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Influence of cadmium chloride and enterosorbents on the lymph dynamics and lymph components | ||
| Caspian Journal of Environmental Sciences | ||
| دوره 24، شماره 4، دی 2026، صفحه 1167-1176 اصل مقاله (1.1 M) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22124/cjes.2026.10042 | ||
| نویسندگان | ||
| Marzhan Kulbayeva1؛ Gulshat Atanbaeva* 1؛ Aigul Mamataeva* 2؛ Zhumadil Childebayev3؛ Issayeva Nazym1؛ Sandugash Mankibaeva1؛ Anar Tolebaeva1؛ Serik Abdreshov1 | ||
| 1Faculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty, Kazakhstan | ||
| 2Department of Biology, Kazakh National Women's Pedagogical University, Almaty, Kazakhstan | ||
| 3Faculty of Natural Sciences and Geography, Abai Kazakh National Pedagogical University, Almaty, Kazakhstan | ||
| چکیده | ||
| The effects of cadmium ions and sorbents on lymphatic dynamics and lymph composition were studied. Experiments showed that prolonged cadmium chloride poisoning (orally) in rats causes changes in the biochemical composition and physicochemical parameters of lymph and blood plasma. After rats were intoxicated with cadmium chloride for 30 days, an increase in the volume of the cervical and mesenteric lymph nodes was observed. They were edematous and distended, and the superficial blood vessels in the node capsule were dilated. A decrease in lymph flow from the intestinal lymphatic vessel and a decrease in blood pressure were observed. A decrease in the viscosity of the dry residue of blood plasma and lymph was observed after rat poisoning with cadmium ions. An accumulation of cadmium ions was noted in the lymph nodes, where their concentration increased by 5-7 times from the baseline. Preliminary administration of sorbents significantly reduced the negative effect of cadmium on lymphatic dynamics and lymph parameters. The natural sorbent tagan enhances the detoxifying functions of the lymphatic system, enhancing tissue drainage and the elimination of cadmium ions from the body. | ||
| کلیدواژه‌ها | ||
| Lymph؛ Lymphdynamics؛ Blood؛ Plasma؛ Tagan sorbents | ||
| مراجع | ||
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Abdreshov, SN, Atanbaeva, GK, Tuleuhanov, ST, Dolkyn, M, Ragipova, FK & Ziadayeva, AO 2019, Determination of biochemical changes in the blood and lymph after poisoning zinc salts animals. Al-Farabi KazNU Experimental Biology, (3): 192–200.
Abdreshov, SN, Bulekbaeva, LE & Demchenko, GA 2015, Lympho- and hemodynamics in dogs with acute experimental pancreatitis. Bulletin of Experimental Biology and Medicine, 159: 32–34. DOI: 10.1007/s10517-015-2882-0.
Abdreshov, SN, Demchenko, GA & Yeshmukhanbet, AN et al. 2024, Morphofunctional alteration of mesenteric lymph nodes in the inflammation of the abdominal cavity. Biology, 13(3): 166. DOI: 10.3390/biology13030166.
Abdreshov, SN, Demchenko, GA, Kozhaniyazova, UN, Yessenova, MA, Yeshmukhanbet, AN et al. 2024, Lymph flow, ionic and biochemical indicators of lymph and blood during hypoxia. Brazilian Journal of Biology, 84: e284264. DOI: 10.1590/1519-6984.284264.
Abdreshov, SN, Demshenko, GA 2009, Shifts in the lymph flow and the lymph composition in toxic hepatitis and their correction by protective substances. Bulletin of Experimental Biology and Medicine, 148: 403–405. DOI: 10.1007/s10517-010-0723-8.
Abdreshov, SN, Ibraikhan, AT & Alayev, IKh 2018, The effect of toxicants on the membrane hydrolysis of the digestive tract in animals. News of the National Academy of Sciences RK, Series of Agricultural Sciences, (6): 24–31. DOI: 10.32014/2018.2224-526X.15.
Abdreshov, SN, Serik, BM, Mamataeva, AT, Utegalieva, PS, Zhaparkulova, NI 2021, The impact of lead salts on biochemical parameters in the lymph of animals. Reports of the National Academy of Sciences of the Republic of Kazakhstan, (1): 83–89. DOI: 10.32014/2021.2518-1483.12.
Attia, AMM, Fatma, AAI, Noha, AAE & Samir, WA 2014, Antioxidant effects of curcumin against cadmium chloride-induced oxidative stress in the blood of rats. Journal of Pharmacognosy and Phytotherapy, 6(3): 33–40. DOI: 10.5897/JPP2014.0316.
Balali-Mood, M, Naseri, K, Tahergorabi, Z, Khazdair, MR & Sadeghi, M 2021, Toxic mechanisms of five heavy metals: Mercury, lead, chromium, cadmium, and arsenic. Frontiers in Pharmacology, 12: 643972. DOI: 10.3389/fphar.2021.643972.
Baskurt, OK & Meiselman, HJ 2003, Blood rheology and hemodynamics. Seminars in Thrombosis and Hemostasis, 29(5): 435–450. DOI: 10.1055/s-2003-44551.
Borodin, YI 2005, Regional lymphatic drainage and lymphodetoxication. Morfologiia, 128(4): 25–28. PMID: 16400916.
Boujelben, M, Ghorbel, F, Vincent, C, Makni-Ayadi, F, Guermazi, F, Croute, F & El-Feki, A 2006, Lipid peroxidation and HSP72/73 expression in rat following cadmium chloride administration: Interactions of magnesium supplementation. Experimental and Toxicologic Pathology, 57(5–6): 437–443. DOI: 10.1016/j.etp.2006.02.012.
Bridenbaugh, EA, Nizamutdinova, IT, Jupiter, D et al. 2013, Lymphatic muscle cells in rat mesenteric lymphatic vessels of various ages. Lymphatic Research and Biology, 11(1): 35–42. DOI: 10.1089/lrb.2012.0025.
Carocci, A, Rovito, N, Sinicropi, MS & Genchi, G 2014, Mercury toxicity and neurodegenerative effects. Reviews of Environmental Contamination and Toxicology, 229: 1–18. DOI: 10.1007/978-3-319-03777-6_1.
Charkiewicz, AE, Omeljaniuk, WJ, Nowak, K, Garley, M & Nikliński, J 2023, Cadmium toxicity and health effects—A brief summary. Molecules, 28: 6620. DOI: 10.3390/molecules28186620.
Chen, CY, Zhang, SL, Liu, ZY, Tian, Y & Sun, Q 2015, Cadmium toxicity induces ER stress and apoptosis via impairing energy homeostasis in cardiomyocytes. Bioscience Reports, 35(3): e00214. DOI: 10.1042/BSR20140170.
Chen, XX, Xu, YM & Lau, ATY 2022, Metabolic effects of long-term cadmium exposure: An overview. Environmental Science and Pollution Research, 29(60): 89874–89888. DOI: 10.1007/s11356-022-23620-6.
Davidova, S, Milushev, V & Satchanska, G 2024, The mechanisms of cadmium toxicity in living organisms. Toxics, 12: 875. DOI: 10.3390/toxics12120875.
Fatullayeva, S, Tagiyev, D & Zeynalov, N 2021, A review on enterosorbents and their application in clinical practice: Removal of toxic metals. Colloid and Interface Science Communications, 45: 100545. DOI: 10.1016/j.colcom.2021.100545.
Franzoni, G, Ciccotelli, V, Masiello, L, De Ciucis, CG, Anfossi, AG, Vivaldi, B et al. 2022, Cadmium and wild boar: Environmental exposure and immunological impact on macrophages. Toxicology Reports, 9: 171–180. DOI: 10.1016/j.toxrep.2022.01.009.
Genchi, G, Sinicropi, MS, Lauria, G, Carocci, A & Catalano, A 2020, The effects of cadmium toxicity. International Journal of Environmental Research and Public Health, 17(11): 3782. DOI: 10.3390/ijerph17113782.
Gorchakova, O, Gorchakov, V, Kolmogorov, Yu, Nurmakhanova, B et al. 2021, Microelement profile and structure of regional lymph nodes during senile involution of lymphoid tissue. ArchivEuromedica, 11(1): 48–51. DOI: 10.35630/2199-885X/2021/11/1.9.
Haouem, S & El Hani, A 2013, Effect of cadmium on lipid peroxidation and on some antioxidants in the liver, kidneys and testes of rats given diet containing cadmium-polluted radish bulbs. Journal of Toxicologic Pathology, 26(4): 359–364. DOI: 10.1293/tox.2013-0025.
Helms, HC, Abbott, NJ, Burek, M, Cecchelli, R, Couraud, PO, Deli, MA et al. 2016, In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. Journal of Cerebral Blood Flow & Metabolism, 36(5): 862–890. DOI: 10.1177/0271678X16630991.
Hladky, SB & Barrand, MA 2016, Fluid and ion transfer across the blood-brain and blood-cerebrospinal fluid barriers: A comparative account of mechanisms and roles. Fluids and Barriers of the CNS, 13(1): 19. DOI: 10.1186/s12987-016-0040-3.
Iannitti, T, Capone, S, Gatti, A, Capitani, F, Cetta, F & Palmieri, B 2010, Intracellular heavy metal nanoparticle storage: Progressive accumulation within lymph nodes with transformation from chronic inflammation to malignancy. International Journal of Nanomedicine, 5: 955–960. DOI: 10.2147/IJN.S14363.
Järup, L 2003, Hazards of heavy metal contamination. British Medical Bulletin, 68(1): 167–182. DOI: 10.1093/bmb/ldg032.
Jung, K, Pergande, M, Graubaum, HJ, Fels, LM, Endl, U & Stolte, H 1993, Urinary proteins and enzymes as early indicators of renal dysfunction in chronic exposure to cadmium. Clinical Chemistry, 39(5): 757–765.
Leong, SP, Pissas, A, Scarato, M, Gallon, F, Pissas, MH, Amore, M et al. 2022, The lymphatic system and sentinel lymph nodes: Conduit for cancer metastasis. Clinical and Experimental Metastasis, 39(1): 139–157. DOI: 10.1007/s10585-021-10123-w.
Mezynska, M & Brzóska, MM 2018, Environmental exposure to cadmium—A risk for health of the general population in industrialized countries and preventive strategies. Environmental Science and Pollution Research, 25(4): 3211–3232. DOI: 10.1007/s11356-017-0827-z.
Mikhalovsky, S, Voytko, O, Demchenko, V & Demchenko, P 2021, Enterosorption in the treatment of heavy metal poisoning. Chemistry Journal of Moldova, 16(2): 9–27. DOI: 10.19261/cjm.2021.852.
Murisasco, A, Baz, M, Boobes, Y, Bertocchio, P et al. 1986, A continuous hemofiltration system using sorbents for hemofiltrate regeneration. Clinical Nephrology, 26: S53–S57.
Mussayeva, A, Kozhaniyazova, U, Koibasova, L, Demchenko, GA, Yessenova, M et al. 2025, Morphological changes in brain tissue during experimental hypoxia. OnLine Journal of Biological Sciences, 25(4): 1000–1007. DOI: 10.3844/ojbsci.2025.1000.1007.
Nadirova, S, Sinyavskiy, Yu, Abdreshov, S, Deripaskina, Y & Torgautov, A 2022, The effect of enriched yoghurt on the antioxidant activities of rats poisoned with cadmium salts. Nutrition and Food Science, 52(2): 320–333. DOI: 10.1108/NFS-03-2021-0100.
Rafati, RM, Rafati, RM, Kazemi, S & Moghadamnia, AA 2017, Cadmium toxicity and treatment: An update. Caspian Journal of Internal Medicine, 8(3): 135–145. DOI: 10.22088/cjim.8.3.135.
Sapargaliev, EM, Sapargalieva, LA, Rakhimov, KD & Baturina, GM 2001, Tagan adsorbent: A natural mineral in medicine. Ust-Kamenogorsk, 80 p.
Sapin, MR 2007, Lymphatic system and its significance in immune processes. Morfologiia, 131(1): 18–22. PMID: 17526257.
Satarug, S 2018, Dietary cadmium intake and its effects on kidneys. Toxics, 6(1): 15. DOI: 10.3390/toxics6010015.
Schaefer, HR, Dennis, S & Fitzpatrick, S 2020, Cadmium: Mitigation strategies to reduce dietary exposure. Journal of Food Science, 85: 260–267. DOI: 10.1111/1750-3841.14997.
Sinicropi, MS, Caruso, A, Capasso, A, Palladino, C, Panno, A & Saturnino, C 2010, Heavy metals: Toxicity and carcinogenicity. Pharmacologyonline, 2: 329–333.
Tungushbaeva, ZB, Pernebekova, RK, Joldasbayeva, NM, Sharipov, G, Sharipova, S, Yermentayeva, ZM, Kaketaeva, IZ & Kuanysh, S 2025, Effects of cadmium chloride on the ultrastructure of animal somatic cells (gums, kidneys, and liver). CJES, 24(1): 99–106. DOI: 10.22124/cjes.2026.9501. | ||
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آمار تعداد مشاهده مقاله: 9 تعداد دریافت فایل اصل مقاله: 6 |
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