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Inhibition activity of aluminium oxide nanoparticles for herpes simplex type 1 | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 21، شماره 1، فروردین 2023، صفحه 125-133 اصل مقاله (1.04 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2023.6203 | ||
| نویسندگان | ||
| Abbas. K. Almansorri1؛ Hider. M. H. Al-Shirifi2؛ Sharafaldin Al-Musawi* 3؛ Bara B Ahmed1 | ||
| 1Faculty of Biotechnology, Al-Qasim Green University, Babylon, Iraq | ||
| 2Al-Qasim Green University, Environmental Sciences College, Environmental Health Department | ||
| 3College of Food Sciences, Al-Qasim Green University, Babylon Province, Iraq | ||
| چکیده | ||
| Several studies have shown that herpes simplex type 1) HSV-1 (is one of the viruses resistant to medications, so potential antiherpetic agents need to be evaluated. This study aimed to evaluate the impact of aluminium oxide Nanoparticles (Al2O3-NPs) on the HSV-1 infection. Characterization of Al2O3-NPs were performed using field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and high-resolution transmission electron microscopy (HRTEM). The MTT test was used to investigate the toxicity action of Al2O3-NPs on viable cells. Quantitative Real-Time PCR (qRT-PCR) and TCID50 assays were used to achieve antiherpetic performance of Al2O3-NPs. Indirect immunofluorescence assay (IFA) was performed to determine the inhibitory impact of Al2O3-NPs on viral antigen expression, and Acyclovir was utilized as a standard agent in all tests. HSV-1 was subjected to Al2O3-NPs at the maximum non-toxic concentration (100 μg mL-1) led to a decrease of 0.1, 0.7, 1.8, and 2.5 log10 TCID50 in the infectious titer relative to virus control (P < 0.0001). This concentration of Al2O3-NPs was correlated with 16.9%, 47.1 %, 61.2 %, 72.5 % and 74.6 % inhibition rate, calculated on the basis of HSV-1 viral load compared to virus control. Our results have shown that Al2O3-NPs exhibit a robust antiviral activity against HSV-1. This function demonstrates excellent potential for using Al2O3-NP in topical formulations for treating orolabial or genital herpetic lesions. | ||
| کلیدواژه‌ها | ||
| Herpes Simplex Virus type 1؛ Aluminium oxide nanoparticles؛ Real-Time PCR؛ Antiviral Activity؛ Indirect immunofluorescence assay | ||
| مراجع | ||
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