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Influence of butylcaptax and Dropp on the phospholipid composition and lipid peroxidation (LPO) in the liver mitochondria and microsomes of pregnant rats and their embryos | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 24، شماره 2، تیر 2026، صفحه 305-318 اصل مقاله (978.67 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2026.9616 | ||
| نویسندگان | ||
| Dilfuza Tuychiyeva* 1؛ Parida Mirkhamidova2؛ Gulnara Shakhmurova2؛ Rano Alimova3؛ Gafurzhon Mukhamedov4؛ Oybek Sattarov5؛ Nurxon Moydinova6؛ Mavjuda Rakhmatullayeva7؛ Bahtigul Azimova7؛ Mukhayyo Kattaboyeva8 | ||
| 1Department of Biological Chemistry and Pharmacy, Andijan Branch of Kokand University, Andijan | ||
| 2Department of Biology, Faculty of Natural Sciences, National Pedagogical University of Uzbekistan named after Nizami, Tashkent City, Uzbekistan | ||
| 3Department of Biochemistry and Physiology, Tashkent State Agrarian University, Tashkent State Agrarian University, Tashkent region, Uzbekistan | ||
| 4Rector of Chirchik State Pedagogical University, Tashkent, Uzbekistan | ||
| 5Department of Faculty and Hospital Surgery No.1, Tashkent State Medical University, Tashkent, Uzbekistan | ||
| 6Department of Microbiology, Immunology and Virology, Andijan Branch of Kokand University, Andijan, Uzbekistan | ||
| 7Department of Inorganic, physical and colloidal chemistry, Tashkent Pharmaceutical Institute, Tashkent, Uzbekistan | ||
| 8Department of basic medical sciences Faculty of Medicine, Termez University of Economics and Service, Termez, Uzbekistan | ||
| چکیده | ||
| This study investigates the effects of the defoliants butylcaptax and Dropp on the phospholipid composition and lipid peroxidation (LPO) in the liver mitochondria and microsomes of pregnant rats and their embryos. Experiments were conducted on Wistar rats exposed to 1/10 of the LD50 dose on gestation days 3, 13, and 19. The results demonstrated a decrease in phosphatidylethanolamine and total phospholipid content, along with an increase in phosphatidic acid, lysophospholipids, and the cholesterol/phospholipid ratio. A significant enhancement of both enzymatic and non-enzymatic LPO was observed in the mitochondria and microsomes, with more pronounced effects following butylcaptax exposure. Although embryonic tissues exhibited less marked alterations, similar trends were observed. The findings indicate the activation of lipid peroxidation processes and the disruption of membrane structures, which may contribute to embryotoxic effects. | ||
| کلیدواژهها | ||
| Butylcaptax؛ Dropp؛ Phospholipids؛ Mitochondria؛ Microsomes؛ Liver؛ Pregnant rats؛ Embryos؛ Lipid peroxidation؛ Embryotoxicity | ||
| مراجع | ||
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