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Abdirassilova, Aigul, Aikimbaiyev, Alim, Yessimseit, Duman, Rysbekova, Altyn, Abdeliyev, Beck, Agzam, Sanzhar, Sairambekova, Galiya, Shaki, Nurbol, Muchtarov, Ruslan, Maksatkysy, Ayaulym, Rametov, Nurkuisa, Abdel, Ziyat, Mussagalieva, Raikhan. (1404). Genetic variability of Yersinia pestis in natural foci of the Caspian Region of Kazakhstan (1967–2021). فیزیولوژی و بیوتکنولوژی آبزیان, (), 1-13. doi: 10.22124/cjes.2025.9314
Aigul Abdirassilova; Alim Aikimbaiyev; Duman Yessimseit; Altyn Rysbekova; Beck Abdeliyev; Sanzhar Agzam; Galiya Sairambekova; Nurbol Shaki; Ruslan Muchtarov; Ayaulym Maksatkysy; Nurkuisa Rametov; Ziyat Abdel; Raikhan Mussagalieva. "Genetic variability of Yersinia pestis in natural foci of the Caspian Region of Kazakhstan (1967–2021)". فیزیولوژی و بیوتکنولوژی آبزیان, , , 1404, 1-13. doi: 10.22124/cjes.2025.9314
Abdirassilova, Aigul, Aikimbaiyev, Alim, Yessimseit, Duman, Rysbekova, Altyn, Abdeliyev, Beck, Agzam, Sanzhar, Sairambekova, Galiya, Shaki, Nurbol, Muchtarov, Ruslan, Maksatkysy, Ayaulym, Rametov, Nurkuisa, Abdel, Ziyat, Mussagalieva, Raikhan. (1404). 'Genetic variability of Yersinia pestis in natural foci of the Caspian Region of Kazakhstan (1967–2021)', فیزیولوژی و بیوتکنولوژی آبزیان, (), pp. 1-13. doi: 10.22124/cjes.2025.9314
Abdirassilova, Aigul, Aikimbaiyev, Alim, Yessimseit, Duman, Rysbekova, Altyn, Abdeliyev, Beck, Agzam, Sanzhar, Sairambekova, Galiya, Shaki, Nurbol, Muchtarov, Ruslan, Maksatkysy, Ayaulym, Rametov, Nurkuisa, Abdel, Ziyat, Mussagalieva, Raikhan. Genetic variability of Yersinia pestis in natural foci of the Caspian Region of Kazakhstan (1967–2021). فیزیولوژی و بیوتکنولوژی آبزیان, 1404; (): 1-13. doi: 10.22124/cjes.2025.9314

Genetic variability of Yersinia pestis in natural foci of the Caspian Region of Kazakhstan (1967–2021)

Caspian Journal of Environmental Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 05 دی 1404
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22124/cjes.2025.9314
نویسندگان
Aigul Abdirassilova1؛ Alim Aikimbaiyev1؛ Duman Yessimseit1؛ Altyn Rysbekova1؛ Beck Abdeliyev1؛ Sanzhar Agzam1؛ Galiya Sairambekova1؛ Nurbol Shaki1؛ Ruslan Muchtarov2؛ Ayaulym Maksatkysy1؛ Nurkuisa Rametov3؛ Ziyat Abdel1؛ Raikhan Mussagalieva* 1
1Masgut Aikimbayev’s National Scientific Center Especially Dangerous Infections of the National Holding “QazBioPharm” of the Ministry of Health of the Republic of Kazakhstan, 14 Zhakhanger St., Almaty 050054, Republic of Kazakhstan
2RSI “Mangistau Anti-plague Station” CSEC MH RK (Republic of Kazakhstan, Aktau c., 3B microdistrict 41/1)
3Tecton Analytics, R&D, Astana, Kazakhstan
چکیده
This study presents a comprehensive analysis of epizootological and epidemiological monitoring of natural plague foci in the Caspian region of the Republic of Kazakhstan. The spatio-temporal characteristics of the Volga-Ural, Ural-Emba, Pre-Ustyurt, and Manghystau plague foci are examined, including their biocenotic specificity, the composition of primary and secondary hosts, and the spectrum of pathogen vectors. The study included 28 Yersinia pestis isolates collected between 1967 and 2021 and preserved in the National Collection of Microorganisms of the NSCEDI. Their phenotypic properties, phage susceptibility, molecular-genetic identification, and comparative analysis by MLVA-25, SNP-typing, and whole-genome sequencing were assessed. The results demonstrated that most strains belong to the Medievalis biovar, while unique genetic features were identified, including the presence of the pCKF plasmid in eight isolates from all four foci of the region. Obtained data confirm the persistence of plague epizootic activity in the region and reveal its genetic variability, underscoring the need for regular monitoring and using modern molecular epidemiology methods.
کلیدواژه‌ها
Yersinia pestis؛ Plague foci؛ Caspian region؛ Kazakhstan؛ Genetic variability؛ Molecular Epidemiology؛ Medievalis biovar
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تعداد مشاهده مقاله: 24


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