تاثیر تمرین مقاومتی تناوبی با شدت‌های مختلف بر سطوح سرمی اینترلوکین-6 ، عامل نکروز تومور-آلفا و نوروگلین-4 مردان چاق

1. World Health Organization.Prevention and control of cardiovascular diseases. Alexandria Egypt, WHO-Emro 2014.
2. Tahergorabi Z KM. The relationship between inflammatory markers, angiogenesis, and obesity. ARYA Atheroscler 2013;9(4):247-53.
3. Saltiel AR OJ. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017;127(1):1-4.
4. M B. Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance? Clin Sci (Lond). 2016;130(18):1603-14.
5. Bennett G SKJ, DeFuria J, Wang J, Wu D, Burkly L C, et al. Deletion of TNF‐like weak inducer of apoptosis (TWEAK) protects mice from adipose and systemic impacts of severe obesity. Silver Spring. 2014;22(6):1485-94.
6. Abd El-Kader S GA, Salah El-Den A.. Impact of moderate versus mild aerobic exercise training on inflammatory cytokines in obese type 2 diabetic patients: a randomized clinical trial. Afr Health Sci. 2013;13(4):857-63.
7. Eizadi M, Haji Rasouli, M., Khorshidi, D. The Effect of 3 Months of Aerobic Training on TNF-α and Insulin Resistance in Obese Men with Type 2 Diabetes. Journal of Sport Biosciences. 2019;11(3):253-69.
8. Tutunchi, H., Ostadrahimi, A., Hosseinzadeh-Attar, M. J., Miryan, M., Mobasseri, M., and Ebrahimi- Mameghani, M. (2020). A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances.  Rev.21:e12952. doi: 10.1111/obr.12952
9. Pfeifer, A. (2015). Nrg4: an endocrine link between brown adipose tissue and liver. Cell Metab.21, 13–14. doi: 10.1016/j.cmet.2014.12.008Nugroho DB, Ikeda, K., Kajimoto, K., Hirata, K. I., and Emoto, N. Activation of neuregulin-4 in adipocytes improves metabolic health by enhancing adipose tissue angiogenesis. Biochem Biophys Res. 2018b;504(71):427–33.
10. Zahra Ghorbani Ganjeh MG, Hojatolah Nikbakht. Effect of Resistance Training with Different Intensities on Adiponectin and Lipid Profiles in Overweight Women. J Rehab Med. 2020;8(4):47-55.
11. Rostamizadeh M. EA, Rahmani Nia F. Effects of Aerobic and Resistance Exercises onAnthropometric Indices and Osteocalcin, Leptin, Adiponectin Levels in Overweight Men. J Arak Uni Med Sci. 2019;22(1):85-95.
12. Tomeleri CM RA, Souza MF, Schiavoni D, Schoenfeld BJ, Venturini D, et al. Resistance training improves inflammatory level, lipid and glycemic profiles in obese older women: A randomized controlled trial. Exp Gerontol, 2016,84(10)7-80..
13. Moro Tatiana MG, Bianco Antonino, Bolzetta Francesco and et al.. Effects of 6 Weeks of Traditional Resistance Training or High Intensity Interval Resistance Training on or High Intensity Interval Resistance Training on Body Composition, Aerobic Power and Strength in Healthy Young Subjects: A Randomized Parallel Trial. International Journal of Environmental Research and Public Health. 2020;17(4):1-15.
14. Jones SB, Thomas GA, Hesselsweet SD, Alvarez-Reeves M, Yu H, Irwin ML. Effect of exercise on markers of inflammation in breast cancer survivors: the Yale exercise and survivorship study. Cancer Prev Res (Phila). 2013 Feb;6(2):109-18. doi: 10.1158/1940-6207.CAPR-12-0278.
15. Sardeli AV TC, Cyrino ES, Fernhall B, Cavaglieri CR, Chacon-Mikahil MPT. Effect of resistance training on inflammatory markers of older adults: A meta-analysis. Exp Gerontol 2018;111(23):188- 96.
16. Ho SS, Dhaliwal, S., Hills, A. P., & Pal, S. . Effects of Chronic Exercise Training on Inflammatory Markers in Australian Overweight and Obese Individuals in a Randomized Controlled Trial. Inflammation. 2012;36(3):625–32.
17. Ferreira FC MA, Nicioli C, Nunes JED, Shiguemoto GE, Prestes J, et al. Circuit resistance training in sedentary women: body composition and serum cytokine levels. Appl Physiol Nutr Metab. 2009;35(8):163–71.
18. Cantó C CA, Barnes BR, Glund S, Suárez E, Ryder JW, et al. Neuregulins mediate calcium-induced glucose transport during muscle contraction. journal of Biological Chemistry. 2006;281(31):21690-7.
19. WANG Q-a CM-x, TIAN Z-j. Effects of Resistance Training on NRG1 Express of Heart and Skeletal Muscle in Different Gender Rats with Myocardial Journal of Beijing Sport University. 2014;11(12):81-91.
20. Hayashino Y JJ, Hirata T, Fukumori N, Nakamura F, Fukuhara S, et al. Effects of exercise on C-reactive protein, inflammatory cytokine and adipokine in patients with type 2 diabetes: a meta-analysis of randomized controlled trials. . Metabolism. 2014;63(3):431-40.
21. Ablove T BN, Leadley S, Shelton J, Ablove R. Body mass index continues to accurately predict percent body fat as women age despite changes in muscle mass and height. Menopause. 2015;22(7):727–30.
22. Bastard J P, Jardel C, Bruckert E, Blondy P, Capeau J, Laville M. Journal of Clinical Endocrinology & Metabolism. Vol. 85. The Endocrine Society; 2000. Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss; pp. 3338–3342.
23. Candrawati Susiana, Huriyati Emy, Sofro Zaenal Muttaqien, Rujito Lantip, Hidayah Chaerunnisa, Hayuningtyas Dyah Asri, Fahmi Muhammad Sidqi. Annals of Applied Sport Science. Vol. 10. CMV Verlag; 2022. The Effect of UCP2 45bp Insersi/Delesi Genetic Variation on the Body Composition of Woman with Obesity in Continuous Training and High-Intensity Interval Training: A Randomized Controlled Trial Study; pp. 0–0.
24. Cabral-Santos Carolina, Castrillón Carlos I M, Miranda Rodolfo A T, Monteiro Paula A, Inoue Daniela S, Campos Eduardo Z, Hofmann Peter, Lira Fábio S. Frontiers in Physiology. 7. Frontiers Media SA; 2016. Inflammatory Cytokines and BDNF Response to High-Intensity Intermittent Exercise: Effect the Exercise Volume; pp. 509–509.
25. Cullen Tom, Thomas Andrew W, Webb Richard, Hughes Michael G. Applied Physiology, Nutrition, and Metabolism. Vol. 41. Canadian Science Publishing; 2016. Interleukin-6 and associated cytokine responses to an acute bout of high-intensity interval exercise: the effect of exercise intensity and volume; pp. 803–808. 
26. Bolboli L, Ghafari G, Rajabi A. Effect of omega-3 consumption and participate in aerobic exercise on sICAM-1 and pro-inflammatory cytokines in obese elderly women. Sport Physiology. 2014;6(21):79–94.
27. Neto Rosa, Lira J C, Oyama F S, Zanchi L M, Yamashita N E, Batista A S, M L, Jr. Exhaustive exercise causes an anti-inflammatory effect in skeletal muscle and a pro-inflammatory effect in adipose tissue in rats. Eur J Appl Physiol. 2009;106(5):697–704.
28. Febbraio Mark A, Steensberg Adam, Starkie Rebecca L, Mcconell Glenn K, Kingwell Bronwyn A. 7. Vol. 52. Elsevier BV; 2003. Skeletal muscle interleukin-6 and tumor necrosis factor-α release in healthy subjects and patients with type 2 diabetes at rest and during exercise; pp. 939–944. 
29. Wagenmakers Anton JM, Pedersen Bente Klarlund. Essays in biochemistry. 42. Portland Press; 2006. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control; pp. 105–117.
30. Tehrani Maryam MN, Rouhollah Ranjbar Comparison the Effect of Acute Resistance Exercise with Different Volume on Plasma Interleukin-6 Response. Journal of Applied Health Studies in Sport Physiology. 2019;6(2):79-85.
31. Loyd C MI, Haas M, Balusu S, Krishna R, Itoh N, et al. Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding. Journal of Applied Physiology. 2016;121(3):687-98.
32. Azizbeigi K AM, Atashak S, Stannard SR. Effect of Moderate and High Resistance Training Intensity on Indices of Inflammatory and Oxidative Stress. Res Sports Med 2015;23(1):73-87.
33. Ghafari M BE, Heidari A. Impact of High-Intensity Interval Training and Concurrent Strength-Endurance Training on the Levels of Some Adipokines Associated with Insulin Resistance in Women with Diabetes Mellitus. hrjbaq. 2017;2(3):193-206. [ in Persian ]
34. García-Unciti M IM, Idoate F, Gorostiaga E, Grijalba A, Ortega-Delgado F, et al. Weight-loss diet alone or combined with progressive resistance training induces changes in association between the cardiometabolic risk profile and abdominal fat depots. Annals of Nutrition and Metabolism. 2012;61(4):296-304.
35. Akbarpour M. The Effect of Resistance Training on Serum Levels of Adipokine and Inflammatory Markers of Cardiovascular Disease in Obese Men. Qom Univ Med Sci J 2013; 7 (3) :1-10 .
36. Zehsaz F FN, Mirheidari L. The effect of aerobic training on CXL5, tumor necrosis factor α and insulin resistance index (HOMA-IR) in sedentary obese women. Central-European Journal of Immunology 2014;39(3);71-365.
37. Balducci S ZS, Nicolucci A, Fernando F, Cavallo S, Cardelli Pة. Anti-Inflammatory Effect Of Exercise Training In Subjects With Type 2 Diabetes And The Metabolic Syndrome Is Dependent On Exercise Modalities And Independent Of Weight Loss. Nutr Metab Cardiovasc Dis 2010;20(8):608-17.
38. Zha JM DW, Zhu T, Xie Y, Yu J, Liu J, et al. Comparison of gene transcription between subcutaneous and visceral adipose tissue in Chinese adults. Endocr J. 2009;56(8):935-44.
39. Lira FS RJ, dos Santos RV, Venancio DP, Carnier J, de Lima Sanches P, et al. Visceral fat decreased by longterm interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor–α and negatively with adiponectin levels in obese adolescents. Metabolism. 2011;60(3):359-65.
40. Golbidi S LI. Exercise induced adipokine changes and the metabolic syndrome. J Diabetes Res. 2014;65(9):230-40.
41. Ma MG, and D. Liu. Preventing high fat dietinduced obesity and improving insulin sensitivity through neuregulin 4 gene transfe. Scientific Reports. 2016;6(1):262-70.
42. Ghanbari-Niaki A, rezaei nezhad, N., Alizadeh, R. The effect of different Intensities of circuit resistance training on plasma neuregulin and leptin concentrations in young men. Journal of Sport and Exercise Physiology. 2018;11(2):1-12.
43. Ennequin G BN, Caillaud K, Chavanelle V, Gerbaix M, Metz L, et al. Exercise training and return to a well‐balanced diet activate the neuregulin 1/ErbB pathway in skeletal muscle ofobese rats. The Journal of physiology. 2015;593(12):2665-77.
44. Chen, Z., Wang, G.-X., Ma, S. L., Jung, D. Y., Ha, H., Altamimi, T., et al. (2017). Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders.  Metab.6, 863–872. doi: 10.1016/j.molmet.2017.03.016
45. Ma, Y., Gao, M., and Liu, D. (2016). Preventing high fat diet-induced obesity and improving insulin sensitivity through neuregulin 4 gene transfer.  Rep.6:26242. doi: 10.1038/srep26242
46. Lebrasseur NK CG, Miller TA, Fielding RA, Sawyer DB. Regulation of neuregulin/ErbB signaling by contractile activity in skeletal muscle. American Journal of Physiology-Cell Physiology. 2003;284(5): C1149-C55.
47. Vahid Asaad KA, Nikoo Khosravi, Nahid Hagh Nazari. Effect of Exercise Training on Omentin-1 and Vaspin: Comparison of Continuous Endurance, Circuit Resistance, and High Intensity Interval Trainings in Obese Young Men. J Rehab Med. 2020;8(4):103-12.

Blundell JE, et al. Appetite control and energy balance: impact of exercise. Obesity reviews. 2015;16(7):67–76.