Current state and prospects of using medicinal plants growing in the Zailiysky and Zhetysu Alatau, Kazakhstan

Abdreshov, SN, Demchenko, GA, Atanbaeva, GK, Mankibaeva, SA, Akhmetbaeva, NA, Kozhaniyazova, UN, Nauryzbai, UB 2021, Condition of adrenergic innervation apparatus of the thyroid gland, blood and lymph vessels, and lymph nodes during correction of hypothyrosis. Bulletin of Experimental Biology and Medicine, 171(2): 281-285, https://doi.org/10.1007/s10517-021-05212-5.

Abdreshov, S, Kozhaniyazova, U, Bgatova, N, Demchenko, G, Shynybekova, SH & Oxikbayev, B 2023, Morphofunctional state and microstructure of regional lymph nodes in experimental hypothyroidism and under correction. Archiv EuroMedica, 1(6): e1, htpp://dx.doi. org/10.35630/2023/13/6.601.

Abdulkhaleq, LA, Assi, MA, Abdullah, R, Zamri-Saad, M, Taufiq-Yap, Y. H, Hezmee, MNM. 2018, The crucial roles of inflammatory mediators in inflammation: A review. Veterinary World, 11(5): 627–635, https://doi.org/10.14202/vetworld.2018.627-635.

Aidarbayeva, D, Ahmet, A, Sitpayeva, G, Baiseitova, A & Jenis, J 2024, Ajania fastigiata in Zhetysu Alatau: Distribution, morphological characterization, phytochemical profiles, and optimization of extraction of bioactive constituents. Journal of Applied Research on Medicinal and Aromatic Plants, 40:100540. DOI 10.1016/j.jarmap.2024.100540.

Аidarkhanova, GS, Novak, AP, Imasheva, BS & Tashev, A 2019, Assessment of the resources of medicinal herbs in the forests of the Kazakhstan part of Altai and their ecological condition. Bulletin of the Karaganda University, Series «Biology, Medicine, Geography», 3(95): 72-79.

Aidosova, AA, Akhtayeva, NZ, Osmonali, BB & Tileubai BS 2021, Morphological and ecological-geographical features of the Ammodendron Argenteum. Journal Pharmaceutical production technology, 2(235): 73-76.

Akhmetov, AA, Mukhitdinov, N & Ydyrys, A 2015, Anatomical indicators of the leaf structure of Ferulail. iensis, growing in the eastern part of Zailiyskiy Alatau (Big Boguty Mountains). Pakistan Journal of Botany, 47(2): 511-515.

Altammar KA 2025, Unveiling Therapeutic Powers of Indigenous Flora: Antimicrobial, Antioxidant, and Anticancer Properties of Horwoodia dicksoniae. Pharmaceuticals (Basel, Switzerland), 18(5): 765. https://doi.org/10.3390/ph18050765.

Ametov, AA, Kurbatova, NV, Mukhitdinov, NM, Abidkulova, KT & Aytmukamet, N 2014, Floristic description of areal and stocks raw materials of Polygonum undulatum Murr. growing in natural boundary Uytas (Trans-ili Alatau). KazNU Blletin, Biology Series, 2(61): 3-8.

Asnaashari, S, Dastmalchi, S & Javadzadeh, Y 2018, Gastroprotective effects of herbal medicines (roots). International Journal of Food Properties, 21(1): 902–920, https://doi.org/10.1080/10942912.2018.1473876.

Azhikhanova, Z, Duru, ME, Megbenu, HK, Kucukaydin, S, Tas-Kucukaydin, M, Baisalova, G, Shaimardan, M, Seiilgazy, M, Adekenov, S, Nuraje, N & Özler, MA 2024, Phytochemical study of Achillea setacea Waldst. et Kit. with anticholinesterase, antidiabetic, anti-urease, and anti-tyrosinase activities. Engineered Science, 31: 1256, https://doi.org/10.30919/es1256.

Bai, R, Yao, Ch, Zhong, Zh, Ge, J, Bai, Z, Ye, X, Xie, T & Xie, Y  2021, Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation. European Journal of Medicinal Chemistry, 213: 113165, DOI: 10.1016/j.ejmech.2021.113165.

Balkybek, Y, Tynybekov, B, Kulymbet, K, Kurmanbay U, Umirbayeva Z, Nurakyn Z, Myltykbayeva A, Ydyrys, A & Toktar, M 2025, Study of soil cover of  Veronica spuria L. populations in Ile Alatau mountains, Kazakhstan. Eqa, 66: 99-106, DOI: 10.6092/issn.2281-4485/20806. 

Chan, HC & Ng, SC 2017, Emerging biologics in inflammatory bowel disease. Journal of Gastroenterology, 52(2): 141–150. https://doi.org/10.1007/s00535-016-1283-0.

Chen, L, Deng, H, Cui, H, Fang, J, Zuo, Z, Deng, J, Li, Y, Wang, X & Zhao, L 2017, Inflammatory responses and inflammation-associated diseases in organs.  Oncotarget,  9(6): 7204–7218, https://doi.org/ 10.18632/oncotarget.23208.

Demchenko, GA, Nurmakhanova, BA, Abdreshov, SN, Koibasova, LU, Zhunussova, GS, Imankulova, SK 2023, Phytocorrection of Age-Related Changes in the Composition of Blood Plasma, Lymph, and Interstitial Fluid. Bulletin of Experimental Biology and Medicine, 175: 785–790, https://doi.org/10.1007/s10517-023-05947-3.

Dimitrova, V & Tashev A 2019, Medical plants on the territory of Petrohan Training and Experimental Forest Range, Bulgaria. Agriculturae Conspectus Scientificus. 84 (1): 37-46.

Domitrović, R & Potočnjak, I 2016, A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives. Archives of Toxicology. 90: 39-79, DOI: 10.1007/s00204-015-1580-z.

El-Saadony, MT, Saad, AM, Mohammed, DM, Korma, SA, Alshahrani, MY, Ahmed, AE, Ibrahim, EH, Salem, HM, Alkafaas, SS, Saif, AM, Elkafas, SS, Fahmy, MA, Abd El-Mageed, TA, Abady, MM, Assal, HY, El-Tarabily, MK, Mathew, BT, AbuQamar, SF, El-Tarabily, KA & Ibrahim, SA 2025, Medicinal plants: Bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review. Frontiers in Immunology, 16: 1491777, https://doi.org/10.3389/fimmu.2025.1491777.

Feng, X, Cao, S, Qiu, F & Zhang, B 2020, Traditional application and modern pharmacological research of Artemisia annua L. Pharmacology & Therapeutics, 216: 107650, DOI: 10.1016/j.pharmthera.2020.107650.

Ginwala, R, Bhavsar, R,Chigbu, DGI, Jain, P & Khan, ZK 2019, Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin. Antioxidants, 8: 35, https://doi.org/10.3390/antiox8020035.

Gorchakov, V, Abdreshov, S, Gorchakova, O, Nikolaychuk, K, Demchenko, G & Bekeneva, M 2022, Phytocorrection of the rate of aging of the intestinal region lymph node. IEEE International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON), pp. 270-273. DOI: 10.1109/SIBIRCON56155. 2022.10017057.

Ivashchenko AA, Mukhitdinov N, Abidkulova KT, Ametov A, Tashev A, Ydyrys A 2021, Floristic analysis of plant communities with the participation of a narrow tien shan endemic, Taraxacum kok-saghyz Rodin., For.Ideas, 27: 195-209, DOI: 2021/6191-1629758540.

Jain, D, Uniyal, N, Mitra, D & Janmeda, P 2020e, Traditional resources and use of aromatic and ethno- medicinal plants in Uttarakhand: Compliment of nature. International Journal of Herbal Medicine. 8(5): 88-95.

Julián-Flores, A, Aguilar-Zárate, P, Michel, MR, Sepúlveda-Torre, L, Torres-León, C, Aguilar, CN, Chávez-González, ML 2025, Exploring the therapeutic potential of medicinal plants in the context of gastrointestinal health: A review. Plants 14: 642, https://doi.org/10.3390/plants14050642.

Kadyrbay, A, Ibragimova, LN, Iwan, M, Ludwiczuk, A, Biernasiuk, A, Sakipova, ZB, Świątek, Ł, Salwa, K, Korga-Plewko, A, Zhaparkulova, KA, Bekezhanova, TS, Józefczyk, A, Szymańska, J, Malm, A 2025, Essential Oil from the Aerial Parts of Artemisia serotine Bunge (Winter Wormwood) Growing in Kazakhstan—Phytochemical Profile and Bioactivity. Molecules, 30(14): 2956, https://doi.org/10.3390/molecules30142956.

Karaubayeva, AA, Bekezhanova, T, Zhaparkulova, K, Susniak, K, Sobczynski, J, Kazimierczak, P, Przekora, A, Skalicka-Wozniak, K, Kulinowski, Ł, Glowniak-Lipa, A, Sakipova, ZB, Korona-Głowniak, I. 2024, Antimicrobial Mixture Based on Micronized Kaolinite and Ziziphora Essential Oil as a Promising Formulation for the Management of Infected Wounds. International Journal of Molecular Sciences, 25(23): 13192, https://doi.org/10.3390/ijms252313192.

Keleke, A, Maciejewska-Turska, M, Kasela, M, Baj, T, Ibragimova, L, Sakipova, Z, Sermukhamedova, O & Ludwiczuk, A 2025, Phytochemical Composition and Antimicrobial and Antioxidant Activity of Hedysarum semenowii (Fabaceae). Molecules, 30(23): 4503. https://doi.org/10.3390/molecules30234503.

Kobylina, TN, Tynybekov, BM, Nurmakhanova, AS, Satybaldieva, GK, Sadyrova, GA, Kirbasova, EA, Kulymbet, KK 2024, Sedum hybridum found in the Ili Alatau and sedum Ewersii ledeb current soil status of populations. Bulletin of the Treasury. Ecological Series, 79(2):100-109, DOI: 10.26577/EJE. 2024.v79. i2-09.

Kozhaniyazova, UN, Abdreshov, SN, Demchenko, GA, Bgatova, NP, Shynybekova, ShS 2023, New composition for correction of thyroid structures in experimental hypothyroidism. Bulletin of Karaganda University, Series «Biology, Medicine, Geography», 1(109): 143-150, DOI 10.31489/2023BMG1/143-150.

Kukenov, MK 1996, Medicinal plants in Kazakhstan and their use. edited by M K, Kukenov, Almaty, 344 p.

Kuntubek, GN, Kasela, M, Kozhanova, KK, Kukula-Koch, W, Świątek, Ł, Salwa, K, Okińczyc, P, Józefczyk, A, Widelski, J, Kadyrbayeva, GM, Mukhamedsadykova, AZ, Sakipova, ZB, & Malm, A 2025, Unraveling the chemical composition and biological activity of Geum aleppicum Jacq.: Insights from plants collected in Kazakhstan. Molecules, 30(19): 3888, https://doi.org/10.3390/molecules30193888.

Kurdyukov, EE, Pleshakova, DA, Glebova, NN, Neklyudova, VA, Vodopyanova, OA, Garanina, EO 2023, Flavonoids: Classification, biological properties, and prospects for use in medicine. International Research Journal, 11: 137, DOI: 10.23670/IRJ.2023.137.143.

Mironeasa, S, Ungureanu-Iuga, M 2024, Plants, Lichens, Fungi and Algae Ingredients for Nutrition and Health. Applied Science, 14: 2800, https://doi.org/10.3390/app14072800.

Mukta, G, Naresh, S, Monica, G, Reena, G, Kalvatala S, & Bhupinder, K 2021, Herbal bioactives in treatment of inflammation: An overview. South African Journal of Botany, Volume 143, Pages 205-225, https://doi.org/10.1016/j.sajb.2021.07.027.

Nurlybayeva, K, Bekturova, A, Kali, A, Nurkenova, A, Abikenova, F, Amanbay, B, Amantayeva, A & Mukasheva, G 2024, Antioxidant potential and phytochemical analysis of medicinal plants used for livestock treatment in Kazakhstan. Caspian Journal of Environmental Sciences, 22(3): 653-662. DOI: 10.22124/cjes.2024.7899.

Özek, G, Chidibayeva,  Ametov, A, Nurmahanova, A & Özek, T 2022, Chemical composition of flower volatiles and seeds fatty acids of Rosa iliensis Chrshan, an endemic species from Kazakhstan. Records of Natural Products, 16(3): 225–235.

Popkov, NS, Zamyslova, VD, Povydysh, MN 2025, Xanthium strumarium L.: Chemical components and biological activity (review). Drug Development and Registration. 14(3): 60–70, https://doi.org/10.33380/2305-2066-2025-14-3-2024.

Radovanović, K, Gavarić, N & Aćimović, M 2023, Anti-inflammatory properties of plants from Serbian traditional medicine. Life 13: 874, https://doi.org/10.3390/life13040874.

Rani, J, Dhull, SB, Rose, PK & Kidwai, MK 2024, Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. Phytomedicine, 122: 155142, https://doi.org/10.1016/ j.phymed.2023.155142.

Razzak, KSB, Jain, D, Hossain, MN & Bushra, A 2020, Plant edible vaccines: a natural way of vaccination (Let the Food be the Medicine). Vigyan Varta, 1 (5): 21-24.

Sami, A, Usama, M, Saeed, MM & Akram, M 2021, Medicinal plants with non-steroidal anti-inflammatory-like activity: A review. Mediterr. Journal of Pharmaceutical Sciences, 1(3): 25-32, DOI: https://doi.org/10.5281/zenodo.5534605.

Seilkhan, AS, Kudrina, NO, Cherepkova, NV, Kulmanov TE, Kurmanbayeva MS, Inelova, ZA, Shalgimbayeva, SM 2019, Anatomical and morphological structure of Peganum harmala of Almaty region and its therapeutic properties. Pakistan Journal of Botany.  51(2): 649–655, DOI: 10.30848/PJB2019-2(30).

Singh, R 2015, Medicinal plants: A review. Special Issue: Medicinal Plants. Journal of Plant Sciences, 3(1-1): 50-55.

Sinitsyn, GS New Medicinal Plants of Kazakhstan: A Monograph. Alma-Ata: Nauka, 1982. 128 p.

Slusarczyk, J, Adamska, E & Czerwik-Marcinkowska, J 2021, Fungi and algae as sources of medicinal and other biologically active compounds: A review. Nutrients, 13: 3178, https://doi.org/ 10.3390/nu13093178.

Šmejkal, K, Malaník, M, Zhaparkulova, K, Sakipova, Z, Ibragimova, L, Ibadullaeva, G & Žemlička, M 2016, Kazakh Ziziphora species as sources of bioactive substances. Molecules, 21(7): 826, https://doi.org/10.3390/molecules21070826.

Taldybay, A, Aidarbayeva, D, Kurmantayeva, A, Mussaev, K, Amanbekova, D & Joltukova B 2024, Medicinal plants in the flora of Zhetysu Alatau, Zhetysu Region, Kazakhstan. Caspian Journal of Environmental Sciences, 22(3): 567-579, DOI: 10.22124/CJES.2024.7831.

Tasneem, S, Liu, B, Li, B, Choudhary, MI, Wang, W 2019, Molecular pharmacology of inflammation: Medicinal plants as anti-inflammatory agents. Pharmacological Research, 139: 126–140, https://doi.org/10.1016/ j.phrs.2018.11.001.

Thatoi, HN & Dutta, SK 2009, Antibacterial activity and phytochemical screening of leaf and bark extracts of Vitex Negundo l. from Similipal Biosphere Reserve, Orissa. Journal of Medicinal Plants Research, 3 (4): 294-300, DOI: 10.5897/JMPR.9000120.

Tleuberlina O, Mamurova A, Iskakova ZH, Aibuldinov Y, Kolpek A, Kopishev Y, Satbaeva G, Mukazhanova ZH, Kurmanbayeva M 2023, Evaluation of the Capparis herbacea Willd's chemistry, antioxidant and cytotoxic activity. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 22(4):261-272. DOI: 10.2174/01187152302816 97231115074426.

Ydyrys, A, Molsadykkyzy, M, Syraiyl, S, Kidirbayeva KH, Raimbekova B, Barun S, Aralbaeva, A, Atanbaeva, G 2025, Ecological and phytochemical composition of Gnaphalium kasachstanicum Kirp. & Kuprian. SABRAO Journal of Breeding and Genetics, 57(2):792-803, doi.10.54910/sabrao2025.57.2.35.

Zhangabylov, NS, Aksartov, R, Gulyaev, AE, Gorbacheva, LB & Adekenov, SM 2005, Pharmacokinetics of the lactone Arglabin and its hydrochloride dimethylamino derivative. Russian Biotherapeutic Journal. 2(4): 24-28.

Zheng, MK, Shih, DQ, Chen, GC 2017, Insights on the use of biosimilars in the treatment of inflammatory bowel disease. World journal of Gastroenterology, 23(11): 1932–1943, https://doi.org/10.3748/wjg.v23.i11.1932.

Zhu, MZ, Yang, MF, Song, Y, Xu, HM, Xu, J, Yue, NN, Zhang, Y, Tian, CM, Shi, RY, Liang, YJ, Yao, J, Wang, LS, Nie, YQ & Li, DF 2023, Exploring the efficacy of herbal medicinal products as oral therapy for inflammatory bowel disease. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 165: 115266, https://doi.org/10.1016/j.biopha.2023.115266.

Zhumagul, М, Rašeta, M, Mišković, J, Myrzagaliyeva AB, Kurmanbayeva M, Gafforov Yu, Kubentayev SA, Kobylina T, Shaikhymbekova, R, Kusmangazinov, A 2024, Pharmacological evaluation of Rhodiola Rosea L. extract from the kazakh ecosystem: Implications for obesity management in male rats. Farmacia, 72(1): 104–115, DOI: 10.31925/farmacia.2024.1.10.

Zhumaliyeva, GT, Makashev, EK, Zhussupova, AI, Abdreshov, SN, Demchenko, GA 2020, Estimation of efficiency of use of dairy products enriched with enter sorbent dietary fibers on immunophysiological indicators of the rat organism. Journal of Pharmacy and Nutrition Sciences, 10(3): 92-100, DOI: 10.26577/ijbch.2020.v13.i1.12.

Zhurinov, M, Berillo, D, Bazhykova, KB, Rakhimov, KD, Bekezhanova, T 2023, An estimation of the antiviral activity and toxicity of biologically active substances obtained from the raw materials of Artemisia cina Berg in vitro and in vivo. Molecules, 28(14): 5413, https://doi.org/10.3390/molecules28145413

Zhusupova, GE, Shalakhmetova, TM, Murzakhmetova, MK, Gadetskaya, AV, Zhusupova, AI 2013, Antioxidant activity of some preparations, obtained on the basis of kazakhstani plants. 2013, Electronic Journal: Novosibirsk State Pedagogical University Bulletin, 5:(15): 43-64.

Zili, Lin, Huiyi WU, Yiming FU, Shixue Dai, 2019, Application of herbaceous medications for inflammatory bowel disease as a complementary and alternative therapy, Inflammatory Bowel Diseases, 25 (12): 1886–1895, https://doi.org/10.1093/ibd/izz190.