پیوندهای مفید
آمار
| تعداد نشریات | 31 |
| تعداد شماره‌ها | 766 |
| تعداد مقالات | 7,262 |
| تعداد مشاهده مقاله | 10,626,361 |
| تعداد دریافت فایل اصل مقاله | 7,095,310 |
Hesperidin, a flavone glycoside isolated from citrus fruits, can be used to facilitate Chlorpyrifos pollution side effect | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 22 آذر 1403 اصل مقاله (710.17 K) | ||
| نوع مقاله: Reviewers | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.8222 | ||
| نویسندگان | ||
| Osaid T. Al Meanazel1؛ Mohammad I. Alharasees2؛ Lama M. Al-Tarawneh3؛ Sahar Al-Habahbeh4؛ Nadine N. Abdelhadi5؛ I.B. Sapaev6؛ Shouket A. Tilwani* 7 | ||
| 1Department of Pharmacy, Faculty of Pharmacy, Jadara University, Irbid, Jordan | ||
| 2Department of Agricultural Sciences, Part-time Lecturer at Al-shoubak University College, Al-Balqa Applied University, Jordan | ||
| 3Department of Agricultural Sciences, Part-time Lecturer, Al-shoubak University College, Al-Balqa Applied University, Jordan | ||
| 4Department of Service courses, Faculty of Art and Science, Lecturer at Aqaba University of Technology Aqaba, Jordan | ||
| 5Department of clinical pharmacy and pharmacy practice , Faculty of pharmacy, Aqaba University of Technology . Jordan | ||
| 6Head of the Department «Physics and Chemistry», “Tashkent Institute of Irrigation and Agricultural Mechanization Engineers” National Research University, Tashkent, Uzbekistan & Scientific researcher, University of Tashkent for Applied Sciences, Tashkent, Uzbekistan & Western Caspian University, Scientific researcher, Baku, Azerbaijan | ||
| 7College of Science and Humanities, Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia | ||
| چکیده | ||
| Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture. It poses significant health risks due to its neurotoxic, hepatotoxic, and reproductive effects. Given that current treatments for the health problems caused by hazardous toxins are inadequate and highlight the need for new treatments, this study investigated the effects of hesperidin, a flavonoid from citrus fruits, in reducing the harmful effects of CPF exposure. Based on the results, hesperidin treatment significantly improved cell viability and reduced oxidative damage markers such as malondialdehyde (MDA) and superoxide dismutase (SOD) levels, along with oxidative stress factors. It can augment the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway besides reducing inflammatory targets and inhibiting lipid peroxidation. Histopathological analysis of the organs showed that hesperidin reduced inflammation and collagen accumulation in liver tissue, suggesting its protective role in maintaining liver structure. Furthermore, hesperidin appears to counteract the pro-apoptotic effects of CPF, as evidenced by lower levels of cell death markers. These findings highlight the potential of hesperidin as a therapeutic agent against CPF-induced damage and emphasize its antioxidant and anti-inflammatory properties. This study supports further research into hesperidin and similar plant compounds as potential solutions to pesticide-related health issues. This research advances our understanding of how natural substances can mitigate the harmful effects of environmental pollutants and paves the way for future studies in this area. | ||
| کلیدواژه‌ها | ||
| Chlorpyrifos؛ Side effects؛ Hesperidin؛ Organs | ||
| مراجع | ||
|
(EFSA), EFSA, Brancato, A, Brocca, D, De Lentdecker, C, Erdos, Z, Ferreira, L, Greco, L, Jarrah, S, Kardassi, D & Leuschner, R 2017, Review of the existing maximum residue levels for chlorpyrifos according to Article 12 of Regulation (EC) No 396/2005. European Food Safety Authority European Food Safety Authority, 15: e04733.
Ahmad, MF, Ahmad, FA, Alsayegh, AA, Zeyaullah, M, AlShahrani, AM, Muzammil, K, Saati, AA, Wahab, S, Elbendary, EY, Kambal, N, Abdelrahman, MH & Hussain, S 2024, Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures. Heliyon, 10: e29128.
Aja, PM, Ekpono, EU, Awoke, JN, Famurewa, AC, Izekwe, FI, Okoro, EJ, Okorie, CF, Orji, CL, Nwite, F, Ale, BA, Aku, AF, Igwenyi, IO, Nwali, BU, Orji, OU, Ani, OG, Ozoemena, CR & Anizoba, GC 2020, Hesperidin ameliorates hepatic dysfunction and dyslipidemia in male Wistar rats exposed to cadmium chloride. Toxicology Reports, 7: 1331-1338.
Al-Goblan, AS, Al-Alfi, MA & Khan, MZ 2014, Mechanism linking diabetes mellitus and obesity. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 7: 587-591.
Alavanja, MCR 2009, Introduction: Pesticide use and exposure are extensive worldwide. Reviews on Environmental Health, 24: 303-309.
Atoki, AV, Aja, PM, Ondari, EN & Awuchi, CG 2023, Hesperidin plays beneficial roles in disorders associated with the central nervous system: a review. International Journal of Food Properties, 26: 1867-1884.
Banerjee, BD, Pasha, ST, Hussain, QZ, Koner, BC & Ray, A 1998, A comparative evaluation of immunotoxicity of malathion after subchronic exposure in experimental animals. Indian Journal of Experimental Biology, 36: 273-282.
Barzi, NV, Eftekhari, Z, Doroud, D & Eidi, A 2020, DNA methylation changes of apoptotic genes in organogenesis stage of mice embryos by maternal chlorpyrifos induction. Environmental Toxicology, 35: 794-803.
Bernal-González, KG, Covantes-Rosales, CE, Camacho-Pérez, MR, Mercado-Salgado, U, Barajas-Carrillo, VW, Girón-Pérez, DA, Montoya-Hidalgo, AC, Díaz-Resendiz, KJG, Barcelos-García, RG, Toledo-Ibarra, GA & Girón-Pérez, MI 2023, Organophosphate-Pesticide-Mediated Immune Response Modulation in Invertebrates and Vertebrates. International Journal of Molecular Sciences, 24: 5360.
BRIEF, FA 2022, Pesticides use, pesticides trade and pesticides indicators, FAO, Rome, Italy.
Camacho-Pérez, MR, Covantes-Rosales, CE, Toledo-Ibarra, GA, Mercado-Salgado, U, Ponce-Regalado, MD, Díaz-Resendiz, KJG & Girón-Pérez, MI 2022, Organophosphorus pesticides as modulating substances of inflammation through the cholinergic pathway. International Journal of Molecular Sciences, 23:4523.
Carvalho, FP 2017, Pesticides, environment, and food safety.Food and energy security, 6: 48-60.
Celik, E, Oguzturk, H, Sahin, N, Turtay, MG, Oguz, F & Ciftci, O 2016, Protective effects of hesperidin in experimental testicular ischemia/reperfusion injury in rats’, Archives of Medical Science, 12:928–934.
Chu, Y, Li, Q, He, Y, Li, H, Wang, Q, Li, S, Wang, J, Wang, W & Ju, S 2024, Exposure to chlorpyrifos interferes with intercellular communication in cumulus-oocyte complexes during porcine oocyte maturation. Food and Chemical Toxicology, 187: 114629.
Crescenti, A, Caimari, A, Alcaide-Hidalgo, JM, Mariné-Casadó, R, Valls, RM, Companys, J, Salamanca, P, Calderón-Pérez, L, Pla-Pagà, L, Pedret, A, Delpino-Rius, A, Herrero, P, Samarra, I, Arola, L, Solà, R & Del Bas, JM 2022, Hesperidin bioavailability is increased by the presence of 2S-Diastereoisomer and Micronization-A Randomized, crossover and double-blind clinical trial. Nutrients, 14: 2481.
Díaz-Resendiz, KJG, Toledo-Ibarra, GA & Girón-Pérez, MI 2015, Modulation of immune response by organophosphorus pesticides: fishes as a potential model in immunotoxicology. Journal of Immunology Research, 2015: 213836.
Eaton, DL, Daroff, RB, Autrup, H, Bridges, J, Buffler, P, Costa, LG, Coyle, J, McKhann, G, Mobley, WC & Nadel, L 2008, Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Critical Reviews in Toxicology, 38: 1-125.
El-Wakf, AM, El-Habibi, ESM, Barakat, NM, Attia, AM, Hussein, AM & Ali, II 2018, Cardiovascular toxic effects of chlorpyrifos: a possible protective role for pomegranate extracts. Journal of Clinical Toxicology, 8.
Farahat, FM, Ellison, CA, Bonner, MR, McGarrigle, BP, Crane, AL, Fenske, RA, Lasarev, MR, Rohlman, DS, Anger, WK, Lein, PJ & Olson, JR 2011, Biomarkers of chlorpyrifos exposure and effect in Egyptian cotton field workers. Environmental Health Perspectives, 119: 801-806.
Gattuso, G, Barreca, D, Gargiulli, C, Leuzzi, U & Caristi, C 2007, Flavonoid composition of citrus juices. Molecules, 12:1641–1673.
Ibrahim, KA, Khwanes, SA, El-Desouky, MA & Elhakim, HKA 2019, Propolis relieves the cardiotoxicity of chlorpyrifos in diabetic rats via alleviations of paraoxonase-1 and xanthine oxidase genes expression.Pesticide Biochemistry and Physiology, 159: 127-135.
Imperatrice, M, Cuijpers, I, Troost, FJ & Sthijns, MM 2022, Hesperidin functions as an ergogenic aid by increasing endothelial function and decreasing exercise-induced oxidative stress and inflammation, thereby contributing to improved exercise performance. Nutrients, 14: 2955.
Kermani, M, Dowlati, M, Gholami, M, Sobhi, HR, Azari, A, Esrafili, A, Yeganeh, M & Ghaffari, HR 2021, A global systematic review, meta-analysis and health risk assessment on the quantity of Malathion, Diazinon and Chlorpyrifos in vegetables. Chemosphere, 270: 129382.
Khalaf, HA & El-Mansy, AAE-R 2019, The possible alleviating effect of saffron on chlorpyrifos experimentally induced cardiotoxicity: Histological, immunohistochemical and biochemical study. Acta Histochemica, 121: 472-483.
Kim, J, Wie, M-B, Ahn, M, Tanaka, A, Matsuda, H & Shin, T 2019, Benefits of hesperidin in central nervous system disorders: a review. Anatomy & Cell Biology, 52: 369-377.
Kwong, TC 2002, Organophosphate pesticides: biochemistry and clinical toxicology. Therapeutic Drug Monitoring, 24: 144-149.
Li, D, Huang, Q, Lu, M, Zhang, L, Yang, Z, Zong, M & Tao, L 2015, The organophosphate insecticide chlorpyrifos confers its genotoxic effects by inducing DNA damage and cell apoptosis. Chemosphere, 135: 387-393.
Li, Y, Kandhare, A, Mukherjee, A & Bodhankar, S 2019, Acute and sub-chronic oral toxicity studies of hesperidin isolated from orange peel extract in Sprague Dawley rats. Regulatory Toxicology and Pharmacology, 105: 77-85.
Massoud, A, SaadAllah, M, Dahran, NA, Nasr, NE, El-Fkharany, I, Ahmed, MS, Alsharif, KF, Elmahallawy, EK & Derbalah, A 2022, Toxicological effects of Malathion at low dose on Wister male rats with respect to biochemical and histopathological alterations. Frontiers in Environmental Science, 10: 1-11.
Mitkovska, V & Chassovnikarova, T 2020, Chlorpyrifos levels within permitted limits induce nuclear abnormalities and DNA damage in the erythrocytes of the common carp. Environmental Science and Pollution Research, 27: 7166-7176.
Nandi, NK, Vyas, A, Akhtar, MJ & Kumar, B 2022, The growing concern of chlorpyrifos exposures on human and environmental health. Pesticide Biochemistry and Physiology, 185: 105138.
Omar, AAA-H, Gad, MF, Refaie, AA, Abdelhafez, HM & Mossa, A-TH 2023, Benchmark dose approach to DNA and liver damage by Chlorpyrifos and Imidacloprid in male rats: The protective effect of a Clove-oil-based nanoemulsion loaded with pomegranate peel extract. Toxics, 11: 569.
Pallotta, MM, Barbato, V, Pinton, A, Acloque, H, Gualtieri, R, Talevi, R, Jammes, H & Capriglione, T 2019, In vitro exposure to CPF affects bovine sperm epigenetic gene methylation pattern and the ability of sperm to support fertilization and embryo development. Environmental and Molecular Mutagenesis, 60: 85-95.
Parhiz, H, Roohbakhsh, A, Soltani, F, Rezaee, R & Iranshahi, M 2015, Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.Phytotherapy Research : PTR, 29: 323-331.
Pyrzynska, K 2022, Hesperidin: A review on extraction methods, stability and biological activities. Nutrients, 14: 2387.
Rahman, N, Pervin, M, Kuramochi, M, Karim, MR, Izawa, T, Kuwamura, M & Yamate, J 2018, M1/M2-macrophage polarization-based hepatotoxicity in d-galactosamine-induced acute liver injury in rats. Toxicologic Pathology, 46: 764-776.
Rajak, P, Ganguly, A, Sarkar, S, Mandi, M, Dutta, M, Podder, S, Khatun, S & Roy, S 2021, Immunotoxic role of organophosphates: An unseen risk escalating SARS-CoV-2 pathogenicity.Food and Chemical Toxicology , 149: 112007.
Saunders, M, Magnanti, BL, Correia Carreira, S, Yang, A, Alamo-Hernández, U, Riojas-Rodriguez, H, Calamandrei, G, Koppe, JG, Krayer von Krauss, M & Keune, H 2012, Chlorpyrifos and neurodevelopmental effects: a literature review and expert elicitation on research and policy. Environmental Health, 11: 1-11.
Sharifnia, M, Eftekhari, Z & Mortazavi, P 2023, Niosomal hesperidin attenuates the M1/M2-macrophage polarization-based hepatotoxicity followed chlorpyrifos-induced toxicities in mice. Pesticide Biochemistry and Physiology, 198:105724.
Sharma, A, Kumar, V, Shahzad, B, Tanveer, M, Sidhu, GPS, Handa, N, Kohli, S, Yadav, P, Bali, A, Parihar, R, Dar, O, Singh, K, Jasrotia, S, Bakshi, PMR, Kumar, S, Bhardwaj, R & Thukral, A 2019, Worldwide pesticide usage and its impacts on ecosystem. SN Applied Sciences, 1: 1446.
Sidhu, GK, Singh, S, Kumar, V, Dhanjal, DS, Datta, S & Singh, J 2019, ‘Toxicity, monitoring and biodegradation of organophosphate pesticides: a review. Critical Reviews in Environmental Science and Technology, 49: 1135-1187.
Talebi, S, Kooshki, A, Zarein, M, Seify, M, Dolatshahi, B, Shoorei, H & Bhandari, R 2024, Protective effect of hesperidin on malathion-induced ovarian toxicity in mice: The role of miRNAs, inflammation, and apoptosis. Toxicology Reports, 12: 469-476.
Tudi, M, Daniel Ruan, H, Wang, L, Lyu, J, Sadler, R, Connell, D, Chu, C & Phung, DT 2021, Agriculture development, pesticide application and its impact on the environment. International Journal of Environmental Research and Public Health, 18: 1112.
Vahabi Barzi, N, Eftekhari, Z, Doroud, D & Eidi, A 2022, Maternal exposure during organogenesis to chlorpyrifos insecticide induce apoptosis process. The Journal of Maternal-Fetal & Neonatal Medicine, 35: 3845-3852.
Wdowiak, K, Walkowiak, J, Pietrzak, R, Bazan-Woźniak, A & Cielecka-Piontek, J 2022, Bioavailability of Hesperidin and its aglycone Hesperetin—compounds found in Citrus fruits as a parameter conditioning the pro-health potential—Mini-Review. Nutrients, 14: 2647.
Wisnujati, NS 2023, Unveiling the epoch: exploring pesticide utilization and trade trends globally and regionally from 1990 to 2020. SCIENTIA: Journal of Multi Disciplinary Science, 2: 108-121.
Wołejko, E, Łozowicka, B, Jabłońska-Trypuć, A, Pietruszyńska, M & Wydro, U 2022, Chlorpyrifos occurrence and toxicological risk assessment: a review. International Journal of Environmental Research and Public Health, 19: 12209.
Xing, H, Wang, C, Wu, H, Chen, D, Li, S & Xu, S 2015, Effects of atrazine and chlorpyrifos on DNA methylation in the brain and gonad of the common carp. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 168: 11-19.
Yang, Y, Wei, S, Zhang, B & Li, W 2021, Recent progress in environmental toxins-induced cardiotoxicity and protective potential of natural products. Frontiers in Pharmacology, 12: 699193.
Yap, KM, Sekar, M, Wu, YS, Gan, SH, Rani, NNIM, Seow, LJ, Subramaniyan, V, Fuloria, NK, Fuloria, S & Lum, PT 2021, Hesperidin and its aglycone hesperetin in breast cancer therapy: A review of recent developments and prospects. Saudi Journal of Biological Sciences, 28: 6730-6747.
Yuan, H, Ma, Q, Ye, L & Piao, G 2016, The traditional and modern medicine from natural products. Molecules, 21: 559.
Zeng, X, Du, Z, Ding, X & Jiang, W 2021, Protective effects of dietary flavonoids against pesticide-induced toxicity: A review. Trends in Food Science & Technology, 109: 271-279.
Zhong, G, Xie, Z, Cai, M, Möller, A, Sturm, R, Tang, J, Zhang, G, He, J & Ebinghaus, R 2012, Distribution and air-sea exchange of current-use pesticides (CUPs) from East Asia to the high Arctic Ocean. Environmental Science & Technology, 46: 259-267.
| ||
|
آمار تعداد مشاهده مقاله: 242 تعداد دریافت فایل اصل مقاله: 48 |
||