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Antidiabetic and antioxidant effects of sage tea, Salvia officinalis in male rats exposed to hydrogen peroxide as a source of reactive oxygen species | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 22، شماره 2، تیر 2024، صفحه 453-457 اصل مقاله (983.25 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2024.7478 | ||
| نویسندگان | ||
| Sahib M.H. Mohammad Bakir* 1؛ Sadiq M. A. Al-Hiti2؛ Rajiha A. S. Al-Naimi3؛ Dina T. Ali4 | ||
| 1Dentistry College/ Al-Bayan University, Baghdad, Iraq | ||
| 2College of Pharmacy, Baghdad, Iraq | ||
| 3College of Veterinary Medicine Baghdad University, Baghdad, Iraq | ||
| 4Institute of Embryonic Research and Infertility Treatment, Iraq | ||
| چکیده | ||
| The antidiabetic and antioxidant effects of Salvia officinalis (sage tea) were studied in 20 mature male rats for 42 days. The rats were divided into four equal groups and given the following treatments: group one as a control group (C), rats only received tap water; group two (T1) received 0.5% H2O2 as a source of reactive oxygen species (ROS); group three (T2) received sage tea as 2 mg sage in 150 mL boiling water (ad libitum); and group four (T3) received 400 IU/Kg BW/day vitamin E by oral intubation along with 0.5% H2O2. In order to determine serum glucose levels, blood samples were taken directly from the heart after the end of the experiment. Rats were slaughtered, and pancreas samples were collected for patho-histological analysis. The serum glucose levels in the sage tea with the H2O2 group (T2) and T3 as compared to the second group (T1) showed a significant decrease (p ˂ 0.05). Histological examination revealed significant recovery of the pancreatic tissues especially islets of Langerhans in sage tea and vitamin E rats (T3). This investigation suggests the antidiabetic effect of sage tea for H2O2- induced diabetic rats mediated by their effect as antioxidants. | ||
| کلیدواژه‌ها | ||
| Salvia officinalis؛ Hydrogen peroxide؛ Vitamin E؛ Type 2 diabetes mellitus؛ Rat | ||
| مراجع | ||
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Alberti, KG & Zimmet, PZ 1998, New diagnostic criteria and classification of diabetes—again. Diabetic Medicine, 5: 535-536.
Abhinov, T, MdAasif, AK, Ashrafa, Parveen S & Kumar KP 2013, Diabetes epidemic in India: risk factors, symptoms and treatment. Indian Journal of Research in Pharmacy and Biotechnology, 1: 234-243.
Adinortey, MB, Owusu, RK, Galyuon, IKA, Ekloh, W, Owusu, I & Larbi, DA 2011, G-6-PD deficiency - A potential risk factor for development of diabetes mellitus. Journal of Medicine and Medical Science, 2: 1017-1021.
Alarcon Aguilar, FJ, Roman Ramos, R, Flores Saenz, JL & Aguirre Garcia, F 2002, Investigation on the hypoglycaemic effects of extracts of four Mexican medicinal plants in normal and alloxan-diabetic mice. Phytotherapy Research, 16: 383–386.
American Diabetic Association 2010, Diagnosis and classification of Diabetes mellitus. Diabetes Care, 33.
Deokar, P, Jagtap A & Yerawar, C 2016, Correlation of protein carbonyl and MDA in diabetes and its complications. Indian Journal of Basic and Applied Medical Research, 5: 284-289.
Eidi, M, Eidi, A & Zamanizadeh, H 2005, Effect of Salvia officinalis L. leaves on serum glucose and insulin in healthy and streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 100: 310-313.
Eidi, A & Eidi, M 2009, Antidiabetic effects of Sage (Salvia officinalis L.) leaves in normal and streptozotocin-induced diabetic rats. Diabetes & Metabolic Syndrome: Clinical research & Revies, 3: 40-44.
Khademian Amiri, SA, Aghajanzadeh, T, Jafari, N & Mahmoudi, M 2022, Antioxidative compounds, enzymes activity and nutrient elements in Stachys byzantina are altered by climate conditions not by soil parameters. Caspian Journal of Environmental Sciences, 20: 1099-1115.
Klover, PJ & Mooney, RA 2004, Hepatocytes: critical for glucose homeostasis. The International Journal of Biochemistry & Cell Biology, 36: 753-758.
Li, R, Bilik, D, Brown, MB, Zhang, P, Ettner, SL & Ackermann RT et al. 2013, Medical costs associated with type 2 diabetes complications and comorbidities. The American Journal of Managed Care, 19: 421-430.
Li, WL, Zheng, HC, Bukuru, J & De Kimpe, N 2004, Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Journal of Ethnopharmacology, 92: 1-21.
Lima, CF, Azevedo, MF, Araujo, R, Fernandes Ferreira, M & Pereira Wilson, C 2006, Metformin-like effect of Salvia officinalis (common sage): is it useful in diabetes prevention. British Journal of Nutrition, 96: 326-333.
Miura, K, Kikuzaki, H & Nakatani, N 2002, Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. Journal of Agricultural and Food Chemistry, 50: 1845- 1850
Nunthaboot, N, Lugsanangarm, K, Kokpol, S & Abd Elazem, IS 2013, Binding mode prediction of biologically active compounds from plant Salvia miltiorrhiza as integrase inhibitor. Bioinformation, 9: 426-431.
Pierce, JD, Cacker, AB & Arnett, MG 2004, Why should you care about free radicals. RN, 67: 38-42. https://pubmed.ncbi.nlm.nih.gov/14979192/
Sá, CM, Ramos, AA, Azevedo, MF, Lima, CF, Fernandes Ferreira M & Pereira Wilson, C 2009, Sage tea drinking improves lipid profile and antioxidant defences in humans. International Journal of Molecular Sciences, 10: 3937-3950.
Scalbert, A, Manach, C, Morand, C, Rémésy, C & Jiménez, L 2005, Dietary polyphenols and the prevention of diseases. Critical Reviews in Food Science and Nutrition, 45: 287-306.
Salim, SM 2023. Antioxidant activity of Garcinia atroviridis Griff. ex T. Anderson. Caspian Journal of Environmental Sciences, 21: 325-331.
Saxena, A & Vikram, NK 2004, Role of selected Indian plants in management of type 2 diabetes: a review. The Journal of Alternative and Complementary Medicine, 10: 369-378.
Slatter, DA, Bolton CH & Bailey, AJ 2000, The importance of lipid-derived malondialdehyde in diabetes mellitus. Diabetologia, Springer-Verlag, 43: 550-557.
Steel, RG & Torries, JH 1980, Principles and procedures of statistics. Biochemical approach, 2nd Ed., McGraw- Hill book Co., New York, USA.
Traber, MG & Atkinson, J 2007, Vitamin E, antioxidant and nothing more. Free Radical Biology and Medicine, 43: 1.
Wang, Z, Wang, J & Chan, P 2013, Treating type 2 diabetes mellitus with traditional Chinese and Indian medicinal herbs. Evidence-Based Complementary and Alternative Medicine, 343594.
Weekers, F 2003, Metabolic, endocrine and immune effects of stress hyperglycemia in rabbit model of prolonged critical illness. Endocrinology, 144: 5329- 5338.
Wilcox, CS & Gutterman, D 2005, Focus on oxidative stress in the cardiovascular and renal systems. American Journal of Physiology-Heart and Circulatory, 288: 3-6.
Williams, G & Pickup, JC 2004, Handbook of Diabetes, 3rd Ed. Malden: Blackwell Publishing. | ||
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