دانشگاه گیلان
معاونت پژوهش و فناوری دانشگاه گیلان
انتشارات دانشگاه گیلان

 آمار

تعداد نشریات31
تعداد شماره‌ها778
تعداد مقالات7,442
تعداد مشاهده مقاله18,297,085
تعداد دریافت فایل اصل مقاله7,495,500
Islamova, Saidakhon T., Nazarova, Moxira A., Burkhanov, Aktam U., Khamraev, Fayzulla, Isagova, B.U., Xamdamov, Sherali, Nazarova, Nodira Sh., Zubaydov, Fazliddin F., Khursandova, Dilafruz S., Badriddinov, Oyatillo U.. (1403). Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels. فیزیولوژی و بیوتکنولوژی آبزیان, (), 1-10. doi: 10.22124/cjes.2025.8570
Saidakhon T. Islamova; Moxira A. Nazarova; Aktam U. Burkhanov; Fayzulla Khamraev; B.U. Isagova; Sherali Xamdamov; Nodira Sh. Nazarova; Fazliddin F. Zubaydov; Dilafruz S. Khursandova; Oyatillo U. Badriddinov. "Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels". فیزیولوژی و بیوتکنولوژی آبزیان, , , 1403, 1-10. doi: 10.22124/cjes.2025.8570
Islamova, Saidakhon T., Nazarova, Moxira A., Burkhanov, Aktam U., Khamraev, Fayzulla, Isagova, B.U., Xamdamov, Sherali, Nazarova, Nodira Sh., Zubaydov, Fazliddin F., Khursandova, Dilafruz S., Badriddinov, Oyatillo U.. (1403). 'Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels', فیزیولوژی و بیوتکنولوژی آبزیان, (), pp. 1-10. doi: 10.22124/cjes.2025.8570
Islamova, Saidakhon T., Nazarova, Moxira A., Burkhanov, Aktam U., Khamraev, Fayzulla, Isagova, B.U., Xamdamov, Sherali, Nazarova, Nodira Sh., Zubaydov, Fazliddin F., Khursandova, Dilafruz S., Badriddinov, Oyatillo U.. Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels. فیزیولوژی و بیوتکنولوژی آبزیان, 1403; (): 1-10. doi: 10.22124/cjes.2025.8570

Antibacterial and antioxidant effects of Punicalagin extracts from Punica granatum peels

Caspian Journal of Environmental Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 13 اسفند 1403
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22124/cjes.2025.8570
نویسندگان
Saidakhon T. Islamova1؛ Moxira A. Nazarova2؛ Aktam U. Burkhanov3؛ Fayzulla Khamraev4؛ B.U. Isagova5؛ Sherali Xamdamov6؛ Nodira Sh. Nazarova7؛ Fazliddin F. Zubaydov8؛ Dilafruz S. Khursandova9؛ Oyatillo U. Badriddinov10
1PhD, Associate Professor of the Medical Chemistry Department, Andijan State Medical Institute. Uzbekistan
2Doctor of Philosophy in Agricultural Sciences (PhD), Senior lecturer of the Department of "Animals, Genetics, Breeding and Feeding Technology", Samarkand State University of Veterinary, Animal Husbandry and Biotechnology, Samarkand, Uzbekistan
3DSc in Economics, Professor International School of Finance and Technology, Tashkent, Uzbekistan; Alfraganus University, Tashkent, Uzbekistan
4PhD in Biology, Department of Agronomy, Navoi State University of Mining and Technologies, Navoi, Uzbekistan
5Specialist of the Department of Science and Innovation, Western Caspian University, Baku, Azerbaijan
6Kimyo international university in Tashkent Shota Rustaveli street 156, 100121, Тashkent, Uzbekistan
7DSc, Professor of the Department of Dentistry Faculty of Postgraduate Education, Samarkand State Medical University, Samarkand, Uzbekistan
8PhD in Veterinary Sciences, Junior Researcher, Virology Laboratory, Veterinary Scientific Research Institute, Taylok region, Samarkand, Uzbekistan
9Independent Researcher of the Department of "Engineering Graphics and Design Theory" of the National Research University "Tashkent Institute of Irrigation and Agricultural Mechanization Engineers" Tashkent, Uzbekistan
10Assistant of the Department of Pathological Physiology and Pathological Anatomy, Fergana Medical Institute of Public Health, Fergana, Uzbekistan
چکیده
The growing recognition of the health-promoting potential of compounds derived from natural sources, particularly those exhibiting antimicrobial and antioxidant activities, has resulted in a surge of research publications dedicated to exploring the functional attributes of these target compounds for applications in functional foods and preventive healthcare. Pomegranate has been identified as a source of beneficial health effects attributed to its rich content of bioactive components, including polyphenols, tannins, and anthocyanins. This study investigates the effects of Punicalagin on the viability and proliferation of A549 cells, a human alveolar basal epithelial adenocarcinoma cell line. The cells were treated with varying concentrations of Punicalagin (10, 25, 50, 100, and 200 μg/mL) and punicalagin, with assessments conducted after a 72-hour incubation period. Cell viability was evaluated using the MTT assay, which measures metabolic activity, and results indicated a dose-dependent response to Punicalagin treatment. Specifically, lower concentrations (10 μg/mL) exhibited minimal cytotoxicity (viability: 86.04± 3.09%), while higher concentrations (200 μg/mL) significantly reduced cell viability to 51.17± 0.94%, indicating cytotoxic effects at elevated doses. Additionally, the study highlighted that even at non-cytotoxic concentrations, treated cells displayed reduced proliferative potential compared to control groups, suggesting that Punicalagin may impair cell growth. Punicalagin treatment also demonstrated a similar trend, where higher concentrations negatively impacted cell proliferation. The findings underscore the importance of concentration in determining the cytotoxic and proliferative effects of these compounds on A549 cells, providing insights into their potential therapeutic applications and mechanisms of action. Overall, this research contributes to the understanding of how natural compounds like punicalagin can influence cancer cell behavior, paving the way for future studies aimed at developing effective cancer treatments.
کلیدواژه‌ها
Anti-bacterial؛ Antioxidant؛ Punicalagin؛ MTT assay
آمار
تعداد مشاهده مقاله: 138


سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب