اثر تعاملی تمرین هوازی و مصرف بربرین کلراید بر بیان TGF-β وSmad4 بافت قلب موش‌های صحرایی دیابتی شده با STZ

1. Afshar bakeshlou H, Abdi A, Azarbayjani M A, Barari A. Effect of aerobic exercise combined with berberine chloride hydrate on cardiac tissue of streptozotocin-diabetic rats. Iran J Diabet Met. 2020;19(2):81-92. [Full text in Persian]
2. Abdi A, sheykholeslami z, Ghorbani hasan saraee A, abaszadeh h, farzanegi p, sheykholeslami z. Effects of aerobic training with coriander seed extract on serum paraoxonase-1, TNF-α, and CRP in diabetic rats. J Neyshabur Uni Med Sci. 2018;6(1):70-80. [Full text in Persian]
3. Chang W, Zhang M, Li J, Meng Z, Xiao D, Wei S, et al. Berberine attenuates ischemia-reperfusion injury via regulation of adenosine-5′-monophosphate kinase activity in both non-ischemic and ischemic areas of the rat heart. Cardiovasc Drugs Ther. 2012;26(6):467-78.
4. Che Y, Shen D-F, Wang Z-P, Jin Y-G, Wu Q-Q, Wang S-S, et al. Protective role of berberine in isoprenaline-induced cardiac fibrosis in rats. BMC Cardiovasc Disord. 2019;19(1):1-11.
5. Di Y-F, Li D-C, Shen Y-Q, Wang C-L, Zhang D-Y, Shang A-Q, et al. MiR-146b protects cardiomyocytes injury in myocardial ischemia/reperfusion by targeting Smad4. Am J Transl Res. 2017;9(2):656.
6. Euler-Taimor G, Heger J. The complex pattern of SMAD signaling in the cardiovascular system. Cardiovasc Res. 2006;69(1):15-25.
7. Feng X, Sureda A, Jafari S, Memariani Z, Tewari D, Annunziata G, et al. Berberine in cardiovascular and metabolic diseases: from mechanisms to therapeutics. Theranostics. 2019;9(7):1923.
8. Giallauria F, Galizia G, Lucci R, D'Agostino M, Vitelli A, Maresca L, et al. Favourable effects of exercise-based Cardiac Rehabilitation after acute myocardial infarction on left atrial remodeling. Int J Cardiol. 2009;136(3):300-6.
9. Gomes AP, Duarte FV, Nunes P, Hubbard BP, Teodoro JS, Varela AT, et al. Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis. Biochim Biophys Acta Mol Basis Dis. 2012;1822(2):185-95.
10. Hosseini SE, Karimzadeh K. Anti-diabetic effects of hydroalcohlic juglans regia male flower extract on blood glucose level and on liver enzymes activity in intact and diabetogenized adult male rat. J Birjand Uni Med Sci. 2012;19(2):165-72. [Full text in Persian]
11. Hu X, Bai T, Xu Z, Liu Q, Zheng Y, Cai L. Pathophysiological fundamentals of diabetic cardiomyopathy. Compr Physiol. 2011;7(2):693-711.
12. Ikeuchi M, Tsutsui H, Shiomi T, Matsusaka H, Matsushima S, Wen J, et al. Inhibition of TGF-β signaling exacerbates early cardiac dysfunction but prevents late remodeling after infarction. Cardiovasc Res. 2004;64(3):526-35.
13. Jia G, Hill MA, Sowers JR. Diabetic cardiomyopathy: an update of mechanisms contributing to this clinical entity. Circ Res. 2018;122(4):624-38.
14. Li X, Zhang Z-L, Wang H-F. Fusaric acid (FA) protects heart failure induced by isoproterenol (ISP) in mice through fibrosis prevention via TGF-β1/SMADs and PI3K/AKT signaling pathways. Biomed Pharmacother. 2017;93:130-45.
15. Mahmoud AM, Abdel-Rahman MM, Bastawy NA, Eissa HM. Modulatory effect of berberine on adipose tissue PPARγ, adipocytokines and oxidative stress in high fat diet/streptozotocin-induced diabetic rats. J Applied Pharm Sci. 2017;7(04):001-10.
16. Mehdipoor M, Damirchi A, Razavi Tousi SMT, Babaei P. Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats. J Physiol Biochem. 2021;77(1):75-84.
17. MM HT, Hassanpour Fard M, Abolghasemi A, Ahmadi N, Hosseini M. Effect of Fitana Herbal Compound on Weight and Blood Lipid Profile of Male Wistar Rats. Horizon Med Sci. 2013;19(2):77-82.
18. Moghadam V, Piri M, Azarbayjani MA, Matin Homaee H. The protective effect of aerobic exercise on breast cancer by TGFβ protein and Smad-3 and MMP2 gene in female mice. Sci J Kurdistan uni med sci. 2017;22(3):60-73. [Full text in Persian]
19. Ogurtsova K, da Rocha Fernandes J, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40-50.
20. Ren L, Sen U, Pushpakumar S. Exercise training reduces TGF‐β mediated epithelial mesenchymal transition in diabetic kidney. FASEB J. 2017;31:1086.5-.5.
21. Sadighi A, Abdi A, Azarbayjani MA, Barari A. Effect of Aerobic Training and Berberine Chloride Supplementation on Oxidative Stress Indices in the Heart Tissue of Streptozotocin-Induced Diabetic Rats. J ilam uni med sci. 2020;28(4):54-65. [Full text in Persian]
22. Sadighi A, Azarbayjani MA. Response of Some Apoptotic Indices to Six Weeks of Aerobic Training in Streptozotocin-Induced Diabetic Rats. Med Lab J. 2021;15(1):33-9.
23. Shah MS, Brownlee M. Molecular and cellular mechanisms of cardiovascular disorders in diabetes. Circ Res. 2016;118(11):1808-29.
24. Silva E, Natali AJ, Silva MF, Gomes GJ, Cunha DN, Ramos RM, et al. Ventricular remodeling in growing rats with experimental diabetes: The impact of swimming training. Pathol Res Pract. 2013;209(10):618-26.
25. Siraj AK, Pratheeshkumar P, Divya SP, Parvathareddy SK, Bu R, Masoodi T, et al. TGFβ-induced SMAD4-dependent apoptosis proceeded by EMT in CRC. Mol Cancer Ther. 2019;18(7):1312-22.
26. Stratmann B, Tschoepe D. Heart in diabetes: not only a macrovascular disease. Diabetes care. 2011;34(Supplement_2):S138-S44.
27. Wang H, Bei Y, Lu Y, Sun W, Liu Q, Wang Y, et al. Exercise prevents cardiac injury and improves mitochondrial biogenesis in advanced diabetic cardiomyopathy with PGC-1α and Akt activation. Cell Physiol Biochem. 2015;35(6):2159-68.
28. Wisløff U, Helgerud J, Kemi OJ, Ellingsen Ø. Intensity-controlled treadmill running in rats: V̇ o 2 max and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2001;280(3):H1301-H10.
29. Xiao L, He H, Ma L, Da M, Cheng S, Duan Y, et al. Effects of miR-29a and miR-101a expression on myocardial interstitial collagen generation after aerobic exercise in myocardial-infarcted rats. Arch Med Res. 2017;48(1):27-34.
30. Xie F, Ling L, van Dam H, Zhou F, Zhang L. TGF-β signaling in cancer metastasis. Acta Biochim Biophys Sin. 2018;50(1):121-32.
31. Yang H, Shang X, Zhong G, Hong L, Li Z, Zhuang W, et al. Berberine protects human and rat cardiomyocytes from hypoxia/reoxygenation-triggered apoptosis. Am J Transl Res. 2021;13(2):659.
32. Zhao M, Mishra L, Deng C-X. The role of TGF-β/SMAD4 signaling in cancer. Int J Biol Sci. 2018;14(2):11.

33. Zhu Q-e, editor. The Role and Mechanism of Exercise for Prevention of Myocardial Fibrosis in Diabetes. 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018); 2018: Atlantis Press.