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Effects of inhaled particulate matter (PM2.5) on uterine quality in female rats as an animal model | ||
| Caspian Journal of Environmental Sciences | ||
| مقالات آماده انتشار، اصلاح شده برای چاپ، انتشار آنلاین از تاریخ 10 تیر 1402 اصل مقاله (1.32 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2023.6823 | ||
| نویسندگان | ||
| Nazli Yazdani Karganrood1؛ Pejman Mortazavi* 2؛ Saeed Motesaddi zarandi3؛ Akram Eidi1 | ||
| 1Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 3Department of Environmental Health Engineering, School of public Health and safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran | ||
| چکیده | ||
| Air pollution plays an important role in the health of reproduction. Studies on the destructive effects of environmental pollutants have been focused more on their effects on testicular and sperm quality, while the study on the female reproductive system has received less attention. Therefore, in this study, the effects of PM2.5 on the female mice's uterine quality were assessed. A total of 24 Wistar albino rats were divided into three treatments and control for a three months’ period. Three groups were defined including healthy control (C) that used air with a clean standard condition, Treatment 1 (T1) was exposed to only gaseous pollutants, while treatment 2 (T2) to gaseous pollutants plus PM2.5. Uterus tissue was removed after dissection of rats, then the oestrogen and progesterone receptors, immunohistochemical assays, and oxidative stress activity for all groups were evaluated. The activity of enzymes involved in oxidative stress (MDA, SOD, GPx, and CAT) in the treatment and control groups were examined in mice uterus tissue after three months. T1 and T2 showed a statistically significant decrease in SOD, GPx, and CAT compared to control. On the other hand, T2 exhibited a significant decline in these enzymes compared to T1. In the case of MDA, T1 and T2 displayed a significant elevation compared to control (p < 0.01 and p < 0.001) respectively, while T2 indicated a significant decrease compared to T1 (p < 0.01). In T2, the estrogen and progesterone receptors (ER and PR) Immunohistochemical results showed a sharp drop compared to control and T1. Serious programs should be implemented to control and reduce PM2.5 emissions in metropolitan areas. These findings may be useful to provide insights for reducing infertility disorders caused by exposure to PM2.5 or other air pollutants. | ||
| کلیدواژه‌ها | ||
| Immunohistochemical assay؛ PM2.5؛ Pollution؛ Stress oxidative؛ Uterus | ||
| مراجع | ||
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