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Interplay of medicinal plants, toxicants, and chronic diseases: An integrative review | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 16 شهریور 1404 | ||
| نوع مقاله: Reviewers | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2025.9043 | ||
| نویسندگان | ||
| Umida Yunusova* 1؛ Alibek Akhmedov1؛ Luiza Khalilovna Alimova2؛ Nargiza Omonova3؛ Islom Rayimbergan ugli Kadirov4؛ Marif Karimov5؛ Bakhora Khamdamova6؛ Feruzaxon Sultonova7؛ Ibrohimjon Asqarov8؛ Luqmon Samiev9؛ Furkat Gapparov9؛ Saodat Nasirova10 | ||
| 1Department of Orthopedic Dentistry and Orthodontics of the Bukhara State Medical Institute, 23, Gijduvanskaya Str, Bukhara City, 200118, Uzbekistan | ||
| 2Doctor of Philosophy in Biological Sciences, Associate Professor, Bukhara State University, Bukhara, Uzbekistan | ||
| 3Department of Plant Quarantine and Protection, Andijan Institute of Agriculture and Agrotechnologies, Andijan, Uzbekistan | ||
| 4Department of Transport Systems, Urgench State University named after Abu Raykhan Beruni. Urgench, Uzbekistan | ||
| 5Department of Propedeutics of Internal Diseases No. 2 of Tashkent State Medical University, Tashkent, Uzbekistan | ||
| 6Department of Neurology, Faculty of Postgraduate Education, Samarkand State Medical University, Samarkand, Uzbekistan | ||
| 7Department of Chemistry and Chemical Engineering, Andijan State Technical Institute, Andijan, Uzbekistan | ||
| 8Department of Chemistry, Faculty of Natural Sciences, Department of Chemistry, Andijan State University | ||
| 9Tashkent Institute of Irrigation and Agricultural Mechanization Engineers" National Research University, Tashkent, Uzbekistan | ||
| 10Department of Life Safety, Faculty of Geology, Exploration and Mining, Tashkent State Technical University, Tashkent, Uzbekistan | ||
| چکیده | ||
| Chronic diseases result from complex interactions among genetic factors, environmental toxins like metals and air pollutants, lifestyle choices, and our overall exposure. At the same time, medicinal plants and their active components have various effects that may counteract or sometimes worsen these toxin-related processes. Many phytochemicals influence oxidative stress, inflammation, metabolism of foreign substances, hormonal signaling, genetic programming, mitochondrial function, and the gut-microbiome-liver connection—all of which can be disrupted by toxins. The most substantial evidence suggests that polyphenols, alkaloids, terpenoids, and sulfur compounds, such as curcumin, quercetin, resveratrol, berberine, silymarin, EGCG, and sulforaphane, are effective, although their clinical applications vary. These interactions can include benefits such as activating Nrf2, chelating metals, and reshaping the microbiome, as well as risks including inhibiting CYP/P-gp, producing oxidative effects at high doses, and contamination. Plant-based interventions show potential for countering the harmful effects of toxins in chronic conditions like heart disease, liver disease, kidney issues, neurodegenerative disorders, immune problems, and cancer. Future research should focus on trials that consider exposure, validated biomarkers, and integrated methods that connect exposomics and pharmacology. | ||
| کلیدواژه‌ها | ||
| Exposome؛ Endocrine disruptors؛ Epigenetics؛ Oxidative stress؛ Xenobiotic metabolism؛ Gut microbiome؛ Polyphenols؛ Nrf2؛ NF-Κb؛ Herb–drug interaction | ||
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آمار تعداد مشاهده مقاله: 24 |
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