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Effects of coenzyme Q10 and N-acetylcysteine on the expression of apoptotic biomarkers and histopathological findings in the permethrin-induced hepatotoxicity in rats | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 22، شماره 4، دی 2024، صفحه 841-847 اصل مقاله (1.07 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2023.7254 | ||
| نویسندگان | ||
| Nima Asadi1؛ Alireza Shahriary2؛ MohammadMahdi Jafarzadeh3؛ Maryam Ghorbani* 4؛ Ehsan Yavari5 | ||
| 11Students' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 2Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 3Department of Biology, Faculty of Basic Sciences, Rasht Branch, Islamic Azad University, Rasht, Iran | ||
| 44Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| 5Department of Pharmacology and Toxicology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Permethrin (PMT) is a synthetic pyrethroid insecticide widely applied in the agriculture and animal husbandry industry. The current study focused on the evaluation of the oxidative damage and apoptosis induced by PMT, as well as the protective role of coenzyme Q10 and N-acetylcysteine (NAC) against PMT toxicity in the liver of male rats. In this study, rats were divided in four groups, including G1 (control), G2 (PMT), G3 (NAC + PMT), and G4 (Q10 + PMT). Levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. RT-PCR was adopted to study the expression of Bax, Bcl2, p53, Caspases-3 and -9 genes. PMT exposure significantly decreased FRAP value, whereas increased MDA content in the liver tissue (p < 0.001). While Bcl2 was downregulated (5.31-fold), permethrin increased the expression of Bax (4.84-fold), p53 (4.67-fold), Caspases-3 (6.21-fold) and Caspases -9 (6.36-fold) genes in exposed group (p<0.001). Both Q10 and NAC significantly improved FRAP values and decreased MDA level. Unlike the apoptotic genes, Bcl2 expression was significantly reversed after NAC and Q10 therapy (p < 0.001). In conclusion, PMT exposure induced oxidative stress and liver cells’ apoptosis. Q10 and NAC can mitigate toxic effects of PMT and consequently protect liver damage. | ||
| کلیدواژه‌ها | ||
| Permethrin؛ Q10؛ NAC؛ Oxidative stress؛ Apoptosis | ||
| مراجع | ||
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