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پاآهو, علیرضا, تادیبی, وحید, بهپور, ناصر. (1401). نقش فعالیت بدنی بر بهبود تنظیم کننده‌های درون‌زاد آترواسکلروز در کودکان چاق و بی‌تحرک: مروری جامع بر برخی شاخص‌های پیش تا ضد آترواسکلروزی. فیزیولوژی و بیوتکنولوژی آبزیان, 12(1), 173-204. doi: 10.22124/jme.2023.23904.241
علیرضا پاآهو; وحید تادیبی; ناصر بهپور. "نقش فعالیت بدنی بر بهبود تنظیم کننده‌های درون‌زاد آترواسکلروز در کودکان چاق و بی‌تحرک: مروری جامع بر برخی شاخص‌های پیش تا ضد آترواسکلروزی". فیزیولوژی و بیوتکنولوژی آبزیان, 12, 1, 1401, 173-204. doi: 10.22124/jme.2023.23904.241
پاآهو, علیرضا, تادیبی, وحید, بهپور, ناصر. (1401). 'نقش فعالیت بدنی بر بهبود تنظیم کننده‌های درون‌زاد آترواسکلروز در کودکان چاق و بی‌تحرک: مروری جامع بر برخی شاخص‌های پیش تا ضد آترواسکلروزی', فیزیولوژی و بیوتکنولوژی آبزیان, 12(1), pp. 173-204. doi: 10.22124/jme.2023.23904.241
پاآهو, علیرضا, تادیبی, وحید, بهپور, ناصر. نقش فعالیت بدنی بر بهبود تنظیم کننده‌های درون‌زاد آترواسکلروز در کودکان چاق و بی‌تحرک: مروری جامع بر برخی شاخص‌های پیش تا ضد آترواسکلروزی. فیزیولوژی و بیوتکنولوژی آبزیان, 1401; 12(1): 173-204. doi: 10.22124/jme.2023.23904.241

نقش فعالیت بدنی بر بهبود تنظیم کننده‌های درون‌زاد آترواسکلروز در کودکان چاق و بی‌تحرک: مروری جامع بر برخی شاخص‌های پیش تا ضد آترواسکلروزی

سوخت و ساز و فعالیت ورزشی
دوره 12، شماره 1، فروردین 1401، صفحه 173-204    اصل مقاله (707.98 K)
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
شناسه دیجیتال (DOI): 10.22124/jme.2023.23904.241
نویسندگان
علیرضا پاآهو* 1؛ وحید تادیبی2؛ ناصر بهپور2
1دبیر آموزش و پرورش اسلام آباد غرب
2گروه فیزیولوژی ورزشی، دانشکده تربیت بدنی و علوم ورزشی، دانشگاه رازی، کرمانشاه، ایران
چکیده
آترواسکلروز یک بیماری مزمن است که نخستین مرحله‌های آن می‌تواند از دوره کودکی آغاز شوند. چاقی از عوامل عمده خطر بیماری آترواسکلروز است که در حال تبدیل شدن به اپیدمی است. افزایش شیوع چاقی موجب تمرکز بیشتر بر رابطه چاقی با آترواسکلروز شده است و اگرچه ارتباط چاقی با بیماری آترواسکلروز به‌طور گسترده‌ای گزارش شده است، اما سازوکارهای بالقوه آن هنوز نیاز به توضیح بیشتری دارند. سالوسین‌ها دسته جدیدی از پپتیدهای زیست فعال هستند که نقش مهمی به‌عنوان تنظیم کننده‌های درون‌زاد فرایند آترواسکلروز بازی می‌کنند. چاقی با یک پاسخ التهابی مزمن همراه است که به‌واسطه تولید غیرطبیعی آدیپوکین و فعال شدن بعضی از مسیرهای سیگنالینگ پیش‌التهابی مشخص می‌شود. مطالعات گذشته نشان داده‌اند که فرایند التهابی با چاقی و بیماری‌های قلبی-عروقی، از جمله آترواسکلروز رابطه علت و معلول دارند. همچنین، اختلال اندوتلیال شریانی یک اختلال اولیه در فرآیند آترواسکلروز است و وجود این اختلال در کودکان چاق به‌طورگسترده گزارش شده است. مهم‌ترین عامل بالقوه‌ای که چاقی، وضعیت‌های التهابی و اختلال اندوتلیالی را به دنبال خواهد داشت، بی‌تحرکی است. از سوی دیگر، فعالیت بدنی سودمندی‌های سلامت گسترده‌ای دارد و به عنوان عامل مهمی در پیشگیری اولیه و ثانویه از بیماری‌های قلبی-عروقی در نظر گرفته می‌شود. بنابراین، پژوهش حاضر به‌دنبال بررسی نقش فعالیت بدنی در بهبود تنظیم کننده‌های درون‌زاد آترواسکلروزی در کودکان چاق و بی‌تحرک است.
کلیدواژه‌ها
سالوسین آلفا؛ سالوسین بتا؛ پروتئین واکنشی-C؛ اینترلوکین-6؛ نیتریک اکساید
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