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Zveoboy extended Hypericum elongatum Ldb.: Phytochemical composition, biological activity and prospects of application in pharmacy | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 24، شماره 4، دی 2026، صفحه 1289-1297 اصل مقاله (1016.95 K) | ||
| نوع مقاله: Reviewers | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2026.10077 | ||
| نویسندگان | ||
| Rakhat Pernebekova1؛ Roza Mamykova* 2؛ Galiya Zhakipbekova* 3؛ Rabiga Anarbayeva3؛ Aigul Ibragimova3؛ Khalima Sartayeva2؛ Ayaulym Zholbarys3؛ Kozhayev Galymtay4 | ||
| 1Faculty of Postgraduate Higher Medical Education, Khoja Akhmet Yassawi International Kazakh-Turkish University, Turkestan, Kazakhstan | ||
| 2Faculty of Natural Sciences, Zhanibekov University, Department of Biology, Shymkent, Kazakhstan | ||
| 3South Kazakhstan Medical Academy, Shymkent, Kazakhstan | ||
| 4Sh. Ualikhanov University, Kokshetau, Kazakhstan | ||
| چکیده | ||
| Hypericum elongatum Ledeb. is a promising and understudied species of the genus Hypericum, whose natural range includes parts of Central Asia, including the southern regions of Kazakhstan. Despite its taxonomic proximity to St. John's wort (Hypericum perforatum L.), which has been widely studied as a source of standardized medicinal raw materials, H. elongatum has a much less well-known phytochemical profile and a limited evidence base on pharmacological activity. The purpose of this review is to systematize, critically evaluate, and integrate available scientific data on the botanical and pharmacological properties, distribution, chemical composition, biological activity, and medicinal potential of H. elongatum, emphasizing its resource value for Kazakhstan. Information on secondary metabolites of this species, including phenolic compounds, flavonoids, xanthones, phloroglucinols, terpenoids, and other classes of natural compounds, along with modern approaches for their identification and quantification, are summarized. Experimental data on antioxidant, anti-inflammatory, antimicrobial, cytotoxic and other biological activities of H. elongatum extracts and single compounds have been critically analyzed. The scientific innovation of this review is the systematization of scattered data on H. elongatum along with the simultaneous comparison of its phytochemical and biological profiles with H. perforatum, a pharmacopoeia that allows the separation of species-specific properties from common properties of the Hypericum genus. Special attention is paid to identifying gaps in modern research, including insufficient standardization of plant raw materials, limited data on the quantitative content of indicator compounds, lack of standard criteria for evaluating biological activity, and insufficient study of mechanisms of action. The obtained results allow to consider H. elongatum not as a direct pharmacopoeial analogue of H. perforatum, but as a promising independent source of bioactive compounds and a potentially valuable plant resource for Kazakhstan, which requires further pharmacognosy, phytochemical, pharmacological and toxicological evaluation. A promising direction is the development of a scientific evidence-based standardization system for H. elongatum raw materials, which is based on the identification of species-specific chemical markers, the evaluation of their variability based on geographic origin and vegetative stage, and also determining the relationship between chemical profile and biological activity. | ||
| کلیدواژه‌ها | ||
| Hypericum elongatum Ledeb؛ Kazakhstan؛ Phytochemical composition؛ Secondary metabolites؛ Flavonoids؛ Biological activity؛ Pharmaceutical potential؛ Hypericum perforatum | ||
| مراجع | ||
|
Abd El-Aziz, MA, Ibrahim, HM, Abo El-Roos, N, Anis, B & Elsabagh, R 2020, Nanotechnological enhancement of meat balls quality. Proceedings on Engineering Sciences, 2(3): 323–332. https://doi.org/10.24874/ PES02.03.011.
Abu Siam, F, Abu-Romman, S, Al-Rubaye, SAK, Al-Mohusaien, RM & Sadder, MT 2026, Vsapx1 is up-regulated by ABA and heat stress in common vetch (Vicia sativa). International Journal of Plant Biology, 17(3): 16. https://doi.org/10.3390/ijpb17030016.
Ahmed, KAA, Shareef, SH, Nanakaly, HT, Ali, MA, Fisal, DN, Aziz, PY, Agha, NFS, Abdulla, MA & Salman, AA 2025, Mangiferin: A novel hepatoprotective for liver cirrhosis via modulation of histological, cellular, biochemical, inflammatory markers and oxidative stress. BMC Pharmacology and Toxicology, 27(1): Article 26. https://doi.org/10.1186/s40360-025-01061-4.
Akdeniz, M, Yilmaz, MA, Ertas, A, Yener, I, Firat, M, Aydin, F & Kolak, U 2020, Method validation of 15 phytochemicals in Hypericum lysimachioides var. spathulatum by LC–MS/MS, and fatty acid, essential oil, and aroma profiles with biological activities. Journal of Food Measurement and Characterization, 14: 3194–3205.
Al-ebini, Y, Chandramouli, M, Koppuravuri, NP, Pasha, TY, Rahamathulla, M, Eltawaty, S, Thajudeen, KY, Ahmed, MM & Shivanandappa, TB 2026, Design, docking, synthesis, and biological evaluation of pyrazolone derivatives as potential dual-action antimicrobial and antiepileptic agents. Pharmaceuticals, 19(2): 193. https://doi.org/10.3390/ph19020193.
Al-Hussaniy, HA, Ali, KA, Jasim, ST & Al-Samydai, A 2026, Data-driven toxicity prediction: Advances in machine learning, deep learning, and predictive tools – a systematic review. Current Reviews in Clinical and Experimental Pharmacology, 21. https://doi.org/10.2174/0127724328441651260211220550.
Al-Karmalawy, AA, Attia, MI, Sharaky, M, Khatib, AOA, Yousef, TA & Hawas, SS 2026, Designing telomerase inhibitors for cancer therapy: Mechanistic insights, medicinal chemistry strategies, challenges, and future directions. Archiv der Pharmazie, 359(5): Article e70250. https://doi.org/10.1002/ardp.70250.
Almajali, B, Abdulsahib, WK, Jyothi, SR, Nayak, PP, Chauhan, AS, Singla, S, Atakhanova, N, Bahoush, G & Akhavan-Sigari, R 2026, Application of niosomes in cancer nanotheranostics: Recent progress and prospects. International Immunopharmacology, 170: 116070. https://doi.org/10.1016/j.intimp.2025.116070.
Al-Mohusain, R, Shibli, R, Alghsoon, R & Qudah, TA 2026, Neglected and underutilized food plants: Prospects in the Near East and North Africa. A review. Revista Brasileira de Engenharia Agrícola e Ambiental, 30(2): Article e294501. https://doi.org/10.1590/1807-1929/agriambi.v30n2e294501.
Al-Sawa’eer, AS, Al-Samydai, A, Odeh, L, Haj Ahmad, F, Obekh, R, Elqader, YMA, Khaleel, A, Al-Athamneh, AM, Gabriele, M, Di Simone, SC, Ferrante, C, Menghini, L & Ali Agha, ASA 2026, Early plant development as a systems-level trait: Integrating omics, artificial intelligence, and emerging biotechnologies. Plants, 15(5): 787. https://doi.org/10.3390/plants15050787.
Baljak, J, Bogavac, M, Karaman, M, Srđenović Čonić, B, Vučković, B, Anačkov, G & Kladar, N 2024, Chemical composition and biological activity of Hypericum species: H. hirsutum, H. barbatum, H. rochelii. Plants, 13(20): 2905. https://doi.org/10.3390/plants13202905.
Behera, SK, Murali Krishna Muktinutalapati, MVB, Sethy, PK, Varma, NUB, Nanthaamornphong, A & Smerat, A 2026, Assessment of nutrient deficiency of rice plant based on modified ResNet50. Open Life Sciences, 21(1): Article 20251281. https://doi.org/10.1515/biol-2025-1281.
Budantsev, AL, Prikhodko, VA, Varganova, IV & Okovityi, SV 2021, Biological activity of Hypericum perforatum L. (Hypericaceae): A review. Pharmacy & Pharmacology, 9(1): 17–31.
Burunkaya, B, Selli, S & Kelebek, H 2021, Characterization of phenolics and determination of antioxidant and antimicrobial potential of St John's wort (Hypericum perforatum L.) plant. Çukurova Journal of Agriculture and Food Science, 36(2): 309–324.
Canpolat, Ş & Canpolat, EY 2023, Antioxidant and antimicrobial activity of a medicinal mushroom, Ganoderma lucidum. Journal of Advances in Biology & Biotechnology, 26(11): 60–67.
Canpolat, Ş, Yürümez Canpolat, E & İşlek, C 2024, The biological activities of Hypericum perforatum L. ISPEC Journal of Agricultural Sciences, 8(4): 1001–1012. https://doi.org/10.5281/zenodo.13736189.
Chen, H, Muhammad, I, Zhang, Y, Ren, Y, Zhang, R, Huang, X, Diao, L, Liu, H, Li, G, Sun, X, Abbas, G & Li, G 2019, Antiviral activity against infectious bronchitis virus and bioactive components of Hypericum perforatum L. Frontiers in Pharmacology, 10: 470683.
Dunska, A & Zhaldak, H 2021, Study of social capital and enterprise activity involving a pharmaceutical manufacturer. Economic Annals-XXI, 187(1–2): 99–113.
Eruygur, N, Ucar, E, Akpulat, HA, Shahsavari, K, Safavi, SM & Kahrizi, D 2019, In vitro antioxidant assessment, screening of enzyme inhibitory activities of methanol and water extracts and gene expression in Hypericum lydium. Molecular Biology Reports, 46(2): 2121–2129.
Grafakou, ME, Barda, C, Karikas, GA & Skaltsa, H 2022, Hypericum essential oils: Composition and bioactivities: An update (2012–2022). Molecules, 27(16): 5246.
Gül, LB, Özdemir, N, Gül, O, Cırak, C & Con, AH 2021, Some bioactive properties and antimicrobial activity of some Hypericum species growing wild in Black Sea Region of Turkey. European Food Science and Engineering, 2(1): 1–6.
Hamza, AA, Albassam, T, Abdulhussein, AH, Ghazy, H, Al-Mashhadani, ZI, Fadhil, ST, Gupta, M & Dadaxon, A 2025, Fig leaves as waste-derived activated carbons for effective absorption of amoxicillin drug: Isotherm and regeneration study. Procedia Environmental Science, Engineering and Management, 12(2): 485–494.
Kapoor, S, Chandel, R, Kaur, R, Kumar, S, Kumar, R, Janghu, S, Kaur, A & Kumar, V 2023, The flower of Hypericum perforatum L.: A traditional source of bioactives for new food and pharmaceutical applications. Biochemical Systematics and Ecology, 110: 104702.
Khurramovna, SS, Khaydarova, DS, Boltayevich, RA, Murodbekovich, AD, Xasanova, N & Durdiev, NK 2024, Green biosynthesis of copper nanoparticles using citrus fruit extracts for enhanced catalytic and antimicrobial properties. Procedia Environmental Science, Engineering and Management, 11(3): 347–360.
Kırmızı Sönmez, Nİ, Güler, E, Çam, ME, Ermanoğlu, M, Gürdal, B, Taşkın, T & Omurtag, GZ 2022, Investigation of antioxidant and anticonvulsant activity of Hypericum triquetrifolium Turra. Journal of Research in Pharmacy: 1877–1883.
Kisa, O, Oksuz, L, Servi, H & Aysal, AI 2023, Antibacterial activity of Hypericum perforatum L. (St. John's wort) extracts against Gram-positive bacteria and characterisation of its secondary metabolites. Natural Product Research: 1–8.
Mohammad, SI, Vasudevan, A, Abed, BS, Odiljonova, N, Amonova, Z, Xudayorova, S, Karomatova, F & Gati, MA 2026, Production of agricultural products to replace pharmaceutical and health materials: Pharmaceutical and health industry. Procedia Environmental Science, Engineering and Management, 13(1): 317–324.
Saddiqe, Z, Naeem, I, Hellio, C, Patel, AV & Abbas, G 2020, Phytochemical profile, antioxidant and antibacterial activity of four Hypericum species from the UK. South African Journal of Botany, 133: 45–53.
Saleh, MM, Alsarayreh, N, Aladaileh, N, Ijjeh, Y, Alqudah, DA, Al-Zain, H, Alkhatib, HS, Amarin, M, Abdeljaleel, M, Murshidi, R & Alshaer, W 2026, Design of liposomal tocopherol phosphate for dermal applications. International Journal of Pharmaceutics, 690: 126571. https://doi.org/10.1016/j.ijpharm.2026 .126571.
Sarikurkcu, C, Locatelli, M, Tartaglia, A, Ferrone, V, Juszczak, AM, Ozer, MS & Tomczyk, M 2020, Enzyme and biological activities of the water extracts from the plants Aesculus hippocastanum, Olea europaea and Hypericum perforatum that are used as folk remedies in Turkey. Molecules, 25(5): 1202.
Sherif, MM, Elshikh, HH, Abdel-Aziz, MM, Elaasser, MM & Yosri, M 2023, In vitro antibacterial and phytochemical screening of Hypericum perforatum extract as potential antimicrobial agents against multi-drug-resistant (MDR) strains of clinical origin. BioMed Research International: 1–10.
Silva, AR, Taofiq, O, Ferreira, IC & Barros, L 2021, Hypericum genus cosmeceutical application – A decade comprehensive review on its multifunctional biological properties. Industrial Crops and Products, 159: 113053.
Tusevski, O, Todorovska, M, Todorovska, I, Stanoeva, JP & Simic, SG 2024, Photoperiod modulates the production of biologically active compounds in Hypericum perforatum L. hairy roots: An in vitro and in silico approach. Plant Cell, Tissue and Organ Culture, 156(3): 96. | ||
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آمار تعداد مشاهده مقاله: 9 تعداد دریافت فایل اصل مقاله: 4 |
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