula, J, Doddaga, S, Goldfarb, J, Sampson, HA & Li, X 2013, Glycyrrhiza uralensis flavonoids present in anti‐asthma formula, ASHMITM, inhibit memory Th2 responses in vitro and in vivo’, Phytotherapy Research, 27: 1381–1391.
Yi, Y, Li, J, Lai, X, Zhang, M, Kuang, Y, Bao, Y-O, Yu, R, Hong, W, Muturi, E & Xue, H 2022, ‘Natural triterpenoids from licorice potently inhibit SARS-CoV-2 infection’, Journal of Advanced Research, 36: 201–210.
Yu, D, Liu, X, Zhang, G, Ming, Z & Wang, T 2018, Isoliquiritigenin inhibits cigarette smoke-induced COPD by attenuating inflammation and oxidative stress via the regulation of the Nrf2 and NF-κB signaling pathways. Frontiers in Pharmacology, 9: 1001.
Yu, X-Q, Xue, CC, Zhou, Z-W, Li, C-G, Du, Y-M, Liang, J & Zhou, S-F 2008, In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra L. (licorice). Life Sciences, 82: 68–78.
Zhang, Q & Ye, M 2009, ‘Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)’, Journal of Chromatography A, 1216:1954–1969. | ||
|
آمار تعداد مشاهده مقاله: 277 تعداد دریافت فایل اصل مقاله: 149 |
||