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The role of mast cells, C-fibers, and cholinergic transmission in the reduction of tracheal muscle and mronchi of sensitized animal | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 18، شماره 5، اسفند 2020، صفحه 495-502 اصل مقاله (562.6 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2020.4477 | ||
| نویسندگان | ||
| V.M. Kirilina* ؛ L.E. Blazhevich؛ O.E. Smirnova | ||
| Department of Life Safety and Health-saving Technologies, Federal State Budgetary Educational Institution of Higher Education «Petrozavodsk State University, Petrozavodsk, The Republic of Karelia, the city of Petrozavodsk, Russia | ||
| چکیده | ||
| The article considers the role of stabilization of mast cell membranes, blockade of neuromuscular transmission and inactivation of C-fibers in the contractile activity of smooth muscles of the trachea and bronchi of sensitized rats. The studies were conducted on isolated preparations using electrical stimulation of postganglionic nerves (frequency - 30 stim/s, duration - 0.5 ms, amplitude - 20 V, duration of stimulation - 10 s). The study used cromolyn sodium, atropine, and capsaicin. As a result of the experiments, it was found that the leading role in the contraction of the muscles of the trachea and bronchi of a sensitized rat belongs to mast cells. However, the maximum effect of normalization of smooth muscle contraction can be achieved only in the case of a complex effect - blockade of neuromuscular transmission, stabilization of mast cell membranes, and inactivation of C-fibers. | ||
| کلیدواژه‌ها | ||
| Romolyn sodium؛ Atropine؛ Capsaicin؛ Acetylcholine receptor blockade؛ Electrical stimulation؛ Postganglionic nerves | ||
| مراجع | ||
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