پیوندهای مفید
آمار
| تعداد نشریات | 31 |
| تعداد شماره‌ها | 708 |
| تعداد مقالات | 6,673 |
| تعداد مشاهده مقاله | 9,219,819 |
| تعداد دریافت فایل اصل مقاله | 6,329,936 |
Effects of the air pollution on the decreased P53, Nrf2 and HO-1 protein levels along with tissue damage caused by oxidative stress in the lung of rat as an animal model | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 10 تیر 1402 اصل مقاله (950.43 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2023.6825 | ||
| نویسندگان | ||
| Mahdi Farhadi1؛ Pejman Mortazavi* 2؛ Saeed Motesaddi Zarandi3؛ Akram Eidi1 | ||
| 1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 3Department of Environmental Health Engineering, School of Public Health and Safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Air pollution is associated with respiratory pathologies, and exposure to airborne particles with an aerodynamic diameter of 2.5 microns (PM2.5) is a significant risk factor for respiratory patients. This study aimed to investigate the effects of PM2.5 exposures on lung tissue pathology and the function of antioxidant enzymes in a rat animal model. The animals were exposed to PM2.5 for two different periods: 3 and 6 months, with a frequency of 4 days per week and a duration of 5 hours (from 9.00 am to 14.00 pm) per day. The activity of antioxidant enzymes, as well as lung histology and the protein expression of p53, Nrf2, and HO-1, were assessed in the lung tissue of the exposed rats. The results revealed a significant increase in malondialdehyde (MDA) levels and a significant decrease in antioxidant enzymes (CAT, SOD, and GPx) in the animals exposed to PM2.5. Moreover, a noticeable reduction in the protein levels of p53, Nrf2, and HO-1 was observed in the lung tissues of the rats after PM2.5 exposure, which was accompanied by pathological changes. In conclusion, PM2.5 exposure leads to severe damage to lung tissue by reducing the activity of antioxidant enzymes and inducing oxidative stress through the activation of Nrf2 and P53 signalling pathways. | ||
| کلیدواژه‌ها | ||
| Air pollution؛ P53؛ Nrf2؛ HO-1؛ Oxidative stress؛ Lung damage | ||
| مراجع | ||
|
Asadifard, E & Masoudi, M 2018, Status and prediction of carbon monoxide as an air pollutant in Ahvaz City, Iran. Caspian Journal of Environmental Sciences, 16: 203-213.
Babaei, H, Alibabrdel, M, Asadian, S, Siavashi, V, Jabarpour, M & Nassiri, SM 2018, Increased circulation mobilization of endothelial progenitor cells in preterm infants with retinopathy of prematurity. Journal of Cellular Biochemistry, 119, 6575-6583.
Bernstein, JA, Alexis, N, Barnes, C, Bernstein, IL, Nel, A, Peden, D, Diaz-Sanchez, D, Tarlo, SM & Williams, PB 2004, Health effects of air pollution. Journal of Allergy and Clinical Immunology, 114: 1116-1123.
Block, ML & Calderón-Garcidueñas, L 2009, Air pollution: mechanisms of neuroinflammation and CNS disease. Trends in Neurosciences, 32: 506-516.
Chauhan, AJ, Johnston, SL 2003, Air pollution and infection in respiratory illness. British Medical Bulletin, 68: 95-112.
Chen, X, Liu, S, Zhang, W, Wu, C, Liu, H, Zhang, F & Ding, W 2018, Nrf2 deficiency exacerbates PM2 5-induced olfactory bulb injury. Biochemical and Biophysical Research Communications, 505: 1154-1160.
Cho, CC, Hsieh, WY, Tsai, CH, Chen, CY, Chang, HF & Lin, CS 2018, In vitro and in vivo experimental studies of PM2.5 on disease progression. International Journal of Environmental Research and Public Health, 15: 1380.
Donaldson, K, Beswick, PH & Gilmour, PS1996, Free radical activity associated with the surface of particles: A unifying factor in determining biological activity? Toxicology Letters, 88: 293-298.
Duncan, K 2006, Global climate change, air pollution, and women’s health. WIT Transactions on Ecology and the Environment, 99.
Feroz, W & Sheikh, AMA 2020, Exploring the multiple roles of guardian of the genome: P53. Egyptian Journal of Medical Human Genetics, 21: 1-23.
Fiorito, G, Vlaanderen, J, Polidoro, S, Gulliver, J, Galassi, C, Ranzi, A et al. 2018, Oxidative stress and inflammation mediate the effect of air pollution on cardio‐and cerebrovascular disease: A prospective study in nonsmokers. Environmental and Molecular Mutagenesis, 59: 234-246.
Gawda, A, Majka, G, Nowak, B & Marcinkiewicz, J 2017, Air pollution, oxidative stress, and exacerbation of autoimmune diseases. Central-European Journal of Immunology, 42: 305.
Ge, C, Hu, L, Lou, D, Li, Q, Feng, J, Wu, Y & Xu, M 2020, Nrf2 deficiency aggravates PM2.5 5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder. Aging (Albany NY), 12: 4836.
Gemenetzis, P, Moussas, P, Arditsoglou, A & Samara, C 2006, Mass concentration and elemental composition of indoor PM2.5 and PM10 in University rooms in Thessaloniki, northern Greece. Atmospheric Environment, 40: 3195-3206.
Ghorani-Azam, A, Riahi-Zanjani, B & Balali-Mood, M 2016, Effects of air pollution on human health and practical measures for prevention in Iran. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 21: 65, DOI: 10.4103/1735-1995.189646
Hassanvand, MS, Naddafi, K, Faridi, S, Arhami, M, Nabizadeh, R, Sowlat, MH, Yunesian, M 2014, Indoor/outdoor relationships of PM10, PM2.5, and PM1 mass concentrations and their water-soluble ions in a retirement home and a school dormitory. Atmospheric Environment, 82: 375-382.
Holý, O & Matoušková, I 2012, The importance of cleanrooms for the treatment of haemato-oncological patients. Contemporary Oncology, 16: 266.
Jabarpour, M, Siavashi, V, Asadian, S, Babaei, H, Jafari, SM & Nassiri, SM 2018, Hyperbilirubinemia-induced pro-angiogenic activity of infantile endothelial progenitor cells. Microvascular Research, 118: 49-56.
Jalali-Mashayekhi, F 2020, Oxidative toxic stress and p53 level in healthy subjects occupationally exposed to outdoor air Pollution–a cross-sectional study in Iran. Annals of Agricultural and Environmental Medicine, 27: 585-590.
Jimenez, LA, Drost, EM, Gilmour, PS, Rahman, I, Antonicelli, F, Ritchie, H & Donaldson, K 2002, PM10-exposed macrophages stimulate a proinflammatory response in lung epithelial cells via TNF-α. American Journal of Physiology-Lung Cellular and Molecular Physiology, 282: L237-L248.
Kaspar, JW, Niture, SK, Jaiswal, AK 2009, Nrf2: INrf2 (Keap1) signaling in oxidative stress. Free Radical Biology and Medicine, 47: 1304-1309.
Keshavarz, S, Nassiri, SM, Siavashi, V & Alimi, NS 2019, Regulation of plasticity and biological features of endothelial progenitor cells by MSC-derived SDF-1. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 1866: 296-304.
Kooter, IM, Frederix, K, Spronk, HM, Boere, AJF, Leseman, DL, Steeg, HV & Cassee, FR 2008, Lung inflammation and thrombogenic responses in a time course study of Csb mice exposed to ozone. Journal of Applied Toxicology: An International Journal, 28: 779-787.
Lodovici, M & Bigagli, E 2011, Oxidative stress and air pollution exposure. Journal of Toxicology, 2011: 487074, DOI: 10.1155/2011/487074
Manouchehri, A, Ghareghani, S, Shamaei, S, Nilechi, M & Bossaghzadeh, F 2021, A review on aluminum phosphide (rice tablets) poisoning: From exposure to the applicable and new strategies of clinical management. Advancements in Life Sciences, 8: 326-332.
Marginean, C, Popescu, MS, Vladaia, M, TudorascU, D, Pirvu, DC & Petrescu, F 2018, Involvement of oxidative stress in COPD. Current Health Sciences Journal, 44: 48.
Masoudi, M, Behzadi, F & Sakhaei, M 2019, Assessment of NO2 levels as an air pollutant and its statistical modelling using meteorological parameters in Tehran, Iran. Caspian Journal of Environmental Sciences, 17: 227-236.
Mehrandish, R, Rahimian, A & Shahriary A 2019, Heavy metals detoxification: A review of herbal compounds for chelation therapy in heavy metals toxicity. Journal of Herbmed Pharmacology, 8: 69-77.
Mehta, M, Chen, LC, Gordon, T, Rom, W & Tang, MS 2008, Particulate matter inhibits DNA repair and enhances mutagenesis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 657: 116-121.
Moon, DH, Kwon, SO, Kim, SY & Kim, WJ 2020, Air pollution and incidence of lung cancer by histological type in Korean adults: A Korean National Health Insurance Service Health Examinee Cohort Study. International Journal of Environmental Research and Public Health, 17: 915.
Oloyede, AM, Ottu B, Ogunsanwo, K, Bolarinwa, K, Makinde, K 2020, Evaluating the genotoxic and proximate analysis of ethanolic extract of Lecaniodiscus cupanioides. Plant Biotechnology Persa, 2: 14-20.
Oren, M 2003, Decision making by p53: Life, death and cancer. Cell Death & Differentiation, 10: 431-442.
Pardo, M, Xu, F, Shemesh, M, Qiu, X, Barak, Y, Zhu, T & Rudich, Y 2019, Nrf2 protects against diverse PM2. 5 components-induced mitochondrial oxidative damage in lung cells. Science of the Total Environment, 669: 303-313.
Rao UM 2023 2022, An Overview of the Most Important Herbal Antimicrobial Generic Drugs in Iran's Pharmaceutical Market. Journal of Biochemicals and Phytomedicine: 1: 1-2.
Riediker, M, Zink, D, Kreyling, W, Oberdörster, G, Elder, A, Graham, U & Cassee, F 2019, Particle toxicology and health-where are we?. Particle and Fibre Toxicology, 16: 1-33
Siavashi, V, Nassiri, SM, Rahbarghazi R, Mohseni, Z & Sharifi, AM 2019, Distinct Tie2 tyrosine phosphorylation sites dictate phenotypic switching in endothelial progenitor cells. Journal of Cellular Physiology, 234: 6209-6219.
Sint, T, Donohue, JF & Ghio, AJ 2008, Ambient air pollution particles and the acute exacerbation of chronic obstructive pulmonary disease. Inhalation Toxicology, 20: 25-29.
Song, L, Li, D, Li, X, Ma, L, Bai, X, Wen, Z & Peng, L 2017, Exposure to PM2.5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression. Environmental Toxicology and Pharmacology, 50: 192-199.
Vafaei, R, Nassiri, SM, Siavashi, V 2017, β3‐Adrenergic regulation of EPC features through manipulation of the bone marrow MSC niche. Journal of Cellular Biochemistry, 118: 4753-4761.
Wang, J, Li, Y, Zhao, P, Tian, Y, Liu, X, He, H & Li, J 2020, Exposure to air pollution exacerbates inflammation in rats with preexisting COPD. Mediators of Inflammation, DOI: 10.1155/2020/4260204
Xing, YF, Xu, YH, Shi, MH, Lian, YX 2016, The impact of PM2. 5 on the human respiratory system. Journal of Thoracic Disease, 8: 69.
Zarandi, SM, Shahsavani, A, Khodagholi, F, Fakhri, Y 2019, Concentration, sources and human health risk of heavy metals and polycyclic aromatic hydrocarbons bound PM 2.5 ambient air, Tehran, Iran. Environmental Geochemistry and Health, 41: 1473-1487.
Zhang, G, Jiang, F, Chen, Q, Yang, H, Zhou, N, Sun, L, & Ao, L 2020, Associations of ambient air pollutant exposure with seminal plasma MDA, sperm mtDNA copy number, and mtDNA integrity. Environment International, 136: 105483.
Zhu, Z, Oh, SY, Zheng, T & Kim, YK 2010, Immunomodulating effects of endotoxin in mouse models of allergic asthma. Clinical & Experimental Allergy, 40: 536-546. | ||
|
آمار تعداد مشاهده مقاله: 144 تعداد دریافت فایل اصل مقاله: 135 |
||