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Morphometric changes in the heart of rats with alloxan and streptozotocin diabetes | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 22، شماره 5، اسفند 2024، صفحه 1199-1206 اصل مقاله (650.07 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.8337 | ||
| نویسندگان | ||
| Saule Zhautikova1؛ Kulash Nurseitova2؛ Lyubov Piven3؛ Tatyana Kim3؛ Irina Baryshnikova1؛ Gulnur Bakaramova1؛ Arailym Amantayeva* 4؛ Zhadyra Orynbayeva4 | ||
| 1Karaganda Medical University, Department of Physiology, Karaganda, Kazakhstan | ||
| 2Karaganda Medical University, Department of Morphology, Karaganda, Kazakhstan | ||
| 3Karaganda Medical University, Department of Clinical Pharmacology and Evidence-Based Medicine, Karaganda, Kazakhstan | ||
| 4Abai Kazakh National Pedagogical University, Department of Biology, Faculty of Natural Sciences and Geography, Almaty, Kazakhstan | ||
| چکیده | ||
| In diabetes mellitus (DM), the ability of the myocardium to fully relax and fill with blood during diastole is impaired. Clinical observations by various authors confirm the presence of myocardial hypertrophy in patients with diabetes; in particular, an increase in the thickness of its posterior wall and interventricular septum has been established. In this regard, of undoubted interest is the study of the relationships between the frequency, structure, and severity of pathogenetic morphometric disorders of the heart in animals with experimental models of alloxan and streptozotocin diabetes. This study aimed to study morphometric changes in the heart in animals at different stages of development using models of experimental alloxan and streptozotocin diabetes. In this study, 450 rats with experimental diabetes were studied (intravenous administration of alloxan 35 mg kg-1): Model 1: alloxan diabetes (group A): divided into subgroups: A1: 6 months of observation (50 animals in each subgroup); A2: 12 months; A3: 24 months; Model 2: streptozotocin diabetes (group C): C1: 6 months; C2: 12 months; C3: 24 months. CI: control group of intact rats: CI1: 6 months (30 individuals per subgroup); CI2: 12 months; KI3: 24 months. They received a single injection of sterile saline solution into the femoral vein. Morphometric studies, volumetric ratios of tissue components were determined using an ocular measuring grid for cytohistostereometric studies. Avtandilova Statistical methods were used for studying the significance of the linear correlation coefficient (Pearson) and the rank coefficient (Spearman), then checked based on Student's t-test. In this study, upon extraction, the animal's heart was processed, dried, and weighed on a torsion balance. Weight in animals KI1 heart weight was 3.5 g with a total weight of 195.4 g. In animals with intravenous administration of alloxan, the heart weight (p < 0.05) was in the range of 3.7-3.9 g with a total weight of 194.4 -195.7 g in streptozotocin diabetes, the weight of rats heart (p < 0.05) was 4.0-4.1 g with a total weight of 193.2-193.5 g. In a morphometric study of experimental animals' right and left ventricles and pulmonary arteries, the indicators were higher in group A3. The volume of right ventricle in alloxan-induced diabetes was significantly (p < 0.05) greater than in the control groups. In the case of morphometric indicators of the rats heart with streptozotocin diabetes, pronounced ultrastructural changes distinguished cardiomyocytes. Lysis of cristae and outer mitochondrial membranes with the formation of myelin figures and dense protein bodies, were observed for alloxan diabetes at 24 months. Processes of hypertrophy of cardiomyocytes prevailed; nuclei volume increased (p < 0.05) by 34.6%, and euchromatin content and mitochondria increased by 23.8%. | ||
| کلیدواژهها | ||
| Experimental diabetes mellitus: Alloxan, Streptozotocin؛ Morphometric parameters, Heart | ||
| مراجع | ||
|
Abarnadevika, A, Mathuraveendran, T, Ariharasivakumar, G & Srinidhi, R 2024, Evaluation of antidiabetic activity of methanolic leaf extract of Nephelium lappaceum L. against Streptozotocin-Nicotinamide induced type-II diabetes in Wistar albino rats. Research Journal of Pharmacy and Technology, 17: 1376-1381, DOI: 10.52711/0974-360X.2024.00217.
Alekseenko, SN & Drobot, EV 2012, Epidemiology of diabetes mellitus in the world latest data. Bulletin of Medical Sciences, 6: 42-49.
Bolaffi, JL, Nagamatsu, S, Harris, JA & Grodsky, GM 1987, Protection by thymidine, an inhibitor of polyadenosine diphosphate ribosylation, of streptozotocin inhibition of insulin secretion. Endocrinology, 120: 2117-2122, DOI: 10.1210/endo-120-5-2117.
Choudhari, G, Choudhari, V, Pawar, A & More, C 2024, Evaluation of antidiabetic, antihyperlipidemic potential and herb-drug interaction of Saptarangi plus Kadha and Saptarangi tablet in Streptozotocin induced diabetic rats. Research Journal of Pharmacy and Technology, 17: 2164-2171, DOI: 10.52711/0974-360X.2024.00341.
De Fronzo, RA 2009, From the triumvirate to the ominous octet: A new paradigm for the treatment of type 2 diabetes mellitus. Diabetes, 58: 773-795, DOI: 10.2337/db09-9028.
Dreval, AV, Komerdus, IV, Murzina, AV, Nechaeva, OA, Tishenina, RS, Borodina, EG & Anashkina, GA 2014, The prevalence of subclinical hypercorticism among the patients presenting with type 2 diabetes mellitus and alimentary obesity. Problems of Endocrinology, 60: 9-17. DOI:10.14341/probl20146019-17.
Elsner, M, Guldbakke, B, Tiedge, M, Munday, R & Lenzen, S 2000, Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia, 43: 1528-1533. DOI: 10.1007/s001250051564.
Eshniyazov, NB, Medovshchikov, VV, Safarova, AF, Khasanova, ER & Kobalava, ZhD 2020, Frequency, clinical characteristics and echocardiographic phenotypes of heart failure in patients with type 2 diabetes mellitus. Medical Journal of Clinical Pharmacology and Therapy, 4: 44-48, DOI:10.32756/0869-5490-2020-4-44-48.
Jadhav, GB, Deshmukh, AC & Mundlod, KN 2020, Effect of Linagliptin and Niclosamide on Streptozotocin Induced Diabetic Neuropathy in Rats. Research Journal of Pharmacy and Technology, 13: 2101-2106. DOI: 10.5958/0974-360X.2020.00378.9.
Jaynthi, B, Parameshwar, P, Baba, MD, Patil, KP & Cheranjeevi, G 2012, Effect of insulin sensitizer, rosiglitazone in streptozotocine induced diabetic db/db mice model. Research Journal of Pharmacy and Technology, 5: 619-623.
Kahn, SE, Cooper, ME & Del Prato, S 2014, Pathophysiology and treatment of type 2 diabetes: Perspectives on the past, present, and future. Lancet, 383: 1068-1083. DOI:10.1016/S0140-6736(13)62154-62156.
Kelechi, TN, Comfort, CM & Frank, O 2014, Management of diabetes mellitus with combined therapy of reducdyn and metformin in streptozotocin-induced diabetic rats. Research Journal of Pharmacy and Technology, 7: 39-43.
Khandekar, T & Pradhan, NK 2023, The impact of Jussiaea repens aqueous extract on Hyperglycemic and Hematological markers in Diabetic male rat induced by Streptozotocin. Research Journal of Pharmacy and Technology, 16: 4999-5004. DOI: 10.52711/0974-360X.2023.00809.
Kornienko, EA, Oinotkinova, OSh, Baranov, AP, Goncharova, EI & Ivanov, DV 2015, Modern views on the etiopathogenesis of myocardial infarction in type 2 diabetes mellitus and treatment methods (literature review). Bulletin of New Medical Technologies, 2: 1-10, DOI: 10.12737/11912.
Lomaeva, SV, Gette, IF, Bulavintseva, TS, Perevedentseva, SE & Danilova, IG 2013, Correction of destructive changes in connective tissues in macrophage activation in alloxan diabetes. Journal of Medical Sciences, 12: 38-42. DOI :10.20538/1682-0363-2013-6-38-42.
Medovshchikov, VV, Eshniyazov, NB, Khasanova, ER, Vatsik, MV, Tukhsanboev, ES & Babaeva, LA 2020, First identified type 2 diabetes mellitus and prediabetes in hospitalized patients with cardiovascular diseases: frequency, compliance of baseline levels of blood pressure, lipids and HbA1c with target values. Medical Journal of Clinical Pharmacology and Therapy, 4: 31-35, DOI:10.32756/0869-5490-2020-4-31-35.
Mohammed, RN, Ramadhan, HH & Shari, FH 2021, Hypoglycemic, hypolipidemic, renal protective and antioxidant activity of Annona muricata in streptozotocin-induced diabetic rats. Research Journal of Pharmacy and Technology, 14(12): 6484-6490. DOI: 10.52711/0974-360X.2021.01121.
Natarajan, K, Nisha, SC, Jawahar, KN & Shakthi, NM 2024, Effect of Mucuna cochinchinensis seed extract on alloxan-induced diabetic experimental rats. Research Journal of Pharmacy and Technology, 17(3): 1185-1189. DOI: 10.52711/0974-360X.2024.00184.
Nikulina, ED, Pleshanov, AS, Muminov, KD, Antonova, LM, Fedorova, NP & Proshina, LG 2011, State of the myocardium and peripheral blood during alloxan diabet. Journal of Medical Sciences, 13: 373-374.
Nwauche, KT, Monago, CC & Anacletus, FC, 2014, Management of Diabetic induced Hyperlipidemia with Combined Therapy of Reducdyn and Metformin in Streptozotocin induced Diabetic Male Rats. Research Journal of Pharmacy and Technology, 7(9): 1041-1045.
Pavlikova, EP, Sorokina, AG & Potapenko, AV 2020, Prevention of the development of type 2 diabetes mellitus in patients with chronic heart failure. Medical Journal of Clinical Pharmacology and Therapy, 1: 67-74, DOI: 10.32756/0869-5490-2020-1-67-74.
Preethikaa, S & Brundha, MP 2018, Awareness of diabetes mellitus among general population. Research Journal of Pharmacy and Technology, 11: 1825-1829, DOI: 10.5958/0974-360X.2018.00339.6.
Preethikaa, S & Brundha, MP 2018, Awareness of diabetes mellitus among general population. Research Journal of Pharmacy and Technology, 11(5): 1825-1829, DOI: 10.5958/0974-360X.2018.00339.6.
Radenković, M, Stojanović, M & Prostran, M 2016, Experimental diabetes induced by alloxan and streptozotocin: The current state of the art. Vascular Pharmacology, 78: 13-31. DOI:10.1016/j.vascn.2015.11.004.
Ravi, K, Jose, R, Sumitha, SK, Johny, T, Krishnaveni, K, Sundaram, RS & Kumar, RS 2017, An overview of treatment challenges and the role of herbal antioxidants in diabetes mellitus. Research Journal of Pharmacy and Technology, 10(8): 2765-2770. DOI: 10.5958/0974-360X.2017.00490.5.
Rekha, S, Divekar, K & Chandrashekhara, S 2022, The hypoglycemic and hypolipidemic effect of 5-Naphthalidin-2,4 Thiazolidinedione derivatives in alloxan induced type ii diabetic model. Research Journal of Pharmacy and Technology, 15(4): 1505-1511. DOI: 10.52711/0974-360X.2022.00250.
Rosenstock, J, Zinman, B, Murphy, LJ, Clement, SC, Moore, P, Bowering, CK, Hendler, R, Lan, SP & Cefalu, WT 2005, Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial. Annals of Internal Medicine, 143: 549-558. DOI: 10.7326/0003-4819-143-8-200510180-00000.
Sanchez-Rangel, E & Inzucchi, S 2017, Metformin: clinical use in type 2 diabetes. Diabetologia, 60: 1586-1593. DOI:10.1007/s00125-017-4336-x.
Sivasankari, V & Manivannan, E 2023, Effect of Teneligliptin in comparison with Voglibose as an add on therapy in reducing microvascular complications in type II Diabetes Mellitus patients – A Prospective randomized control trial. Research Journal of Pharmacy and Technology, 16(12): 5906-5911. DOI: 10.52711/0974-360X.2023.00957.
Sumin, AN, Bezdeneshnykh, NA, Fedorova, NV, Bezdeneshnykh, AV, Indukaeva, EV & Artamonova, GV 2018, Management of cardiovascular risk in patients with type 2 diabetes mellitus. Scientific and Practical Journal of Clinical Medicine, 96: 696-701, DOI: 10.18821/0023-2149-2018-96-2-137-146.
Supomo, S, Syamsul, ES, Saadah, H, Kintoko, K & Witasari, HA 2024, Antidiabetic activity of Akar Kuning (Fibraurea tinctoria Lour) Extract in Alloxan-Induced Diabetic White Male Rats. Research Journal of Pharmacy and Technology, 17: 379-384, DOI: 10.52711/0974-360X.2024.00059.
Szkudelski, T 2001, The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiological Research, 50: 537-546. DOI: 11829314.
Vasantha, G, Dayakar, CH, Vasudha, D, Tejolahari, I & Chandrika, SB 2024, Reduced Progression of Diabetic Nephropathy in Streptozocin-Induced Diabetic rats by Lannea coromandelica Leaf Extract. Research Journal of Pharmacy and Technology, 17: 120-126. DOI: 10.52711/0974-360X.2024.00019.
Volkova, NI, Antonenko, MI & Ganenko, LA 2012, Type 2 diabetes mellitus: a new indication for hypercorticism screening. Diagnosis, control and treatment. Bulletin of Medical Sciences, 4: 95-102.
Wu, Y, Ding, Y, Tanaka, Y & Zhang, W 2014, Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention. International Journal of Medical Sciences, 11: 1185-1200. DOI:10.7150/ijms.1000.
Zvenigorodskaya, LA, Mkrtumyan, A, Shinkin, MV, Nilova, T, Silverstova, S, Varvanina, G & Petrakov, A 2021, The clinical significance of the key components of the adipo-cardiovascular axis in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease is effective pharmacotherapy. Endocrinology, pp. 26-36. DOI: 10.33978/2307-3586-2021-17-20-26-36. | ||
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