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آشکارسازی پاسخ به عفونت آنفلوانزای H5N1: تجزیه و تحلیل مقایسه ای شبکه های بیان ژن و مسیرهای غنی شده عملکردی در جوجه ها و اردک ها | ||
تحقیقات تولیدات دامی | ||
دوره 12، شماره 4، اسفند 1402، صفحه 1-22 اصل مقاله (1.9 M) | ||
نوع مقاله: مقاله پژوهشی | ||
شناسه دیجیتال (DOI): 10.22124/ar.2023.24839.1773 | ||
نویسندگان | ||
ساره گل پسند1؛ شاهرخ قوتی* 2؛ زهرا پزشکیان3 | ||
1دانشجوی کارشناسی ارشد، گروه علوم دامی، دانشکده علوم کشاورزی، دانشگاه گیلان | ||
2استادیار، گروه علوم دامی، دانشکده علوم کشاورزی، دانشگاه گیلان | ||
3دانش آموخته دکتری، گروه علوم دامی، دانشکده علوم کشاورزی، دانشگاه گیلان | ||
چکیده | ||
درک ساز و کارهای مولکولی پاسخ میزبان به عفونت H5N1 برای گسترش اقدامات کنترل موثر و کاهش خطر یک بیماری همهگیر بالقوه بسیار مهم است. هدف مطالعه حاضر، تجزیه دادههای ریزآرایه آنفلوانزای فوق حاد پرندگان H5N1 جهت مقایسه شبکه ژنی در جوجهها و اردکها بود. مجموعه داده ریزآرایه GSE33389 مشتمل بر نمونه شاهد و زیر چالش H5N1 بافت ریه جوجه و اردک با بسته GEOquery نرمافزار R دانلود شد. ژنهای با بیان متفاوت با استفاده از بسته limma در نرمافزار R شناسایی شدند و سپس، ترسیم شبکههای ژنی با نرم افزار Cytoscape انجام شد. ژنهای اصلی با تعاملات زیاد با افزونه Cytohubba شناسایی شدند و در نهایت، ماژولهای اثرگذار با افزونه MCODE شناسایی شدند. تعداد 2062 و 565 ژن با بیان متفاوت بین بافت سالم و زیر چالش به ترتیب در جوجهها و اردکها شناسایی شدند (05/0P< و >2 |logFC|). نتایج تجزیه شبکه با استفاده از افزونه Cytohubba، ژنهایBUB1 ، NDC80، CDC20 را بهعنوان ژنهای هاب در جوجه و همچنین ژنهای کلیدی COL6A3، COL3A1 و PLOD2 را در اردک شناسایی نمود (05/0P<). مقایسه هستیشناسی ژنهای متفاوت بیان شده در جوجه و اردک نشان داد که بیشتر آنها در جوجهها در پاسخ ایمنی ذاتی و مقاومتهای التهابی میزبان نقش دارند، ولی در اردک بیشتر در سوخت و ساز چربی و تولید انرژی برای تامین نیازمندی مقاومت میزبان در برابر بیماری نقش ایفا میکنند. یافتههای این مطالعه ضمن افزایش آگاهی نسبت به چگونگی پاسخ میزبان به عفونت آنفلوانزای H5N1، ممکن است دستاوردهایی برای توسعه درمان هدفمند و راهبردهای نظارتی برای مبارزه موثر با شیوع H5N1 داشته باشد. | ||
کلیدواژهها | ||
آنفلوانزای فوق حاد پرندگان H5N1؛ بیوانفورماتیک؛ ریزآرایه؛ شبکه تعامل ژن؛ هستی شناسی ژن | ||
مراجع | ||
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