پیوندهای مفید
آمار
| تعداد نشریات | 31 |
| تعداد شماره‌ها | 659 |
| تعداد مقالات | 6,128 |
| تعداد مشاهده مقاله | 7,634,832 |
| تعداد دریافت فایل اصل مقاله | 5,854,939 |
Dracocephalum kotschyi: Inhibition of critical enzyme relevant to type-2 diabetes, essential oil composition, bactericidal and anti-oxidant activity | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 27 بهمن 1401 اصل مقاله (1.2 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2023.6256 | ||
| نویسندگان | ||
| Mehri Kazempour؛ S. Shirin Shahangian* ؛ Reyhaneh Sariri | ||
| Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran | ||
| چکیده | ||
| Dracocephalum kotschyi, an endemic medicinal plant in Iran, has long been used in folk medicine to treat various disorders. This study aimed to determine the phytochemical composition and biological activities of various extracts of leaves and flowers of D. kotschyi. Different solvent extracts (aqueous solution of acetone, methanol, ethanol, and a mixture of acetone and methanol) of D. kotschyi were screened for anti-amylase activity, antioxidant potential, and antibacterial efficiency. Antioxidant effects were elucidated by the methods such as DPPH and FRAP. The inhibitory potential of the extracts against amylase, a key enzyme involved in diabetes, was investigated by the Bernfeld method. The total phenolic, flavonoid, and anthocyanin contents of these extracts were also calculated. Disc diffusion, MIC, and MBC methods were applied to analyze the antibacterial efficiency of the extracts. GC-MS analysis of the essential oil was performed. Additionally, the HPLC method was used for the identification and quantification of caffeic acid. Based on antioxidant assays, the acetonic extract showed the highest antioxidant ability, due to its highest total antioxidant content. Also, the acetonic extract strongly inhibited α-amylase activity. Various extracts of D. kotschyi displayed inhibitory effects against both Gram-positive and Gram-negative bacteria. Analyzing the essential oils of the leaves and flowers of D. kotschyi by GC-MS led to identifying 6 and 19 compounds, respectively. These results suggest that D. kotschyi can be considered a promising source of natural antioxidant, antimicrobial, and anti-amylase agents for managing oxidative damage, as well as pharmaceutical and food purposes. | ||
| کلیدواژه‌ها | ||
| Dracocephalum kotschyi؛ Chemical composition؛ Anti-amylase؛ Antioxidant؛ Antibacterial | ||
| مراجع | ||
|
Ahumada Santos, YP et al. 2013, Chemical characterization, antioxidant and antibacterial activities of six Agave species from Sinaloa, Mexico. Industrial crops and products. Elsevier, 49: 143-149.
Ali, H, Houghton, PJ & Soumyanath, A 2006, α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Journal of Ethnopharmacology. Elsevier, 107: 449-455.
Anyanwu, MU & Okoye, RC 2017, Antimicrobial activity of Nigerian medicinal plants. Journal of Intercultural Ethnopharmacology. SAGEYA, 6: 240.
Aryaeian, N, Sedehi, SK & Arablou, T 2017, Polyphenols and their effects on diabetes management: A review. Medical Journal of the Islamic Republic of Iran. Iran University of Medical Sciences. 3: 134.
Ashrafi, B et al. 2017, Investigation on chemical composition, antimicrobial, antioxidant, and cytotoxic properties of essential oil from Dracocephalum kotschyi Boiss. African Journal of Traditional, Complementary and Alternative Medicines. African Ethnomedicines Network (Nigeria), 14: 209-217.
Bernfeld, P 1955, Amylases, alpha and beta, Methods in Enzymology I, 1: 149-158. http://dx.doi.org/10.1016/ 0076-6879(55)01021-5.
Bjelakovic, G, Nikolova, D & Gluud, C 2014, Antioxidant supplements and mortality, Current Opinion in Clinical Nutrition & Metabolic Care. LWW, 17: 40-44.
Boeing, JS et al. 2014, Evaluation of solvent effect on the extraction of phenolic compounds and antioxidant capacities from the berries: application of principal component analysis. Chemistry Central Journal, Nature Publishing Group, 8: 48.
Boulekbache Makhlouf, L et al. 2013, Effect of solvents extraction on phenolic content and antioxidant activity of the byproduct of eggplant. Industrial Crops and Products. Elsevier B.V., 49: 668-674. DOI: 10.1016/j.indcrop.2013.06.009.
Chalamaiah, M, Hemalatha, R & Jyothirmayi, T 2012, Fish protein hydrolysates: proximate composition, amino acid composition, antioxidant activities and applications: a review. Food Chemistry, Elsevier, 135: 3020–3038.
Chang, CC, Yang, MH & Wen, HM 2002, Estimation of Total Flavonoid Content in Propolis by Two Complementary Colorimetric Methods. Journal of Food and Drug Analysis, 10: 178–182. DOI: N/A.
Dai, J & Mumper, RJ 2010, Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, Molecular Diversity Preservation International, 15: 7313-7352.
Do, QD et al. 2014, Effect of extraction solvent on total phenol content, total flavonoid content, and antioxidant activity of Limnophila aromatica. Journal of Food and Drug Analysis. Elsevier, 22: 296-302.
Espíndola, KMM et al. 2019, Chemical and Pharmacological Aspects of caffeic acid and its activity in hepatocarcinoma. Frontiers in Oncology, Frontiers Media SA, 9.
Fallah, S et al. 2018, Chemical compositions of essential oil and antioxidant activity of dragonhead (Dracocephalum moldavica) in sole crop and dragonhead-soybean (Glycine max) intercropping system under organic manure and chemical fertilizers. Industrial Crops and Products, Elsevier, 115: 158-165.
Farvin, KHS et al. 2014, Antioxidant activity of cod (Gadus morhua) protein hydrolysates: In vitro assays and evaluation in 5% fish oil-in-water emulsion. Food Chemistry, Elsevier, 149: 326-334.
Girgih, AT et al. 2015, Evaluation of the in vitro antioxidant properties of a cod (Gadus morhua) protein hydrolysate and peptide fractions. Food Chemistry, Elsevier, 173: 652-659.
Golshani, S et al. 2004, Antinociceptive effects of the essential oil of Dracocephalum kotschyi in the mouse writhing test. Journal of Pharmaceutical Sciences, 7: 76-79.
Heydari, P et al. 2019, Medicinal Properties and Active Constituents of Dracocephalum kotschyi and Its Significance in Iran: A Systematic Review. Evidence-Based Complementary and Alternative Medicine. Hindawi.
Humeera, N et al. 2013, Antimicrobial and antioxidant activities of alcoholic extracts of Rumex dentatus L. Microbial Pathogenesis. Elsevier, 57: 17-20.
Jahaniani, F et al. 2005, Xanthomicrol is the main cytotoxic component of Dracocephalum kotschyii and a potential anti-cancer agent. Phytochemistry, Elsevier, 66: 1581-1592.
Javidnia, K et al. 2005, Composition of the essential oil of Dracocephalum kotschyi Boiss. from Iran. Journal of Essential Oil Research. Taylor & Francis, 17: 481-482.
Jiang, Q 2014, Natural forms of vitamin E: metabolism, antioxidant, and anti-inflammatory activities and their role in disease prevention and therapy. Free Radical Biology and Medicine. Elsevier, 72: 76-90.
Kchaou, W et al. 2013, Effects of extraction solvents on phenolic contents and antioxidant activities of Tunisian date varieties (Phoenix dactylifera L.). Industrial Crops and Products. Elsevier B.V., 45: 262-269, DOI: 10.1016/j.indcrop.2012.12.028.
Khademian Amiri, SA, Aghajanzadeh, T, Jafari, N & Mahmoudi, M 2022, Antioxidative compounds, enzymes activity and nutrient elements in Stachys byzantina are altered by climate conditions not by soil parameters. Caspian Journal of Environmental Sciences, 20: 1099-1115.
Khodaei, M et al. 2018, Chemical analysis and anti-bacterial effect of essential oils from three different species of Dracocephalum in Iran. American Journal of Essential Oils and Natural Products, 6: 31-34.
Kumar, BR 2017, Application of HPLC and ESI-MS techniques in the analysis of phenolic acids and flavonoids from green leafy vegetables (GLVs). Journal of Pharmaceutical Analysis, Elsevier, 7: 349-364.
Lee, SH. et al. 2011, Acetylcholinesterase inhibitory and antioxidant properties of Rhododendron yedoense var. poukhanense Bark. Journal of Medicinal Plants Research, Citeseer, 5: 248-254.
Lila, MA 2004, Anthocyanins and human health: an in vitro investigative approach. BioMed Research International, Hindawi, 5: 306-313.
Liu, SC et al. 2009, Antioxidant properties of various solvent extracts from lychee (Litchi chinenesis Sonn.) flowers. Food Chemistry, Elsevier, 114: 577-581.
Meda, A et al. 2005, Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activity. Food Chemistry, 91: 571-577, DOI: 10.1016/j. foodchem.2004.10.006.
Metrouh Amir, H, Duarte, CMM & Maiza, F 2015, Solvent effect on total phenolic contents, antioxidant, and antibacterial activities of Matricaria pubescens. Industrial Crops and Products. Elsevier B.V., 67: 249-256. DOI: 10.1016/j.indcrop.2015.01.049.
Miliauskas, G, Venskutonis, PR & Van Beek, A 2004, Screening of radical scavenging activity of some medicinal and aromatic plant extracts. Food Chemistry, 85: 231–237, DOI: 10.1016/j.foodchem.2003.05.007.
Mita, S et al. 1997, Mutants of Arabidopsis thaliana with pleiotropic effects on the expression of the gene for beta-amylase and on the accumulation of anthocyanin that are inducible by sugars. Plant Journal, 11: 841-851, DOI: DOI 10.1046/j.1365-313X.1997.11040841.x.
Moon, J & Shibamoto, T 2009, Antioxidant assays for plant and food components antioxidant assays. Plant and Food Components, 57: 1655-1666, DOI: 10.1021/jf803537k.
Naczk, M & Shahidi, F 2006, Phenolics in cereals, fruits and vegetables: Occurrence, extraction and analysis. Journal of Pharmaceutical and Biomedical Analysis, 41: 1523-1542, DOI: 10.1016/j.jpba.2006.04.002.
Noipa, T et al. 2011, New approach for evaluation of the antioxidant capacity based on scavenging DPPH free radical in micelle systems, Food Research International. Elsevier Ltd, 44: 798-806, DOI: 10.1016/j. foodres.2011.01.034.
Obaid, RF, Kadhim Hindi, NK, Kadhum, SA, Jafaar Alwaeli, LA & Jalil, AT 2022, Antibacterial activity, anti-adherence and anti-biofilm activities of plants extracts against Aggregatibacter actinomycetemcomitans: An in vitro study in Hilla City, Iraq. Caspian Journal of Environmental Sciences, 20: 367-372.
Panche, AN, Diwan, AD & Chandra, SR 2016, Flavonoids: An overview. Journal of Nutritional Science, Cambridge University Press, Vol. 5, p.e47.
Pokorný, J & Korczak, J 2001, Preparation of natural antioxidants. Antioxidants in Food, pp. 311-327, DOI: 10.1016/9781855736160.4.311.
Rebey, IB et al. 2012, Effects of extraction solvents and provenances on phenolic contents and antioxidant activities of cumin (Cuminum cyminum L.) seeds. Food and Bioprocess Technology. Springer, 5: 2827–2836.
Rice Evans, C, Miller, N & Paganga, G 1997, Antioxidant properties of phenolic compounds. Trends in Plant Science. Elsevier, 2: 152-159.
Ruiz Cruz, S et al. 2017, Flavonoids: Important bio-compounds in food. Flavonoids-From Biosynthesis to Human Health. IntechOpen, 18 p.
Saha, S & Verma, R 2012, Inhibitory potential of traditional herbs on α-amylase activity. Pharmaceutical Biology. Taylor & Francis, 50: 326-331.
Sarmadi, BH & Ismail, A 2010, Antioxidative peptides from food proteins: a review. Peptides, Elsevier, 31: 1949-1956.
Scalbert, A 1991, Antimicrobial properties of tannins. Phytochemistry, Elsevier, 30: 3875-3883.
Shin, SA et al. 2018, Structure-based classification and anti-cancer effects of plant metabolites, International Journal of Molecular Sciences. Multidisciplinary Digital Publishing Institute, 19: 2651.
Sulaiman, SF et al. 2011, Effect of solvents in extracting polyphenols and antioxidants of selected raw vegetables. Journal of Food Composition and Analysis, Elsevier, 24: 506-515.
Turkmen, N, Sari, F & Velioglu, YS 2006, Effects of extraction solvents on concentration and antioxidant activity of black and black mate tea polyphenols determined by ferrous tartrate and Folin–Ciocalteu methods. Food Chemistry, Elsevier, 99: 835-841.
Vadivelan, R, Krishnan, RG & Kannan, R 2019, Antidiabetic potential of Asparagus racemosus Willd leaf extracts through inhibition of α-amylase and α-glucosidase. Journal of Traditional and Complementary Medicine, Elsevier, 9: 1-4.
Wijekoon, MMJO, Bhat, R & Karim, AA 2011, Effect of extraction solvents on the phenolic compounds and antioxidant activities of bunga kantan (Etlingera elatior Jack.) inflorescence. Journal of Food Composition and Analysis. Elsevier Inc., 24: 615-619, DOI: 10.1016/j.jfca.2010.09.018.
Zahrae Redouan, F, Benitez, G, Aboubakr, B, Bakkouri Bassma, E, Maria Picone, R, Crisafulli, A, Ben Driss, A, Kadiri, M, Molero Messa, J & Merzouki, A 2020, The status and perception of medicinal plants by local population of Talassemtane National Park (Northern Morocco). Caspian Journal of Environmental Sciences, 18: 131-147
Zhao, H et al. 2006, Effects of extraction solvent mixtures on antioxidant activity evaluation and their extraction capacity and selectivity for free phenolic compounds in barley (Hordeum vulgare L.). Journal of Agricultural and Food Chemistry, 54: 7277-7286, DOI: 10.1021/jf061087w.
Zhu, X et al. 2009, Primary dysmenorrhoea: a comparative study on Australian and Chinese women. Complementary Therapies in Medicine, Elsevier, 17: 155-160.
Zieliński, H & Kozłowska, H 2000, Antioxidant activity and total phenolics in selected cereal grains and their different morphological fractions. Journal of Agricultural and Food Chemistry, ACS Publications, 48: 2008-2016.
Zuo, Y, Chen, H & Deng, Y 2002, Simultaneous determination of catechins, caffeine and gallic acids in green, oolong, black and pu-erh teas using HPLC with a photodiode array detector. Talanta, 57: 307-316. DOI: 10.1016/S0039-9140(02)00030-9. | ||
|
آمار تعداد مشاهده مقاله: 115 تعداد دریافت فایل اصل مقاله: 188 |
||