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Baratova, Mehriban S., Ulashov, Ilhom A., Yakhshieva, Zukhra, Egamberdiev, Alimardon A., Хoshimov, Botirbek, Kodirov, Umid A., Eshmuratov, Ajiniyaz A., Avilova, Klara X., Mamadoliev, Ikromjon I., Normurodov, Davlat. (1403). Protective effects of 1, 8-cineole (eucalyptol) against CCl4-induced hepatic oxidative damage in rats. فیزیولوژی و بیوتکنولوژی آبزیان, (), 1-9. doi: 10.22124/cjes.2025.8607
Mehriban S. Baratova; Ilhom A. Ulashov; Zukhra Yakhshieva; Alimardon A. Egamberdiev; Botirbek Хoshimov; Umid A. Kodirov; Ajiniyaz A. Eshmuratov; Klara X. Avilova; Ikromjon I. Mamadoliev; Davlat Normurodov. "Protective effects of 1, 8-cineole (eucalyptol) against CCl4-induced hepatic oxidative damage in rats". فیزیولوژی و بیوتکنولوژی آبزیان, , , 1403, 1-9. doi: 10.22124/cjes.2025.8607
Baratova, Mehriban S., Ulashov, Ilhom A., Yakhshieva, Zukhra, Egamberdiev, Alimardon A., Хoshimov, Botirbek, Kodirov, Umid A., Eshmuratov, Ajiniyaz A., Avilova, Klara X., Mamadoliev, Ikromjon I., Normurodov, Davlat. (1403). 'Protective effects of 1, 8-cineole (eucalyptol) against CCl4-induced hepatic oxidative damage in rats', فیزیولوژی و بیوتکنولوژی آبزیان, (), pp. 1-9. doi: 10.22124/cjes.2025.8607
Baratova, Mehriban S., Ulashov, Ilhom A., Yakhshieva, Zukhra, Egamberdiev, Alimardon A., Хoshimov, Botirbek, Kodirov, Umid A., Eshmuratov, Ajiniyaz A., Avilova, Klara X., Mamadoliev, Ikromjon I., Normurodov, Davlat. Protective effects of 1, 8-cineole (eucalyptol) against CCl4-induced hepatic oxidative damage in rats. فیزیولوژی و بیوتکنولوژی آبزیان, 1403; (): 1-9. doi: 10.22124/cjes.2025.8607

Protective effects of 1, 8-cineole (eucalyptol) against CCl4-induced hepatic oxidative damage in rats

Caspian Journal of Environmental Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 23 اسفند 1403
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22124/cjes.2025.8607
نویسندگان
Mehriban S. Baratova1؛ Ilhom A. Ulashov* 2؛ Zukhra Yakhshieva3؛ Alimardon A. Egamberdiev4؛ Botirbek Хoshimov5؛ Umid A. Kodirov6؛ Ajiniyaz A. Eshmuratov7؛ Klara X. Avilova8؛ Ikromjon I. Mamadoliev9؛ Davlat Normurodov10
1Candidate of Medical Sciences, Associate Professor - Head of the Department of Public Health, Healthcare Management, Bukhara State Medical Institute, Uzbekistan
2PhD in Veterinary Sciences, Senior Researcher at the Helminthology Laboratory, Veterinary Scientific Research Institute, Taylok region, Samarkand, Uzbekistan
3Doctor of Chemical Sciences, Professor, Jizzakh State Pedagogical University, Jizzakh, Uzbekistan
4Assistant, Department of "Engineering Graphics and Design Theory", "Tashkent Institute of Irrigation and Agricultural Mechanization Engineers", National Research University, Tashkent, Uzbekistan
5Doctor of Philosophy (PhD Veterinary Science), Department of Agronomy, Navoi State University of Mining and Technologies, Navoi, Uzbekistan
6Teacher at the Department of Neurology, Faculty of Postgraduate Education, Samarkand State Medical University, Samarkand, Uzbekistan
7Lecturer, Department of Art Science, Karakalpak State University named after Berdakh, Nukus, Republic of Karakalpakstan
8Senior Teacher, Department of Pharmaceuticals and Chemistry, Faculty of Medicine, Alfraganus University, Tashkent, Uzbekistan
9Kimyo International University in Tashkent, Tashkent, Uzbekistan
10Professor, Institute of Agrobiotechnology and Food Securite of Samarkand State University named after Sharof Rashidov, Jamboy district, Samarkand, Uzbekistan
چکیده
Carbon tetrachloride (CCl₄) is a hepatotoxin that induces oxidative stress. Therefore, supplementation with antioxidants may be beneficial in mitigating its hepatotoxic effects. 1,8-Cineole (1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane), commonly called eucalyptol, has various therapeutic properties. Hence, this research was conducted to evaluate the protective effects of eucalyptol against CCl4-induced hepatic oxidative damage in rats. Thirty rats were divided randomly into the following three equal groups (n = 10): Healthy control, CCl4 poisoned group (1 mL/kg BW dissolved in olive oil (1:1 volume)), and eucalyptol treated group (100 mg/kg/day). After treatment period (14 days), serum sample was prepared and liver was taken out for measurement of biochemical parameters including liver enzymes (Alanine transaminase (ALT) and Aspartate transaminase (AST) as well as oxidative stress markers including Malondialdehyde (MDA), Glutathione (GSH), Catalase (CAT), Superoxide dismutase (SOD) and Glutathione Peroxidase (GPX). The results showed that following CCl4 poisoning, a significant reduction in the levels of GSH, GPX, CAT and SOD was observed in the CCl4 -poisoned group compared to the control group, and a significant elevation in the levels of AST, ALT and MDA was observed in the CCl4-poisoned group in comparison with the control group (p < 0.05). Furthermore, there was a significant increase in the levels of GSH, GPX, CAT and SOD in the eucalyptol treated group compared to the CCl4 -poisoned group. However, there was a significant decrease in the levels of AST and ALT in the eucalyptol-treated group compared to the CCl4-poisoned group (p<0.05). However, there was no significant in the levels of MDA in the eucalyptol treated group compared to the CCl4 -poisoned group (p > 0.05). Eucalyptol may be effective in the prevention of CCl4-induced liver damage through the reduction of oxidative stress, liver damage caused by elevated liver enzymes, and increasing antioxidant enzymes.
کلیدواژه‌ها
Eucalyptol؛ 1؛ 8-Cineole؛ Antioxidants؛ Hepatic damage؛ CCl4؛ Oxidative stress
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