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| تعداد مقالات | 6,886 |
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Effects of hazelnut consumption on blood lipids in hyperlipidemic adults: A RCT | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 22، شماره 3، مهر 2024، صفحه 627-637 اصل مقاله (913.31 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.7849 | ||
| نویسندگان | ||
| Alma Katasheva* 1؛ Askar Kalekeshov2؛ Meruyert Parmanbekova2؛ Galiya Tatarinova3؛ Laura Koibasova4؛ Zhadyra Nauryzbayeva2؛ Zaida Rakhimova2؛ Almagul Almabekova5؛ Kuanysh Syman6 | ||
| 1Almaty Technological University, Department “Food Biotechnology,” Tole bi 100 St., Almaty, Kazakhstan | ||
| 2Kazakh National Women’s Teacher Tranıng University, Gogolya 112/1, Almaty, Kazakhstan | ||
| 3Kazakh-Russian Medical University, Department of Anatomy with Physiology Courses, Torekulova St., 13, Almaty, Kazakhstan | ||
| 4Institute of Genetics and Physiology, Al-Farabi St., 93, Almaty, Kazakhstan | ||
| 5Department of Chemistry, Kazakh National Medical University named afterS.D. Asfendiyarov, Almaty, Kazakhstan | ||
| 6Department of Biology, Faculty of Natural Sciences and Geography, Kazakh National Pedagogical University, Almaty, Kazakhstan | ||
| چکیده | ||
| Hyperlipidemia is a major risk factor for cardiovascular disease, necessitating effective dietary interventions. This randomized controlled trial (RCT) searched the impacts of hazelnut consumption on blood lipids in hyperlipidemic adults, emphasizing innovative approaches to optimize outcomes. Two hundred hyperlipidemic adults were randomized into intervention and control groups. The intervention group received tailored hazelnut doses based on body weight for 12 weeks, while the control group maintained their usual diet. Advanced lipid profiling and biomarker analyses were employed to assess hazelnut bioavailability and lipid metabolism. Hazelnut consumption led to significant improvements in lipid profiles compared to the control group. Participants receiving higher hazelnut doses demonstrated greater reductions in total cholesterol (p < 0.05) and LDL cholesterol (p < 0.01), with sustained effects observed during a 12-week follow-up. Biomarker analyses revealed enhanced bioavailability of beneficial nutrients from hazelnuts, supporting their lipid-lowering effects. This study innovatively explored hazelnut dosing based on body weight to establish a dose-response relationship. Advanced lipid profiling provided mechanistic insights into hazelnut-mediated lipid metabolism changes. Additionally, a behavioral intervention combining hazelnut consumption with dietary counseling enhanced participant engagement and adherence. Hazelnut consumption, particularly at optimized doses, demonstrates promising effects on blood lipids in hyperlipidemic adults. Our findings support the integration of hazelnuts into personalized dietary recommendations for lipid management. | ||
| کلیدواژه‌ها | ||
| Biomarker analyses؛ Hazelnut consumption؛ Hyperlipidemia؛ Lipid profiles؛ Randomized controlled trial | ||
| مراجع | ||
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