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اثر هشت هفته تمرین مقاومتی شدید و متوسط بر سطوح استراحتی مایوستاتین و IGF-1 سرم رتهای سالمند | ||
سوخت و ساز و فعالیت ورزشی | ||
مقاله 1، دوره 8، شماره 1، تیر 1397، صفحه 1-14 اصل مقاله (948.33 K) | ||
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC) license I Open Access I | ||
شناسه دیجیتال (DOI): 10.22124/jme.2018.3560 | ||
نویسندگان | ||
زهره شانظری1؛ محمد فرامرزی* 2؛ ابراهیم بنی طالبی3؛ روح الله همتی3 | ||
1دانشجوی دکتری فیزیولوژی ورزشی | ||
2دانشیار دانشگاه شهرکرد | ||
3استادیار دانشگاه شهرکرد | ||
چکیده | ||
هدف: یکی از اختلالات مهم و شایع در افراد سالمند، آتروفی عضلانی وابسته به سن یا سارکوپنیاست. سارکوپنیا با کاهش چشمگیر در قدرت و حجم توده عضلانی همراه است. هدف از این مطالعه بررسی تاثیر دو نوع تمرین مقاومتی شدید و متوسط بر سطوح سرمی مایوستاتین و IGF-1 سرم رتهای سالمند بود. روششناسی: سی سر رت نر نژاد ویستار مسن (23 هفته) به صورت تصادفی در دو گروه تمرینی و گروه کنترل شامل گروه تمرین مقاومتی با شدت متوسط (9=n)، تمرین مقاومتی با شدت بالا (8=n)، و گروه کنترل (8=n) قرار گرفتند. تمرین مقاومتی شامل 8 هفته تمرین مقاومتی نردبان با شدت زیاد ( 80% MVCC) و شدت متوسط (60% MVCC ) و 5 روز در هفته بود. بعد از دوره تمرین غلظت سرمی IGF-1و مایوستاتین به روش الایزا اندازهگیری شد. یافتهها: غلظت مایوستاتین در گروه مقاومتی شدید (12/43±50/916) و مقاومتی متوسط (87/36±78/958) کاهش و غلظت IGF-1 در گروه مقاومتی شدید (49/15±27/156) و مقاومتی متوسط (42/7±77/141) افزایش معنیداری داشت (05/0P<). بین تاثیر تمرین مقاومتی شدید و متوسط بر سطوح IGF-1 تفاوت معنیدار (009/0p = ) بود. با این حال، در مورد مایوستاتین تفاوت معنیداری مشاهده نشد. نتیجهگیری: به نظر میرسد تمرین مقاومتی با شدتهای متوسط و بالا میتواند باعث تغییر سطوح استراحتی عوامل مرتبط با آتروفی عضلانی در رتهای سالمند شود. با این حال، بررسی بیشتر در نمونههای انسانی ضروری به نظر میرسد. | ||
کلیدواژهها | ||
مایوستاتین؛ IGF-1؛ رتهای سالمند | ||
مراجع | ||
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