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Azimova, Sanavar, Makhmudov, Farrukh, Amanova, Sholpan, Altynbayeva, Gulnara, Tattibayeva, Damira, Konarbayeva, Zulfiya, Toktamyssova, Aiman, Abdreshov, Serik, Tautayeva, Assel. (1404). Evaluating detoxification properties of pumpkin pectin and pectin-enriched foods via bioassay. فیزیولوژی و بیوتکنولوژی آبزیان, (), 1-11. doi: 10.22124/cjes.2025.9145
Sanavar Azimova; Farrukh Makhmudov; Sholpan Amanova; Gulnara Altynbayeva; Damira Tattibayeva; Zulfiya Konarbayeva; Aiman Toktamyssova; Serik Abdreshov; Assel Tautayeva. "Evaluating detoxification properties of pumpkin pectin and pectin-enriched foods via bioassay". فیزیولوژی و بیوتکنولوژی آبزیان, , , 1404, 1-11. doi: 10.22124/cjes.2025.9145
Azimova, Sanavar, Makhmudov, Farrukh, Amanova, Sholpan, Altynbayeva, Gulnara, Tattibayeva, Damira, Konarbayeva, Zulfiya, Toktamyssova, Aiman, Abdreshov, Serik, Tautayeva, Assel. (1404). 'Evaluating detoxification properties of pumpkin pectin and pectin-enriched foods via bioassay', فیزیولوژی و بیوتکنولوژی آبزیان, (), pp. 1-11. doi: 10.22124/cjes.2025.9145
Azimova, Sanavar, Makhmudov, Farrukh, Amanova, Sholpan, Altynbayeva, Gulnara, Tattibayeva, Damira, Konarbayeva, Zulfiya, Toktamyssova, Aiman, Abdreshov, Serik, Tautayeva, Assel. Evaluating detoxification properties of pumpkin pectin and pectin-enriched foods via bioassay. فیزیولوژی و بیوتکنولوژی آبزیان, 1404; (): 1-11. doi: 10.22124/cjes.2025.9145

Evaluating detoxification properties of pumpkin pectin and pectin-enriched foods via bioassay

Caspian Journal of Environmental Sciences
مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 23 مهر 1404
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22124/cjes.2025.9145
نویسندگان
Sanavar Azimova1؛ Farrukh Makhmudov* 1؛ Sholpan Amanova1؛ Gulnara Altynbayeva2؛ Damira Tattibayeva1؛ Zulfiya Konarbayeva* 3؛ Aiman Toktamyssova4؛ Serik Abdreshov5؛ Assel Tautayeva6
1Almaty Technological University, Tole bi 100, Almaty, Kazakhstan
2Higher School of Electric Power Engineering and Information Systems, Rudny Industrial University, 50 Let Oktyabrya 38, Rudny, Kazakhstan
3M. Auezov South Kazakhstan University, Tauke Khan Avenue 5, Shymkent, Kazakhstan
4Kazakh-Russian Medical University, Avenue Al-Farabi 93Г/5, Almaty, Kazakhstan
5Laboratory of Physiology Lymphatic System, Institute of Genetics and Physiology, Committee of Science, Ministry of Science and Higher Education of the Republic of Kazakhstan, 93 Al-Farabi Avenue, Almaty 050060, Kazakhstan
6International Engineering Technological University, Tole bi 109, Almaty, Kazakhstan
چکیده
Heavy metal pollution, particularly lead and cadmium, poses significant health risks due to bioaccumulation and multi-organ damage. This study investigates the detoxification potential of pumpkin pectin and pectin-rich products in laboratory rats (Rattus norvegicus). Male rats (230 ± 20 g) were chronically intoxicated with lead nitrate (2.0 mg/kg) or cadmium chloride (2.08 mg/kg) over three months. Correctors, including pumpkin pectin (0.06 g/day), pectin-enriched bread (0.5%), and confiture (1.0%), were administered orally. Haematological and biochemical blood parameters were assessed using a Hitachi spectrophotometer and a Mindray BC-3000 analyzer. Heavy metal accumulation reduced total protein (91-95% of control) and haemoglobin, and increased urea. Pumpkin pectin correction restored these parameters, with better outcomes in lead-induced rats than in cadmium-induced rats. Pectin-rich products showed moderate improvements. These findings demonstrate that pumpkin pectin serves as an effective natural chelator, mitigating the toxic effects of heavy metals. Its use is recommended for therapeutic and preventive purposes in populations exposed to chronic heavy metal pollution in industrial regions.
کلیدواژه‌ها
Cadmium؛ Detoxification؛ Heavy metals؛ Lead؛ Pectin؛ Pumpkin
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