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اثر تمرینات ترکیبی (اینتروال هوازی و مقاومتی) با دو شدت مختلف بر FGF-21، آنزیمهای کبدی، مقاومت به انسولین و ترکیب بدن در زنان مبتلا به کبد چرب غیر الکلی | |
سوخت و ساز و فعالیت ورزشی | |
مقاله 3، دوره 11، شماره 1، فروردین 1400، صفحه 19-35 اصل مقاله (946.03 K) | |
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC) license I Open Access I | |
شناسه دیجیتال (DOI): 10.22124/jme.2021.18671.210 | |
نویسندگان | |
فهیمه مهربانی1؛ فرهاد رحمانی نیا* 1؛ جواد مهربانی1؛ نسرین رضویانزاده2 | |
1گروه فیزیولوژی ورزش دانشگاه گیلان | |
2استادیار دانشکده علوم پزشکی،واحد شاهرود، دانشگاه آزاد اسلامی، شاهرود، ایران | |
چکیده | |
مقدمه: کبد چرب غیرالکلی (NAFLD) وضعیتی است که در آن تجمع چربی در کبد افزایش مییابد. ورزش میتواند با جلوگیری از تجمع بیش از حد چربی در کبد به عنوان یک مداخله غیردارویی منجر به بهبود این عارضه و جلوگیری از پیشرفت بیماریهای مزمن کبدی باشد. هدف تحقیق حاضر مقایسه تاثیر تمرینات ترکیبی با شدتهای متفاوت بر FGF-21، مقاومت به انسولین، آنزیمهای کبدی و ترکیب بدن زنان مبتلا به کبد چرب بود. مواد و روشها: تعداد 33 زن مبتلا به NAFLD با میانگین سنی 75/7±45/43 سال و شاخص توده بدنی 6±84/32 کیلوگرم بر مترمربع) به صورت تصادفی به سه گروه مساوی تقسیم شدند؛ اینتروال هوازی (AIT) - تمرین مقاومتی (ترکیبی 1)، اینتروال شدید (HIIT) - تمرین مقاومتی (ترکیبی 2) و گروه کنترل. برنامه تمرینی به مدت 12 هفته و 3 جلسه در هفته انجام شد. متغیرهای پژوهش قبل و بعد از دوره تمرینی اندازه گیری شد. دادهها با استفاده از آزمون آنالیز واریانس با اندازهگیریهای مکرر (05/0p<) مورد تجزیه و تحلیل قرار گرفتند. یافتهها: نتایج نشان داد شاخص HOMA-IR و FGF-21 سرمی در گروههای تمرین ترکیبی در مقایسه با گروه کنترل بهطور معنیداری کاهش یافته بود (05/0>p). در سطوح آنزیمهای ALT و AST، اثر و تفاوت معنی داری مشاهده نشد. همچنین، کاهش معنیداری درصد چربی بدن مشاهده شد (05/0>p). نتیجهگیری: به نظر میرسد زنان مبتلا به NAFLD احتمالا بتوانند از هر دو شدت تمرین ترکیبی مقاومتی و اینتروال متوسط و شدید بهعنوان یک راهکار غیردارویی برای کاهش درصد چربی و بهبود مقاومت به انسولین و FGF-21 استفاده کنند. | |
کلیدواژهها | |
کبد چرب؛ تمرین ترکیبی؛ فاکتور رشد فیبروبلاست؛ آسپارتات آمینوترانسفراز؛ توده چربی | |
مراجع | |
1. Glass OK, Radia A, Kraus WE, Abdelmalek MF. Exercise Training as Treatment of Nonalcoholic Fatty Liver Disease. Journal of Functional Morphology and Kinesiology. 2017;2 (4):35.
|
|
2. Cassidy S, Thoma C, Houghton D, Trenell MI. High-intensity interval training: a review of its impact on glucose control and cardiometabolic health. Diabetologia. 2017;60 (1):7-23.
|
|
3. Tjønna AE and et al. Aerobic interval training vs. continuous moderate exercise as a treatment for the metabolic syndrome-“A Pilot Study”. Circulation. 2008;118(4):346.
|
|
4. Gurd BJ, Perry CG, Heigenhauser GJ, Spriet LL, Bonen A. High-intensity interval training increases SIRT1 activity in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism. 2010;35 (3):350-7.
|
|
5. Currie KD, Dubberley JB, McKELVIE RS, MacDONALD MJ. Low-volume, high-intensity interval training in patients with CAD. Medicine & Science in Sports & Exercise. 2013;45(8):1436-42.
|
|
6. Alberga AS and et al. Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial. International journal of obesity. 2015;39(10):1494-500.
|
|
7. Rajabi S. The effect of two combined training programs with different intensities on some plasma indices of liver cell death, adipkine and physical fitness factors in women with non-alcoholic fatty liver. IJOGI, 2020;23(3):69-82. (in persian)
|
|
8. Hallsworth K, Thoma C, Hollingsworth KG, Cassidy S, Anstee QM, Day CP, Trenell MI. Modified high-intensity interval training reduces liver fat and improves cardiac function in non-alcoholic fatty liver disease: a randomized controlled trial. Clinical Science. 2015; 129(12):1097-105.
|
|
9. Buckley TA & Hass CJ. Reliability in one-repetition maximum performance in people with Parkinson's disease.Parkinson’s Disease. 2012; 6.
|
|
10. Badr NM and et al. Effect of high intensity interval training versus resistance training on quality of life and functional capacity on patients with fatty liver diseases (part II). Egyptian Journal of Occupational Medicin. 2016;40 (1): 71-82.
|
|
11. Zhu S, Wu Y, Ye X, Ma L, Qi J, Yu D, Wei Y, Lin G, Ren G, Li D. FGF21 ameliorates nonalcoholic fatty liver disease by inducing autophagy. Molecular and cellular biochemistry. 2016;420(1-2):107-19.
|
|
12. Summart, Ueamporn et al. “Gender Differences in the Prevalence of Nonalcoholic Fatty Liver Disease in the Northeast of Thailand: A Population-Based Cross-Sectional Study.” F1000Research 6 2017;- :1-17
|
|
13. Katsagoni CN, Georgoulis M, Papatheodoridis GV, Panagiotakos DB, Kontogianni MD. Effects of lifestyle interventions on clinical characteristics of patients with non-alcoholic fatty liver disease: A meta-analysis. Metabolism. 2017;68:119-32.
|
|
14. Lavallard VJ, Gual P. Autophagy and non-alcoholic fatty liver disease. BioMed research international. 2014;14.
|
|
15. Rezaee Shirazi R. Effects of 12 weeks high intensity interval training on plasma Adiponectin, Leptin and insulin resistance in obese males with non-alcoholic fatty liver. Metabolism and Exercise A bioannual journal. 2016;5(1):25-36 (in Persian)
|
|
16. Gurd, B. J and et al. High-intensity interval training increases SIRT1 activity in human skeletal muscle. Applied Physiology, Nutrition, and Metabolism, 2010;35(3): 350-357 .
|
|
17. Gibala MJ and et al. Physiological adaptations to low‐volume, high‐intensity interval training in health and disease. The Journal of physiology. 2012;590(5):1077-1084 .
|
|
18. Yan H, Xia M, Chang X, Xu Q, Bian H, Zeng M, Rao S, Yao X, Tu Y, Jia W, Gao X. Circulating fibroblast growth factor 21 levels are closely associated with hepatic fat content: a cross-sectional study. PloS one. 2011;6(9):e24895.
|
|
19. Cuevas-Ramos D and et al. Daily physical activity, fasting glucose, uric acid, and body mass index are independent factors associated with serum fibroblast growth factor 21 levels. European Journal of Endocrinology. 2010;163(3):469-77.
|
|
20. Houghton D, Thoma C, Hallsworth K, Cassidy S, Hardy T, Burt AD, Tiniakos D, Hollingsworth KG, Taylor R, Day CP, McPherson S. Exercise reduces liver lipids and visceral adiposity in patients with nonalcoholic steatohepatitis in a randomized controlled trial. Clinical Gastroenterology and Hepatology. 2017;15(1):96-102.
|
|
21. Kaki A, Galedari M. The Effect of 12 Weeks high Intensity Interval Training and Resistance Training on Liver Fat, Liver Enzymes and Insulin Resistance in Men with Nonalcoholic Fatty Liver. Jundishapur Sci Med J 2017; 16(5):493-505. (in persian)
|
|
22. Pan, Jen-Jung, and Michael B Fallon. Gender and Racial Differences in Nonalcoholic Fatty Liver Disease.” World Journal of Hepatology. (2017);6(5): 274–283.
|
|
23. Barani F, Afzalpour M E, Ilbiegi S, Kazemi T, Mohammadi Fard M. The effect of resistance and combined exercise on serum levels of liver enzymes and fitness indicators in women with nonalcoholic fatty liver disease. J Birjand Univ Med Sci.2014; 21(2):188-202. (In Persian)
|
|
24. Jameson, J. L., In Kasper, D. L., In Longo, D. L., In Fauci, A. S., In Hauser, S. L., & In Loscalzo, J. Harrison's principles of internal medicine e20 - diseases of the liver and bile ducts. (2018);1;(3). (Book).
|
|
25. NAFLD, Estrogens, and Physical Exercise: The Animal Model. Journal of Nutrition and Metabolism. 2012;13.
|
|
26). Medrano M, Labayen I, Ruiz JR, Rodríguez G, Breidenassel C, Castillo M, Pedrero R, Widhalm K, Kafatos A, Manios Y, Molnar D. Cardiorespiratory fitness, waist circumference and liver enzyme levels in European adolescents: The HELENA cross-sectional study. Journal of Science and Medicine in Sport. 2017;19.
|
|
27. Kenneally S, Sier JH, Moore JB. Efficacy of dietary and physical activity intervention in non-alcoholic fatty liver disease: a systematic review. BMJ Open Gastroenterology. 2017;4(1):e000139.
|
|
28. Chun SK, Lee S, Yang MJ, Leeuwenburgh C, Kim JS. Exercise-Induced Autophagy in Fatty Liver Disease. Exercise and Sport Sciences Reviews. 2017;45(3):181-6.
|
|
29. Wainwright P, Byrne CD. Bidirectional relationships and disconnects between NAFLD and features of the metabolic syndrome. International journal of molecular sciences. 2016 ;17(3):367.
|
|
30. Hashida R and et al. Aerobic vs. resistance exercise in non-alcoholic fatty liver disease: A systematic review. Journal of hepatology. 2017;66(1):142-52.
|
31. Liu J, Xu Y, Hu Y, Wang G. The role of fibroblast growth factor 21 in the pathogenesis of non-alcoholic fatty liver disease and implications for therapy. Metabolism. 2015;64(3):380-90.
|
32. Keating SE, Hackett DA, Parker HM, O’Connor HT, Gerofi JA, Sainsbury A, Baker MK, Chuter VH, Caterson ID, George J, Johnson NA. Effect of aerobic exercise training dose on liver fat and visceral adiposity. Journal of hepatology. 2015;63(1):174-82.
|
33. Park MJ, Kim DI, Choi JH, Heo YR, Park SH. New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro. Cellular signalling. 2015;27(9):1831-9.
|
34. Slentz CA and et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American Journal of Physiology-Endocrinology and Metabolism.2011;301(5),1033-1039.
|
35. Croci I, Byrne NM, Chachay VS, Hills AP, Clouston AD, O’Moore-Sullivan TM, Prins JB, Macdonald GA, Hickman IJ. Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease. World journal of hepatology. 2016;8(27):1137.
|
36. Li H, Fang Q, Gao F, Fan J, Zhou J, Wang X, Zhang H, Pan X, Bao Y, Xiang K, Xu A. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. Journal of hepatology. 2010;53(5):934-40.
|
37. Cuevas-Ramos D, Almeda-Valdés P, Meza-Arana CE, Brito-Córdova G, Gómez-Pérez FJ, Mehta R, Oseguera-Moguel J, Aguilar-Salinas CA. Exercise increases serum fibroblast growth factor 21 (FGF21) levels. PLoS One. 2012;7(5):e38022.
|
38. Takahashi A and et al. Simple Resistance Exercise for 24 Weeks Decreases Alanine Aminotransferase Levels in Patients with Non-Alcoholic Fatty Liver Disease. Sports Medicine International Open. 2017;1(01):E2-7.
|
39. Yilmaz Y, Eren F, Yonal O, Kurt R, Aktas B, Celikel CA, Ozdogan O, Imeryuz N, Kalayci C, Avsar E. Increased serum FGF21 levels in patients with nonalcoholic fatty liver disease. European journal of clinical investigation. 2010;40(10):887-92.
|
40. Bacchi E, Negri C and et al. Both resistance training and aerobic training reduce hepatic fat content in type 2 diabetic subjects with nonalcoholic fatty liver disease (the RAED2 Randomized Trial). Hepatology, 2013;58(4):1287-1295 .
|
41. Lavallard VJ, Meijer AJ, Codogno P, Gual P. Autophagy, signaling and obesity. Pharmacological research. 2012;66(6):513-25.
|
42. Segsworth, Blair M. Acute Sprint Interval Exercise Induces a Greater FGF-21 Response in Comparison to Work-Matched Continuous Exercise. Electronic Thesis and Dissertation Repository. 2015;92:3254.
|
43. Kong Z, Sun Sh, Liu M,et al. Short-Term High-Intensity Interval Training on Body Composition and Blood Glucose in Overweight and Obese Young Women. J Diabetes Res 2016;9.
|
44. Tofighi A, Alizadeh R, Tolouei Azar J. the effect of eight weeks of high intensity interval training (HIIT) on serum amounts of fibroblast growth factor 21 (FGF21) and Irisin in sedentary obese women. URMIA MEDICAL JOURNAL. 2017;28(7):453-66. (in persian)
|
45. Shojaee-Moradie F, Cuthbertson DJ, and et al. Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD. The Journal of Clinical Endocrinology & Metabolism. 2016;101(11):4219-28.
|
46. Abdelbasset WK, Tantawy SA and et al. A randomized controlled trial on the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides, visceral lipids, and health-related quality of life in diabetic obese patients with nonalcoholic fatty liver disease. Medicine. 2019;98:12.
|
47. Hematfar A, Samavati Sharif MA and et al. Effect of a Six-week Combined Aerobic and Resistance Exercise Training on Some Liver Function Parameters in Middle-aged Men with Non-alcoholic Fatty Liver Disease. Scientific Journal of Hamadan University of Medical Sciences. 2017;24(3):206-214.
|
48. Jamart G ,Benoit N and et al. Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise. Eur J Appl Physiol. 2012;112:3173–3177.
|
49. Kooshki Fateme The Effect of Oral Supplementation of Chromium Picolinate on Liver Function, Oxidative index, Leptin and Resistin in Non-Alcoholic Fatty Liver Disease. A Thesis Submitted for Master Degree in Nutrition Sciences, Tabriz University of Medical Sciences, 2019;169. (in persian)
|
50. Win NC and et al. Energy-matched moderate and high intensity exercise training improves nonalcoholic fatty liver disease risk independent of changes in body mass or abdominal adiposity-a randomized trial. Metabolism. 2018;78:128-140.
|
51. la Fuente FP, Quezada L and et al. Exercise regulates lipid droplet dynamics in normal and fatty liver. Molecular and Cell Biology of Lipids. 2019;10.
|