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داداش زاده, امیر, پوزش جدیدی, رقیه, آذین فام, امید, پوزش جدیدی, جبرئیل. (1401). تاثیر تمرین هوازی و مکمل کورکومین بر برخی شاخص‌های میتوفاژی ناشی از ایسکمی/خونرسانی مجدد کلیه موش‌های صحرایی نر. فیزیولوژی و بیوتکنولوژی آبزیان, 12(2), -. doi: 10.22124/jme.2023.23952.250
امیر داداش زاده; رقیه پوزش جدیدی; امید آذین فام; جبرئیل پوزش جدیدی. "تاثیر تمرین هوازی و مکمل کورکومین بر برخی شاخص‌های میتوفاژی ناشی از ایسکمی/خونرسانی مجدد کلیه موش‌های صحرایی نر". فیزیولوژی و بیوتکنولوژی آبزیان, 12, 2, 1401, -. doi: 10.22124/jme.2023.23952.250
داداش زاده, امیر, پوزش جدیدی, رقیه, آذین فام, امید, پوزش جدیدی, جبرئیل. (1401). 'تاثیر تمرین هوازی و مکمل کورکومین بر برخی شاخص‌های میتوفاژی ناشی از ایسکمی/خونرسانی مجدد کلیه موش‌های صحرایی نر', فیزیولوژی و بیوتکنولوژی آبزیان, 12(2), pp. -. doi: 10.22124/jme.2023.23952.250
داداش زاده, امیر, پوزش جدیدی, رقیه, آذین فام, امید, پوزش جدیدی, جبرئیل. تاثیر تمرین هوازی و مکمل کورکومین بر برخی شاخص‌های میتوفاژی ناشی از ایسکمی/خونرسانی مجدد کلیه موش‌های صحرایی نر. فیزیولوژی و بیوتکنولوژی آبزیان, 1401; 12(2): -. doi: 10.22124/jme.2023.23952.250

تاثیر تمرین هوازی و مکمل کورکومین بر برخی شاخص‌های میتوفاژی ناشی از ایسکمی/خونرسانی مجدد کلیه موش‌های صحرایی نر

سوخت و ساز و فعالیت ورزشی
دوره 12، شماره 2، مهر 1401    اصل مقاله (815.28 K)
نوع مقاله: مقاله پژوهشی Released under (CC BY-NC) license I Open Access I
شناسه دیجیتال (DOI): 10.22124/jme.2023.23952.250
نویسندگان
امیر داداش زاده1؛ رقیه پوزش جدیدی* 2؛ امید آذین فام1؛ جبرئیل پوزش جدیدی1
1گروه تربیت بدنی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران
2استادیار، گروه تربیت بدنی، واحد تبریز، دانشگاه آزاد اسلامی، تبریز، ایران
چکیده
هدف مطالعه حاضر تعیین تاثیر تمرین هوازی و مکمل کورکومین بر برخی شاخص‌های میتوفاژی ناشی از ایسکمی/خونرسانی مجدد کلیه موش‌های صحرایی نر بود. روش شناسی: 50 سر موش صحرائی نر (12 هفته‌ای با وزن 57/28 ± 23/315) پس از القای ایسکمی کلیه، به طور تصادفی در پنج گروه کنترل سالم، کنترل ایسکمی، تمرین، کورکومین، تمرین + کورکومین تقسیم شدند. برنامه تمرین هوازی شامل هشت هفته متشکل از پنج جلسه تمرین در هر هفته بود که هر جلسه با سرعت 10 متر در دقیقه، شیب 5 درصد به مدت 10 دقیقه در روز، آغاز شد. سرعت و زمان دویدن به تدریج تا 15 متر در دقیقه به مدت 20 دقیقه در روز افزایش یافت. در دو جلسه آخر شدت فعالیت هوازی به 25 متر در دقیقه و به مدت 30 دقیقه در روز رسید. هر جلسه دو دقیقه گرم کردن و سرد کردن با سرعت 10 متر در دقیقه انجام شد. اما نسبت به گروه تمرین معنی‌دار (به ترتیب 7/0=p و 1/0=p) نبود. نتیجه‌گیری: ایسکمی کلیوی موجب افزایش بیان ژن‌های Bnip3 و HIF-1α می شود اما به دنبال 8 هفته تمرین هوازی بیان ژن HIF-1α کاهش و بیان ژن Bnip3 افزایش یافت.
کلیدواژه‌ها
میتوفاژی؛ کورکومین؛ هوازی؛ HIF-1α؛ Bnip3
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