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Impact of air pollution on the estrogen and progesterone receptors in the uterus and ovary of Wistar rat | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 25 شهریور 1404 اصل مقاله (593.8 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2025.9056 | ||
| نویسندگان | ||
| Nazli Yazdani Karganrud1؛ Pejman Mortazavi2؛ Saeed Motasaddi Zarandi3؛ Akram Eidi4 | ||
| 1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 3Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran. | ||
| 4Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Air pollution has become a significant global health concern. Exposure to PM2.5, particles with a diameter of less than or equal to 2.5 μm, has been linked to certain diseases, including female reproductive disorders. Several molecular mechanisms in the female reproductive system may be affected by PM2.5 exposure. The present study investigated the effect of PM2.5 exposure on the expression of ESR-1 and PGR steroid hormone receptors in uterine and ovarian tissues of rats as an air pollution model. Twenty-four female Wistar rats were prepared for PM2.5 exposure for three months. Exposure was conducted for five hours per day, and four days in week. Three groups were defined, including 'Group A' with exposure to PM2.5 plus gaseous pollutants, 'Group B' with exposure to gaseous pollutants only, and 'Group C' as a control group with clean standard air. Uterus and ovary tissues were removed after the scarification of the rats, and the mRNA level was examined for ESR-1 and PGR using quantitative Real-Time PCR. Findings showed significant overexpression of ESR-1 and PGR genes in exposure groups (A and B) in comparison with the control group (C). Significant up-regulation of ESR-1 and PGR genes in the uterus of group A was detected compared to group B. Results showed that PM2.5 exposure may cause upregulation of the female sex hormone receptors. It seems that PM2.5 exposure could potentially lead to several diseases related to the female reproductive system. | ||
| کلیدواژه‌ها | ||
| PM2.5 exposure؛ ESR-1؛ PGR؛ Uterus؛ Ovary | ||
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آمار تعداد مشاهده مقاله: 9 تعداد دریافت فایل اصل مقاله: 2 |
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