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Correction of liver changes caused by alcohol rates with probiotics | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 22، شماره 4، دی 2024، صفحه 993-998 اصل مقاله (816.55 K) | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.8123 | ||
| نویسندگان | ||
| Zhadyra Orynbayeva* 1؛ Zina Tungushbayeva1؛ Kundyz Nurlybayeva2؛ Fatima Abikenova3؛ Urszula Jankiewicz4؛ Ainur Seilkhan1؛ Laura Koibasova5؛ Usen Kurmanbay6 | ||
| 1Abai Kazakh National Pedagogical University, Faculty of Natural Sciences and Geography, Almaty, Kazakhstan | ||
| 2Karaganda Buketov University, Karaganda, Kazakhstan | ||
| 3Department of Physiology, NP JSC “Karaganda Medical University”, Karaganda, Kazakhstan | ||
| 4Warsaw University of Life Sciences, Biochemistry and Microbiology Department, Institute of Biology. Warsaw, Poland | ||
| 5Institute of Genetics and Physiology, MS MHES RK, Almaty, Kazakhstan | ||
| 6Department of Chemistry and Biology, Faculty of Pedagogical and Natural Sciences, Zh. Tashenev university, Shymkent, Kazakhstan | ||
| چکیده | ||
| There is evidence of the beneficial effects of probiotics in fatty liver cases. This study aims to evaluate the effects of probiotic intake on several metabolic factors in people with fatty liver. Eighty patients with fatty liver with a body mass index above 25 were divided into three groups: the control group, the alcohol group, and the probiotic group. After 45 days, fasting blood samples, physical changes, and dietary intakes were measured over the experiment. Statistical analysis was performed with SPSS software, and variance analysis was done. Significant reduction in weight (4%) and BMI (5%) was observed (p-value less than 0.001). The percent changes in weight and BMI were at a rate of 4.8% compared to the control group. The waist circumference in both groups showed a significant difference after the intervention, with the probiotic group decreasing by 8% compared to the control group. The findings showed that probiotic treatment was beneficial in reducing the severity of liver damage, most likely through increasing beneficial bacteria and reducing inflammatory responses and oxidative stress, and led to weight loss and BMI. | ||
| کلیدواژهها | ||
| Fatty Liver؛ Adipokines؛ Alcohol؛ Probiotic | ||
| مراجع | ||
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