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ramezani, N., dezhan, M., Mortazavi, S., Baghaee Borzabadi, M., ahadi, Z., Khalili, S. (2023). The effect of high intensity interval training on Insulin resistance and serum levels and gene expression of irisin in subcutaneous adipose tissue of type 2 diabetic rats. Aquatic Physiology and Biotechnology, 13(1), 87-99. doi: 10.22124/jme.2023.23732.239
nasrin ramezani; mahshid dezhan; Seyed Amirhossein Mortazavi; Mozhgan Baghaee Borzabadi; zahra ahadi; Saeideh Sadat Khalili. "The effect of high intensity interval training on Insulin resistance and serum levels and gene expression of irisin in subcutaneous adipose tissue of type 2 diabetic rats". Aquatic Physiology and Biotechnology, 13, 1, 2023, 87-99. doi: 10.22124/jme.2023.23732.239
ramezani, N., dezhan, M., Mortazavi, S., Baghaee Borzabadi, M., ahadi, Z., Khalili, S. (2023). 'The effect of high intensity interval training on Insulin resistance and serum levels and gene expression of irisin in subcutaneous adipose tissue of type 2 diabetic rats', Aquatic Physiology and Biotechnology, 13(1), pp. 87-99. doi: 10.22124/jme.2023.23732.239
ramezani, N., dezhan, M., Mortazavi, S., Baghaee Borzabadi, M., ahadi, Z., Khalili, S. The effect of high intensity interval training on Insulin resistance and serum levels and gene expression of irisin in subcutaneous adipose tissue of type 2 diabetic rats. Aquatic Physiology and Biotechnology, 2023; 13(1): 87-99. doi: 10.22124/jme.2023.23732.239

The effect of high intensity interval training on Insulin resistance and serum levels and gene expression of irisin in subcutaneous adipose tissue of type 2 diabetic rats

سوخت و ساز و فعالیت ورزشی
Volume 13, Issue 1, April 2023, Pages 87-99    PDF (796.74 K)
Document Type: Research Paper I Open Access I Released under (CC BY-NC) license
DOI: 10.22124/jme.2023.23732.239
Authors
nasrin ramezani* 1; mahshid dezhan2; Seyed Amirhossein Mortazavi2; Mozhgan Baghaee Borzabadi2; zahra ahadi2; Saeideh Sadat Khalili3
1عضو همتراز هیات علمی دانشگاه الزهرا (س)
2-
3any department
Abstract
Diabetes is the most common endocrine disease in the world, and various methods such as exercise and physical activity are used to treat it. the aim of this study was to determine the effect of high-intensity interval training on serum glucose, insulin ,irisin and its gene expression in subcutaneous adipose tissue in type 2 diabetic rats. For this study, 20 males of the wistar male rat (8-10 weeks with a weight of 250-270 g) were selected and randomly divided into two groups of diabetic control and diabetic exercise. After the introductory course, the experimental group performed high-intensity exercise for 4 weeks, 5 days a week for 10 minutes as 1-minute interval at a speed of 30-40 meters per second. 48 hours after the last training session and after 12 hours of fasting, glucose and insulin values serum values and expression of irisin gene were measured in subcutaneous adipose tissue. Data were analyzed using independent t-test. The results showed that 4 weeks of high-intensity interval training reduced serum glucose levels and insulin resistance index (p = 0.001), significantly increased serum values (p = 0.001) and expressed irisin gene (P = 0.004) in subcutaneous adipose tissue was controlled in the exercise group compared to the group.

High-intensity interval training can reduce serum glucose levels and insulin resistance index in type 2 diabetic rats and increase serum levels and irisin gene expression in adipose tissue. it is suggested to use this type of exercises to reduce the problems caused by type 2 diabetes.
Keywords
High-intensity interval training; type 2 diabetes; irisin; subcutaneous adipose tissue
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