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Innovative achievements in the detection of synaptic plasticity and oxidative stress in mice: Precision imaging, improved biosensoring, and personalized interventions for neurological disorders | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 22، شماره 3، مهر 2024، صفحه 697-713 اصل مقاله (830.04 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.7916 | ||
| نویسندگان | ||
| Roza Zhumakhanova1؛ Nazgul Zhaparkulova* 2؛ Sarzhan Sharipova3؛ Nazym Orazbayeva4؛ Banu Yeszhan5؛ Zhuldyz Zhaksybay2؛ Saniya Ossikbayeva6؛ Aigul Akhmetova2؛ Balbobek Ursheeva2 | ||
| 1Auezov South Kazakhstan State University, St. Tauke khan 5, Shymkent, Kazakhstan | ||
| 2Al-Farabi Kazakh National University, Department of Biophysics, Biomedicine and Neuroscience, 71 al-Farabi Ave, Almaty, Kazakhstan | ||
| 3Kazakh National Medical University named after S.D. Asfendiyarov, Department of Pharmaceutical and Toxicological Chemistry, Pharmacognosy and Botany, Almaty, Kazakhstan | ||
| 4Abai Kazakh National Pedagogical University, Dostyk ave.13, Almaty, Kazakhstan | ||
| 5Sports Medicine of the Kazakh Academy of Sports and Tourism, Department of Anatomy, Physiology and Medicine, Almaty, Kazakhstan | ||
| 6Specialist of Centre Molecular Genetics of the Kazakh Institute of Oncology and Radiology, Almaty, Kazakhstan | ||
| چکیده | ||
| Advancements in neuroscience have led to transformative technologies for detecting synaptic plasticity and oxidative stress, with profound implications for understanding and treating neurological disorders. This paper explores novel approaches in precision imaging, biosensoring, and personalized interventions aimed at individualized patient care, using mouse models to simulate human neurological conditions and considering the impact of environmental factors on neurological health. Innovative imaging techniques, particularly optogenetics, are revolutionizing our understanding of synaptic plasticity dynamics in mice by providing a 3-fold improvement in spatial resolution and enabling precise temporal control of synaptic activity. Such advancements are critical for investigating potential environmental influences on neural function. Furthermore, the emergence of advanced biosensors represents a groundbreaking innovation in real-time monitoring of oxidative stress biomarkers in mouse models. Nanotechnology-driven biosensor platforms offer a 10-fold increase in sensitivity and a 5-fold improvement in specificity compared to traditional assays, enabling continuous assessment of oxidative stress dynamics, which is crucial for neurodegenerative disease management, especially in environmentally stressed populations. The integration of personalized interventions guided by genetic and molecular profiling promises tailored therapeutic strategies that also account for environmental exposures. Precision medicine approaches, including closed-loop neuromodulation systems, leverage biosensor feedback to dynamically adjust interventions based on individual mouse responses and environmental conditions, optimizing treatment outcomes. In conclusion, the convergence of these innovative achievements in synaptic plasticity detection, oxidative stress imaging, and personalized interventions, with an awareness of environmental contexts, heralds a new era in neurological research and clinical practice. By harnessing cutting-edge technologies and demonstrating significant improvements over traditional methods, researchers are poised to revolutionize diagnostics and therapeutics, ultimately improving outcomes for individuals affected by neurological disorders in diverse environmental settings. | ||
| کلیدواژه‌ها | ||
| Biosensoring؛ Environmental factors؛ Neurological disorders؛ Optogenetics؛ Precision imaging؛ Synaptic lasticity | ||
| مراجع | ||
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Ahmad, A, Imran, M & Ahsan, H 2023, Biomarkers as biomedical bioindicators: approaches and techniques for the detection, analysis, and validation of novel Biomarkers of diseases. Pharmaceutics, 15(6): 1630.
Bertrand, KFB, Pascal, CDD, Désiré, DDP, Arielle, MFM, Odette, SN, Sone, M, Bertin, TA & Joseph, GF 2017, Role of aged garlic extract against radiation induced oxidative stress associated with some biochemical disorders in male albino rats. Journal of Diseases and Medicinal Plants, 13: 96-116.
Cheng, Y, Kou, W, Zhu, D, Yu, X & Zhu, Y 2022, Future directions in diagnosis, prognosis and disease monitoring of adrenocortical carcinoma: Novel non-invasive biomarkers. Frontiers in Endocrinology, 12: 811293.
Crawford, RJ, Fortin, M, Weber 2nd, KA, Smith, A & Elliott, JM 2019, Are magnetic resonance imaging technologies crucial to our understanding of spinal conditions? Journal of Orthopaedic & Sports Physical Therapy, 49: 320-329.
Darvin, P & Sasidharan Nair, V 2023, Understanding mitochondrial dynamics and metabolic plasticity in cancer stem cells: Recent advances in cancer treatment and potential therapeutic approaches. Frontiers in Oncology, 13: 1155774
Dean, DJ, Woodward, N, Walther, S, McHugo, M, Armstrong, K & Heckers, S 2020, Cognitive motor impairments and brain structure in schizophrenia spectrum disorder patients with a history of catatonia. Schizophrenia Research, 222: 335-341.
Ebrahimi, Y, AL-Baghdady, H a F A, Hameed, NM, Iswanto, A, Shnain Ali, M, Hammoodi, HA, Hashim Kzar, H, Aravindhan, S, Khodaei, SM & Alikord, M 2022, Common fatty acids and polyphenols in olive oil and its benefits to heart and human health. Caspian Journal of Environmental Sciences, 1-7.
Fredj, Z & Sawan, M 2023, Advanced nanomaterials-based electrochemical biosensors for catecholamines detection: challenges and trends. Biosensors, 13: 211.
Glasgow, SD, Ruthazer, ES & Kennedy, TE 2021, Guiding synaptic plasticity: novel roles for netrin‐1 in synaptic plasticity and memory formation in the adult brain. The Journal of Physiology, 599: 493-505.
Govindaraj, R, Agar, M, Currow, D & Luckett, T 2023, Assessing patient-reported outcomes in routine cancer clinical care using electronic administration and telehealth technologies: Realist synthesis of potential mechanisms for improving health outcomes. Journal of Medical Internet Research, 25: e48483.
Guaqueta, AMS, Hobbie, F, Oun, A, Boddeke, E, Gomez, GPC & Dolga, A 2019, Linalool attenuates cell death against oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. IBRO Reports, 6: S366.
Hameister, R, Kaur, C, Dheen, ST, Lohmann, CH & Singh, G 2020, Reactive oxygen/nitrogen species (ROS/RNS) and oxidative stress in arthroplasty. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 108: 2073-2087.
Kawashima, M, Harii, K, Horiuchi, Y, Seidman, E, Lei, X, Hopfinger, R & Lee, E 2020, Safety, efficacy, and patient satisfaction with onabotulinumtoxinA for the treatment of upper facial lines in Japanese subjects. Dermatologic Surgery, 46: 483-490.
Kilinc, D & Demir, A 2018, Spike timing precision of neuronal circuits Journal of computational neuroscience, 44, 341-362
Letellier, M & Cingolani, LA 2021, Homeostatic synaptic plasticity: From synaptic circuit assembly to neurological disorders. Frontiers Media SA. 15: 695313.
Lucendo, AJ & Molina-Infante, J 2022, Current treatment options and long-term outcomes in patients with eosinophilic esophagitis. Expert Review of Clinical Immunology, 18: 859-872.
Malenica, I, Donadon, M & Lleo, A 2020, Molecular and immunological characterization of biliary tract cancers: a paradigm shift towards a personalized medicine. Cancers, 12: 2190.
Manzari, MT, Shamay, Y, Kiguchi, H, Rosen, N, Scaltriti, M & Heller, DA 2021, Targeted drug delivery strategies for precision medicines. Nature Reviews Materials, 6: 351-370.
McCarthy, T & delBarco-Trillo, J 2020, Tardigrade abundance in relation to urbanisation and highly anthropogenic substrates. Journal of Urban Ecology, 6(1), juaa008.
Mısır, E & Akay, GG 2023, Synaptic dysfunction in schizophrenia. Synapse, 77: e22276.
Mizuta, K & Sato, M 2024, Multiphoton imaging of hippocampal neural circuits: Techniques and biological insights into region-, cell-type-, and pathway-specific functions. Neurophotonics, 11: 033406-033406.
Mochida, S 2020, Neurotransmitter release site replenishment and presynaptic plasticity. International Journal of Molecular Sciences, 22: 327.
Moore, C 2020, Medical internet of things-based healthcare systems: wearable sensor-based devices, patient-generated big data, and real-time clinical monitoring. American Journal of Medical Research, 7: 41-47.
Oyeniyi, J & Oluwaseyi, P Emerging Trends in AI-Powered Medical Imaging: Enhancing Diagnostic Accuracy and Treatment Decisions. International Journal of Enhanced Research In Science Technology & Engineering, 13: 2319-7463, DOI: 10.55948/IJERSTE.2024.0412
Shahzamani, S, Hosseini, SF, Karimi, M, Khajoei Nejad, F, Ghobadi, R, Mazaheri, Y & Parsaei, P 2023, Anticancer potential of Rhus coriaria L. (Sumac): A mini review. Caspian Journal of Environmental Sciences, 1-5.
Suhonen, R, Stolt, M & Edvardsson, D 2022, Personalized nursing and health care: advancing positive patient outcomes in complex and multilevel care environments. MDPI, 12: 1801.
Wang, W, Kiyoshi, CM, Du, Y, Taylor, A T, Sheehan, ER, Wu, X & Zhou, M 2020, TREK-1 null impairs neuronal excitability, synaptic plasticity, and cognitive function. Molecular Neurobiology, 57: 1332-1346.
Yen, C, Lin, CL & Chiang, MC 2023, Exploring the frontiers of neuroimaging: a review of recent advances in understanding brain functioning and disorders. Life, 13: 1472.
Zaidan, M, Burtin, M, Zhang, JD, Blanc, T, Barre, P, Garbay, S, Nguyen, C, Vasseur, F, Yammine, L & Germano, S 2020, Signaling pathways predisposing to chronic kidney disease progression. JCI Insight, 5(9). | ||
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